Synonyms 次黄嘌呤磷酸核糖转移酶, HGPRT, HGPRTase + [5] |
Introduction Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5-phosphoribosyl group from 5-phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway. |
Target |
Mechanism HPRT1 inhibitors |
Active Org. |
Originator Org. |
Active Indication |
Inactive Indication |
Drug Highest PhaseApproved |
First Approval Ctry. / Loc. US |
First Approval Date11 Sep 1953 |
Target |
Mechanism HPRT1 inhibitors |
Active Org. |
Originator Org. |
Active Indication |
Inactive Indication- |
Drug Highest PhasePreclinical |
First Approval Ctry. / Loc.- |
First Approval Date20 Jan 1800 |
Target |
Mechanism HPRT1 agonists |
Active Org. |
Originator Org. |
Active Indication |
Inactive Indication- |
Drug Highest PhasePreclinical |
First Approval Ctry. / Loc.- |
First Approval Date20 Jan 1800 |
Start Date02 Apr 2025 |
Sponsor / Collaborator |
Start Date28 Feb 2025 |
Sponsor / Collaborator |
Start Date26 Jan 2025 |
Sponsor / Collaborator |