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Last update 23 Jan 2025

SERPINB3

Last update 23 Jan 2025

Basic Info

Synonyms

HsT1196, Protein T4-A, SCC

+ [8]

Introduction

May act as a papain-like cysteine protease inhibitor to modulate the host immune response against tumor cells. Also functions as an inhibitor of UV-induced apoptosis via suppression of the activity of c-Jun NH(2)-terminal kinase (JNK1).

Drugs associated with SERPINB3

CN115894695

Patent Mining

Target

SERPINB3

Mechanism-

Active Org.

Zhengzhou Immuno BIOTECH Co., Ltd.

Originator Org.

Zhengzhou Immuno BIOTECH Co., Ltd.

Active Indication

Neoplasms

Inactive Indication-

Drug Highest PhaseDiscovery

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

100 Clinical Results associated with SERPINB3

100 Translational Medicine associated with SERPINB3

0 Patents (Medical) associated with SERPINB3

1,528

Literatures (Medical) associated with SERPINB3

03 Jan 2025·Science Advances

A rare dominant allele DYSOC1 determines seed coat color and improves seed oil content in Brassica napus

Article

Author: Chao, Hongbo ; Fan, Shipeng ; Chen, Kang ; Xiong, Yiyi ; Yan, Shuxiang ; Ding, Yiran ; Zhang, Libin ; Li, Maoteng ; Xia, Yutian ; Jia, Haibo ; Cheng, Xin ; Zhang, Chunyu ; Li, Huaixin ; Wang, Xiaodong ; He, Jianjie ; Wu, Mingli ; Yin, Yongtai

Yellow seed coat color (SCC) is a valuable trait in Brassica napus , which is significantly correlated to high seed oil content (SOC) and low seed lignocellulose content (SLC). However, no dominant yellow SCC genes were identified in B. napus . In this study, a dominant yellow SCC B. napus N53-2 was verified, and then 58,981 eQTLs and 25 trans-eQTL hotspots were identified in a double haploid population derived from N53-2 and black SCC material Ken-C8. A rare dominant allele DYSOC1 ( dominant gene of yellow seed coat color and improved seed oil content 1 ) was subsequently cloned in a trans-eQTL hotspot that colocated with SCC, SOC, and SLC QTL hotspot on ChrA09 through QTL fine mapping and multi-omics analysis. Transgenic experiments revealed that the expression of DYSOC1 produced yellow SCC seeds with significantly increased SOC and decreased SLC. Our result provides a rare dominant yellow SCC allele in B. napus , which has excellent potential for yellow SCC and high SOC rapeseed breeding.

01 Jan 2025·Clinica Chimica Acta

Multi-center study on the application potential of Siaα-2,6Gal in early and differential diagnosis of lung cancer

Article

Author: Chen, Yongjian ; Wen, Qiuyuan ; Zhou, Feifei ; Shen, Yuhuan ; Cui, Wenhao ; Chen, Jierong ; Lu, Xiuwei ; Guan, Jinju ; Chen, Yuhan ; Yue, Si

OBJECTIVEThis study aimed to investigate the application potential of the abnormal glycan structure Siaα-2,6Gal in the early and differential diagnosis of lung cancer.METHODSClinical data and serum samples from 730 patients and 120 healthy individuals participating in clinical trials on Siaα-2,6Gal were collected at three medical centers between January 2022 and June 2023. The levels of Siaα-2,6Gal, carcinoembryonic antigen (CEA), cytokeratin 19 fragment antigen (CYFRA21-1), squamous cell carcinoma antigen (SCC), neuron-specific enolase (NSE), and pro-gastrin-releasing peptide (ProGRP) in serum were measured. The application potentials of these markers in the early and differential diagnosis, classification, and staging of lung cancer were explored.RESULTS(1) Serum Siaα-2,6Gal levels in the lung cancer group were 2,606 (1,970-3,458) U/mL, significantly higher than those in the benign lung disease, miscellaneous malignant tumor, miscellaneous benign disease, and healthy individual groups at 1,359 (950-1,528), 1,252 (903-1,532), 1,196 (850-1,490), and 1,210 (1,100-1,287) U/mL (P < 0.0001). (2) Serum Siaα-2,6Gal levels in the early-stage lung cancer (stages 0-II) group were 2,576 (1,929-3,338) U/mL, significantly higher than those in the benign pulmonary nodule group at 1,419 (1,105-1,820) U/mL (P < 0.0001). (3) Receiver operating characteristic curves showed that Siaα-2,6Gal had a high diagnostic efficiency for lung cancer (area under the curve (AUC) = 0.9217), significantly superior to CEA, CYFRA21-1, SCC, NSE, and ProGRP (AUCs of 0.6618, 0.6605, 0.5783, 0.5985, and 0.6381).CONCLUSIONSiaα-2,6Gal is a promising biomarker for lung cancer diagnosis and may offer superior differential diagnosis of early-stage lung cancer from benign pulmonary nodules compared to traditional tumor markers.

01 Jan 2025·Biosensors and Bioelectronics

Ultrasensitive detection of SCCA employing a graphene oxide integrated microfiber ring laser biosensor

Article

Author: Liu, Xiaokai ; Sang, Xinzhu ; Yuan, Jinhui ; Sun, Guoyong ; Yu, Chongxiu ; Wu, Qiang ; Yan, Binbin ; Rao, Lan ; Wang, Kuiru ; Xie, Ruen ; Chen, Yuping ; Chen, Shaobin ; Xin, Hu ; Li, Zefeng

Squamous cell carcinoma antigen (SCCA) is one of the most commonly detected cancer biomarkers for a variety of cancers. In this paper, a microfiber ring laser biosensor with a graphene oxide linking layer for SCCA detection was proposed and experimentally demonstrated. SCCA antibody immobilized on graphene oxide surface binds specifically to SCCA, and induces refractive index variation over the surface of the microfiber biosensor, which leads to a wavelength shift of the microfiber ring laser biosensor. The experimental results show that the proposed laser biosensor can detect SCCA with concentrations from 0.01 to 50 ng/mL, and the calculated detection limit can be as low as 1.3 pg/mL. Additionally, the label-free quantitative detection of SCCA using the proposed microfiber biosensor was verified experimentally according to the corresponding regression equation, and the results agree well with clinical examination detection. This constructed microfiber biosensor may have promising practical applications in analytical detection, medical diagnostics, etc.

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SERPINB3

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