Request Demo

Last update 08 May 2025

TAAR5

Last update 08 May 2025

Basic Info

Synonyms

hTaar5, PNR, Putative neurotransmitter receptor

+ [5]

Introduction

Olfactory receptor specific for trimethylamine, a trace amine (PubMed:23393561). Also activated at lower level by dimethylethylamine (PubMed:23393561). Trimethylamine is a bacterial metabolite found in some animal odors, and to humans it is a repulsive odor associated with bad breath and spoiled food (PubMed:23393561). Trimethylamine-binding causes a conformation change that triggers signaling via G(s)-class of G alpha proteins (GNAL or GNAS) (PubMed:23393561).

Drugs associated with TAAR5

Salubrin-HF

Target

TAAR5

Mechanism

TAAR5 modulators

Active Org.

Pherin Pharmaceuticals, Inc.

Originator Org.

Pherin Pharmaceuticals, Inc.

Active Indication

Hot Flashes

Inactive Indication-

Drug Highest PhasePhase 2

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

HG-1149

Target

TAAR5

Mechanism

TAAR5 modulators

Active Org.-

Originator Org.

Human Genome Sciences, Inc.

Active Indication-

Inactive Indication

Nervous System Diseases

Drug Highest PhasePending

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

100 Clinical Results associated with TAAR5

100 Translational Medicine associated with TAAR5

0 Patents (Medical) associated with TAAR5

Literatures (Medical) associated with TAAR5

01 Jan 2025·Methods in Molecular Biology

Deorphanization of Olfactory Trace Amine-Associated Receptors

Article

Author: Li, Qian ; Hao, Yue ; Qian, Kang-Ying

Olfaction is the primary sense used by most animals to perceive the external world. The mouse olfactory system is comprised of several sensory structures, the largest of which is the main olfactory epithelium (MOE). Olfactory sensory neurons (OSNs) located within the MOE detect odors and pheromones using dedicated seven transmembrane, G protein-coupled receptors (GPCRs). Two families of GPCRs are expressed in the MOE and are conserved in humans and other vertebrates: odorant receptors (ORs) and trace amine-associated receptors (TAARs). TAARs are distantly related to biogenic amine receptors, such as dopamine and serotonin receptors. Several TAARs detect volatile amines, including ethological odors that evoke innate animal behavioral responses. Mouse TAAR4 recognizes the aversive predator odor 2-phenylethylamine, while mouse TAAR5 detects the attractive male mouse odor trimethylamine. In zebra fish, TAAR13c detects the foul death-associated odor cadaverine that mediates innate avoidance behavior. TAARs thus provide an excellent model subsystem to study odor valence. Identification of additional high-affinity ligands for TAARs will provide extra tools for such study. Therefore, this chapter focuses on the so-called SEAP (secreted alkaline phosphatase) assay that has been successfully applied for TAAR deorphanization in different species.

01 Sep 2024·Pharmacology Biochemistry and Behavior

Ligands of the trace amine-associated receptors (TAARs): A new class of anxiolytics

Review

Author: Alnefeesi, Yazen ; Sukhanov, Ilya ; Gainetdinov, Raul R

Most cases of anxiety are currently treated with either benzodiazepines or serotonin reuptake inhibitors. These drugs carry with them risks for a multitude of side effects, and patient compliance suffers for this reason. There is thus a need for novel anxiolytics, and among the most compelling prospects in this vein is the study of the TAARs. The anxiolytic potential of ulotaront, a full agonist at the human TAAR1, is currently being investigated in patients with generalized anxiety disorder. Irrespective of whether this compound succeeds in clinical trials, a growing body of preclinical literature underscores the relevance of modulating the TAARs in anxiety. Multiple behavioral paradigms show anxiolytic-like effects in rodents, possibly due to increased neurogenesis and plasticity, in addition to a panoply of interactions between the TAARs and other systems. Crucially, multiple lines of evidence suggest that the TAARs, particularly TAAR1, TAAR2, and TAAR5, are expressed in the extended amygdala and hippocampus. These regions are central in the actuation of anxiety, and are particularly susceptible to neurogenic and neuroplastic effects which the TAARs are now known to regulate. The TAARs also regulate the dopamine and serotonin systems, both of which are implicated in anxiety. Ligands of the TAARs may thus constitute a new class of anxiolytics.

23 Apr 2024·S.S. Korsakov Journal of Neurology and Psychiatry

Polymorphic variants in the cluster of genes encoding trace amine receptors and cognitive functioning in patients with schizophrenia spectrum disorders and healthy controls

Article

Author: Plakunova, V.V. ; Golimbet, V.E. ; Alfimova, M.V. ; Lezheiko, T.V.

Objective. To evaluate the association of polymorphisms in the TAAR1—9 gene cluster on chromosome 6 with cognitive functions in patients with schizophrenia spectrum disorders and healthy controls. Material and methods. Patients with schizophrenia spectrum disorders (n=216) and healthy people without a family history of mental disorders (n=240) completed a battery of cognitive tests, from which individual indices of cognitive functioning were derived. Associations of the cognitive index with 22 polymorphisms in the TAAR genes were assessed using ANCOVA controlling for sex, age, genetic structure of the sample, and polygenic risk scores of schizophrenia and intelligence. Results. An interaction effect between group and genotype on the cognitive index was found at the rs3813355 site in the TAAR5 gene (F=6.68; p=0.010; η2p=0.02). A post hoc analysis revealed genotype-related differences in the patient group. Homozygotes for the common A allele had a milder cognitive deficit than carriers of the minor G allele (t=2.75; p=0.032; Cohen’s d=0.38). The effect of genotype on cognitive index remained significant after the inclusion of disease duration and negative symptoms in the model (F=7.99; p=0.005; η2p=0.04). Of the individual cognitive indicators, associations with genotype were found for working memory and attention (F=8.25; p=0.005; η2p=0.05), cognitive flexibility (F=5.82; p=0.017; η2p=0.05) and verbal episodic memory (F=6.75; p=0.011; η2p=0.05). Conclusion. The results are consistent with the assumption of the role of the TAAR5 genetic polymorphism in the variability of cognitive deficits in patients with schizophrenia.

Analysis

Perform a panoramic analysis of this field.

view full example data

Hiro LS Researcher

The AI Search Engine Built to Accelerate Biopharma Decisions

Search across billion-scale life sciences data to uncover signals, validate evidence, and act with confidence.

Ask any biopharma research question→

Get started for free today!

Accelerate Strategic R&D decision making with Synapse, Patsnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.

Discover Synapse Data Servers

Synapse data is now integrated into the PatSnap LS Model Context Protocol (MCP) service. Customize your LLM agent now using our MCP server!

Bio

Bio Sequences Search & Analysis

Chemical

Chemical Structures Search & Analysis

TAAR5

Basic Info

Related

Analysis