Last update 01 Nov 2024

CD138 x CD3

Last update 01 Nov 2024

Basic Info

Related Targets

CD138CD3

Drugs associated with CD138 x CD3

STL001

Target

CD138 x CD3

Mechanism

CD138 inhibitors [+1]

Active Org.

Medical College of Soochow University

Originator Org.

Medical College of Soochow University

Active Indication

Multiple Myeloma

Inactive Indication-

Drug Highest PhasePreclinical

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

100 Clinical Results associated with CD138 x CD3

100 Translational Medicine associated with CD138 x CD3

0 Patents (Medical) associated with CD138 x CD3

374

Literatures (Medical) associated with CD138 x CD3

01 Dec 2024·Brain, Behavior, & Immunity - Health

Characterising how a single bout of exercise in people with myeloma affects clonal plasma cell and immune effector cell frequency in blood, and daratumumab efficacy in vitro

Article

Author: Murray, James ; Brown, Frankie F ; Oliver, Rebecca ; Turner, James E ; Collier-Bain, Harrison D. ; Collier-Bain, Harrison D ; Graby, John ; Moore, Sally ; Campbell, John P ; Eddy, Rachel ; Leach, Shoji ; Augustine, Daniel ; Crowe, Josephine ; Emery, Annabelle ; Causer, Adam J. ; Brown, Frankie F. ; Causer, Adam J ; Turner, James E. ; Campbell, John P.

Multiple myeloma is a haematological cancer characterised by the accumulation of clonal plasma cells in the bone marrow and is commonly treated with daratumumab, an anti-CD38 monoclonal antibody immunotherapy. Daratumumab often fails to induce stringent complete responses, due in part to resistance to antibody-dependent cellular cytotoxicity (ADCC) exerted by natural killer (NK)-cells and monocytes. Exercise bouts undertaken by healthy people induce lymphocytosis in blood, including to NK-cells and B-cells, but the effects of exercise are unknown in myeloma patients. In addition, whether exercise mobilises plasma cells has not been adequately investigated, and as such the potential impact of exercise on daratumumab treatment is unclear. In this exploratory pilot study, n = 16 smouldering multiple myeloma participants enrolled and n = 9 completed the study which comprised a bout of cycling 15% above anaerobic threshold for ∼30-min, with blood samples collected pre-, immediately post-, and 30-min post-exercise. Peripheral blood mononuclear cells were isolated from blood samples and incubated with the RPMI-8226 plasmacytoma cell line, with or without the presence of daratumumab to determine specific lysis using a calcein-release assay. Daratumumab-mediated cell lysis increased from 18.8% to 23.2% pre- to post-exercise, respectively (p < 0.001), owing to an increased frequency of CD3^-CD56⁺CD16⁺ NK-cells (+348%), HLA-DR⁺CD14^dimCD16⁺ monocytes (+125%), and HLA-DR⁺CD14⁺CD32⁺ monocytes (+41%) in blood (p < 0.01). However, overall, total plasma cells (CD38⁺CD138⁺) nor clonal plasma cells (CD38^brightCD138⁺CD45^-/dimCD19^- with light-chain restriction) increased in blood (p > 0.05). Notably, we observed a 305% increase in NK-cells expressing CD38, the daratumumab target antigen, which might render NK-cells more susceptible to daratumumab-mediated fratricide - whereby NK-cells initiate ADCC against daratumumab-bound NK-cells. In conclusion, exercise modestly improved the efficacy of daratumumab-mediated ADCC in vitro. However, plasma cells were largely unchanged, and NK-cells expressing CD38 - the daratumumab target antigen - increased in blood. Future research should consider the optimal timings of exercise during daratumumab treatment in myeloma to avert exacerbation of daratumumab-mediated NK-cell lysis.

01 Sep 2024·Journal of Clinical Pathology

Autopsy findings from patients diagnosed with COVID-19 demonstrate unique morphological patterns in bone marrow and lymph node

Article

Author: Edwards, Robert A ; Guccione, Jack P ; Kim, Annette S ; Fell, Geoffrey G ; Pinkus, Geraldine S ; AlJabban, Ali ; Pozdnyakova, Olga ; Evans, Mark G ; Padera, Robert F

AimsThe identification of haemophagocytosis in bone marrow (BM) is recurrently identified in patients with severe COVID-19. These initial COVID-19 autopsy studies have afforded valuable insight into the pathophysiology of this disease; however, only a limited number of case series have focused on lymphoid or haematopoietic tissues.MethodsBM and lymph node (LN) specimens were obtained from adult autopsies performed between 1 April 2020 and 1 June 2020, for which the decedent had tested positive for SARS-CoV-2. Tissue sections (H&E, CD3, CD20, CD21, CD138, CD163, MUM1, kappa/lambda light chains in situ hybridisation) were examined by two haematopathologists, who recorded morphological features in a blinded fashion. Haemophagocytic lymphohistiocytosis (HLH) was assessed based on HLH 2004 criteria.ResultsThe BM demonstrated a haemophagocytic pattern in 9 out of 25 patients (36%). The HLH pattern was associated with longer hospitalisation, BM plasmacytosis, LN follicular hyperplasia and lower aspartate aminotransferase (AST), as well as ferritin at demise. LN examination showed increased plasmacytoid cells in 20 of 25 patients (80%). This pattern was associated with a low absolute monocyte count at diagnosis, lower white cell count and lower absolute neutrophil count at demise, and lower ferritin and AST at demise.ConclusionsAutopsy results demonstrate distinct morphological patterns in BM, with or without haemophagocytic macrophages, and in LN, with or without increased plasmacytoid cells. Since only a minority of patients met diagnostic criteria for HLH, the observed BM haemophagocytic macrophages may be more indicative of an overall inflammatory state.

01 Sep 2024·International Journal of Periodontics & Restorative Dentistry

Stromal Cells Associated with Soft Tissue Augmentation by a Volume-Stable Collagen Matrix (VCMX) Are Predominated by Anti-inflammatory/Reparative Macrophages

Article

Author: Thoma, Daniel ; Vered, Marilena ; Maymon-Gil, Tal ; Thoma, Daniel S ; Thoma, Daniel S. ; Netanely, Erez ; Artzi, Zvi ; Gil, Tal Maymon ; Renert, Uri

This article defines immunophenotypes of stromal inflammatory and endothelial cells and fibroblasts 3 months after augmentation of the peri-implant soft tissue using a porcine cross-linked collagen matrix (VCMX). Peri-implant soft tissue samples were obtained from 12 patients at the lining mucosa (LM)-masticatory mucosa (MM) junction before (1) and 3 months after (2) augmentation. Immu- nohistochemical stains were performed to identify inflammatory cells (T [CD3] and B [CD20] lym- phocytes, plasma cells [CD138]), macrophages (CD68-proinflammatory, CD163-anti-inflammatory/ reparative), endothelial cells (CD31, CD34), and fibroblasts (CD90, TE-7). Differences in the mean positively stained cells pre- and postaugmentation were analyzed by Wilcoxon signed-rank test. CD31+ endothelial cells showed increased mean numbers in MM2 compared to MM1 (P = .025) and in LM2 compared to LM1 (P = .047). CD163+ anti-inflammatory macrophages showed higher mean numbers in MM2 than in MM1 (P = .021) and in LM2 than in LM1 (P = .012). All other cell phenotypes showed nonsignificant changes between pre- and postaugmentation. This molecular study provides novel insight on the frequency of stromal cell phenotypes in the wound healing process at 3 months postaugmentation with VCMX, with anti-inflammatory CD163+ macrophages being predominant. This should be further investigated to help find novel therapeutic approaches to modulate and promote the VCMX-related healing process.

Analysis

Perform a panoramic analysis of this field.

view full example data

Chat with Hiro

Get started for free today!

Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.

Start your data trial now!

Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.

Bio

Bio Sequences Search & Analysis

Chemical

Chemical Structures Search & Analysis