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Last update 08 May 2025

SERPINB3

Last update 08 May 2025

Basic Info

Synonyms

HsT1196, Protein T4-A, SCC

+ [8]

Introduction

May act as a papain-like cysteine protease inhibitor to modulate the host immune response against tumor cells. Also functions as an inhibitor of UV-induced apoptosis via suppression of the activity of c-Jun NH(2)-terminal kinase (JNK1).

Drugs associated with SERPINB3

CN115894695

Patent Mining

Target

SERPINB3

Mechanism-

Active Org.

Zhengzhou Immuno BIOTECH Co., Ltd.

Originator Org.

Zhengzhou Immuno BIOTECH Co., Ltd.

Active Indication

Neoplasms

Inactive Indication-

Drug Highest PhaseDiscovery

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

100 Clinical Results associated with SERPINB3

100 Translational Medicine associated with SERPINB3

0 Patents (Medical) associated with SERPINB3

1,386

Literatures (Medical) associated with SERPINB3

10 Apr 2025·Microbiology Resource Announcements

Draft genomes of six methicillin-resistant Staphylococcus aureus in a Philippine tertiary hospital with insights on putative antimicrobial and phage resistance mechanisms

Article

Author: Carascal, Mark B. ; Papa, Donna May D. ; Tañedo, Ma. Mona Joy T. ; Gonzales, Jo-Eliz M. ; Destura, Raul V. ; Henson, Karl Evans R.

ABSTRACT The genomes of six methicillin-resistant Staphylococcus aureus (MRSA) revealed CC5(ST5)-SCC mec -IVc- spa -t105-PVL + ( n = 3), CC5(ST6)-SCC mec -IVc- spa -t10002 ( n = 1), CC5(ST5)-SCC mec -IVa- spa -t002 ( n = 1), and CC8(ST8)-SCC mec -IVa- spa -t008-PVL + ( n = 1) genotypes. All possessed multiple antibiotic resistance genes (putative mecA and blaZ, and dfrG for cotrimoxazole-resistant strains), intact staphylococcal prophages, and putative antiphage systems. The results could aid in MRSA infection management and control.

09 Apr 2025·mBio

Geographic divergence of methicillin-resistant Staphylococcus aureus ST5-SCC mec I in the aftermath of a major earthquake and tsunami: impact of a plasmid harboring heavy metal resistance genes

Article

Author: Reyes, Jinnethe ; Jara-Videla, Estefanía ; Martínez, Jose R. W. ; Ríos, Rafael ; Undurraga, Eduardo A. ; Quesille-Villalobos, Ana ; Hanson, Blake ; Rincon, Sandra ; Moustafa, Ahmed M. ; Carvajal, Lina P. ; Araos, Rafael ; Munita, Jose M. ; Arias, César A. ; García, Patricia ; Olivares-Pacheco, Jorge ; Alcalde-Rico, Manuel ; Planet, Paul J. ; Diaz, Lorena ; Riquelme-Neira, Roberto ; Rivas, Lina

ABSTRACT Methicillin-resistant Staphylococcus aureus (MRSA) is a major public health menace. The global spread of MRSA is characterized by successive waves of epidemic clones dominating specific geographical regions. The acquisition of genes encoding resistance to heavy metals (HMRGs) is thought to be a key feature in the geographic divergence of MRSA. However, the cause-effect relationship between the presence of HMRGs and the divergence of MRSA clones remains to be clarified. In this study, we assessed the role that HMRGs may have played in the evolutionary divergence of the MRSA ST5-SCC mec I lineage in Latin America. We conducted a genomic characterization of 113 MRSA clinical isolates from six Latin American healthcare centers, including 53 isolates collected from two cities in Chile (Santiago and Concepción). We found a plasmid (pSCL4752) harboring arsenic, cadmium, and mercury resistance genes in 65% ( n = 71) of the ST5-SCC mec I isolates. We also observed a geographic divergence associated with the presence of pSCL4752 in Chilean isolates, with a higher frequency in isolates from Concepción (88%) compared to Santiago (29%). Interestingly, a molecular clock analysis revealed that this divergence occurred in the aftermath of an 8.8 Mw earthquake and tsunami that struck the Concepción area in 2010. Moreover, our results demonstrate that the carriage of pSCL4752 can be beneficial or detrimental for ST5-SCC mec I isolates, depending on the environmental availability of these heavy metals. Our results suggest that the divergence of the ST5-SCC mec I MRSA lineage in Latin America could have been fostered by environmental disasters and influenced by the presence/absence of HMRGs harbored in a plasmid. IMPORTANCE Methicillin-resistant Staphylococcus aureus (MRSA) is a major cause of life-threatening infections worldwide and a growing public health concern. The rise of antibiotic-resistant bacteria, such as MRSA, is often linked to genetic adaptations that enhance their survival. Our research sheds light on how environmental changes, such as those triggered by a natural disaster, can influence the evolution and geographic spread of a highly resistant MRSA lineage in Latin America. We identified a plasmid carrying genes for resistance to arsenic, cadmium, and mercury, which was associated with the geographic divergence of the ST5-SCC mec I MRSA lineage, with striking differences in its prevalence between regions affected by a major earthquake and tsunami. By linking environmental events to pathogen evolution, our study highlights the role of ecological pressures in the spread of MRSA. These findings emphasize the need to integrate environmental monitoring into public health strategies to better understand the global challenge of antimicrobial resistance.

04 Apr 2025·Current Topics in Medicinal Chemistry

Advances in Cervical Cancer Diagnostics Based on Immunosensors: Innovative Approaches and Tumor Biomarkers

Article

Author: Dutra, Rosa Fireman ; Ferreira, Paula Angélica Burgos ; de Lima, Lucas Alves ; Souza, Anna Paula de Oliveira

Abstract:Immunosensors are promising analytical tools for screening and diagnosis of cervical cancer (CC) due to being practical, rapid and economical as compared with conventional methods. Choosing a sensible and specific tumor marker (TM) serving as target which is immobilized on sensor surface is a crucial step for a CC immunosensor. In addition, the transducer design involving optical, piezoelectric or electrochemical converting of antigen-antibody interaction in the analytical signals could be projected to achieve a maximal sensitivity, guarantying accuracy in the detection of CC. This review aims to describe more important TMs and transducers used for the development of immunosensors for CC. An overview of experimental articles published in the last decade designed to detect TM associated with CC, using optical, electrochemical and piezoelectric transductions mode are discussed. Although serological TM, such as SCCa, CEA and CA125 are still predominantly used, new biomarkers including the P16, MCM5 and PP1γ2 have been considered specific and reliable for CC diagnostic. Recently, new strategies such as multiplex assays and samples obtained directly from tumor tissue, as well self-sampling, have been proposed to overcome several limitations. Optical and electrochemical are the most popular transducers, and nanoparticles as electrochemical probes and sandwich assays have been the strategies for increasing the limit of detection and sensitivity of immunosensors for CC diagnostic.

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SERPINB3

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