Synonyms 次黄嘌呤磷酸核糖转移酶, HGPRT, HGPRTase + [5] |
Introduction Converts guanine to guanosine monophosphate, and hypoxanthine to inosine monophosphate. Transfers the 5-phosphoribosyl group from 5-phosphoribosylpyrophosphate onto the purine. Plays a central role in the generation of purine nucleotides through the purine salvage pathway. |
Target |
Mechanism HPRT1 inhibitors |
Active Org. |
Originator Org. |
Active Indication |
Inactive Indication |
Drug Highest PhaseApproved |
First Approval Ctry. / Loc. US |
First Approval Date11 Sep 1953 |
Target |
Mechanism HPRT1 inhibitors |
Active Org.- |
Originator Org. |
Active Indication- |
Inactive Indication |
Drug Highest PhaseWithdrawn |
First Approval Ctry. / Loc. US |
First Approval Date19 Jul 1974 |
Target |
Mechanism DAP gene modulators [+2] |
Active Org.- |
Originator Org. |
Active Indication- |
Inactive Indication- |
Drug Highest PhasePending |
First Approval Ctry. / Loc.- |
First Approval Date20 Jan 1800 |
Start Date22 Apr 2024 |
Sponsor / Collaborator |
Start Date18 Apr 2024 |
Sponsor / Collaborator |
Start Date25 Jan 2024 |
Sponsor / Collaborator |