Last update 21 Mar 2024

mTOR x NF-κB x FGFs x FLI1 x AP-1 x Na/K-ATPase x RPS6KB1

Serine/threonine-protein kinase mTOR x Nuclear factor NF-kappa-B complex x Fibroblast growth factors x Proto-oncogene protein c-fli-1 x Transcription factor AP1 x Sodium/potassium-transporting ATPase x Ribosomal protein S6 kinase beta-1

Basic Info

Related Targets
mTORNF-κBFGFs[+4]

Related

1
Drugs associated with mTOR x NF-κB x FGFs x FLI1 x AP-1 x Na/K-ATPase x RPS6KB1
Oleandrin
Target
AP-1 x FGFs x FLI1 x NF-κB x Na/K-ATPase x RPS6KB1 x mTOR
Mechanism
AP-1 inhibitors [+7]
Active Org.
U.S. Army Medical Research Institute for Infectious DiseasesU.S. Army Medical Research Institute for Infectious Diseases [+2]
Originator Org.
U.S. Army Medical Research Institute for Infectious DiseasesU.S. Army Medical Research Institute for Infectious Diseases
Active Indication
Pancreatic Cancer [+1]
Inactive Indication
Advanced cancer [+6]
Drug Highest PhasePhase 2
First Approval Ctry. / Loc.-
First Approval Date20 Jan 1800
3
Clinical Trials associated with mTOR x NF-κB x FGFs x FLI1 x AP-1 x Na/K-ATPase x RPS6KB1
NCT02329717 / Unknown statusPhase 2
A Phase II, Single-arm, Open-label, Bayesian Adaptive Efficacy and Safety Study of PBI-05204 in Patients With Stage IV Metastatic Pancreatic Adenocarcinoma
NCT01562301 / WithdrawnPhase 1IIT
A Phase I Study of the Combination of Carboplatin, Docetaxel, and Increasing Doses of Sublingual Anvirzel (Nerium Oleander) in Advance Non-Small Cell Lung Cancer
100 Clinical Results associated with mTOR x NF-κB x FGFs x FLI1 x AP-1 x Na/K-ATPase x RPS6KB1
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100 Translational Medicine associated with mTOR x NF-κB x FGFs x FLI1 x AP-1 x Na/K-ATPase x RPS6KB1
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0 Patents (Medical) associated with mTOR x NF-κB x FGFs x FLI1 x AP-1 x Na/K-ATPase x RPS6KB1
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