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Last update 08 May 2025

PTRH1

Last update 08 May 2025

Basic Info

Synonyms

C9orf115, peptidyl-tRNA hydrolase 1 homolog, Probable peptidyl-tRNA hydrolase

+ [3]

Introduction

Peptidyl-tRNA hydrolase that cleaves nascent chains-tRNAs that are not stably fixed in the P-site of 60S ribosome-nascent chain complexes (PubMed:30244831). Acts downstream of the ribosome-associated quality control (RQC) pathway to release non-ubiquitinated nascent chains from 60S and 80S ribosome-nascent chain complexes (PubMed:30244831). Does not act on ubiquitinated nascent chains, which are cleaved by ANKZF1 for degradation (PubMed:30244831).

Drugs associated with PTRH1

PTR1 inhibitors(University of Sassari)

Target

PTRH1

Mechanism

PTRH1 inhibitors

Active Org.-

Originator Org.

University of Sassari

Active Indication-

Inactive Indication

Leishmaniasis

Drug Highest PhasePending

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

100 Clinical Results associated with PTRH1

100 Translational Medicine associated with PTRH1

0 Patents (Medical) associated with PTRH1

Literatures (Medical) associated with PTRH1

11 Jul 2023·Journal of translational medicine

High glucose-upregulated PD-L1 expression through RAS signaling-driven downregulation of PTRH1 leads to suppression of T cell cytotoxic function in tumor environment.

Article

Author: Yin, Tao ; Tao, Yanyi ; Chen, Jiaoshun ; Gao, Chenggang ; Shen, Qiang ; Li, Hehe ; Bai, Jianwei ; Wu, Shihong ; Zhang, Haoxiang ; Wu, Heshui

BACKGROUNDNearly 80% of patients with pancreatic cancer suffer from glucose intolerance or diabetes. Pancreatic cancer complicated by diabetes has a more immunosuppressive tumor microenvironment (TME) and is associated with a worse prognosis. The relationship between glucose metabolism and programmed cell death-Ligand 1 (PD-L1) is close and complex. It is important to explore the regulation of high glucose on PD-L1 expression in pancreatic cancer and its effect on infiltrating immune effectors in the tumor microenvironment.METHODSDiabetic murine models (C57BL/6) were used to reveal different immune landscape in euglycemic and hyperglycemic pancreatic tumor microenvironment. Bioinformatics, WB, iRIP [Improved RNA Binding Protein (RBP) Immunoprecipitation]-seq were used to confirm the potential regulating role of peptidyl-tRNA hydrolase 1 homolog (PTRH1) on the stability of the PD-L1 mRNA. Postoperative specimens were used to identify the expression of PD-L1 and PTRH1 in pancreatic cancer. Co-culturing T cells with pancreatic cancer cells to explore the immunosuppressive effect of pancreatic tumor cells.RESULTSOur results revealed that a high dose of glucose enhanced the stability of the PD-L1 mRNA in pancreatic tumor cells by downregulating PTRH1 through RAS signaling pathway activation following epidermal growth factor receptor (EGFR) stimulation. PTRH1 overexpression significantly suppressed PD-L1 expression in pancreatic cells and improved the proportion and cytotoxic function of CD8⁺ T cells in the pancreatic TME of diabetic mice.CONCLUSIONSPTRH1, an RBP, plays a key role in the regulation of PD-L1 by high glucose and is closely related to anti-tumor immunity in the pancreatic TME.

01 Apr 2022·Journal of Cellular BiochemistryQ3 · BIOLOGY

Global interpretation of novel alternative splicing events in human congenital pulmonary airway malformations: A pilot study

Q3 · BIOLOGY

Article

Author: Zhao, Pu ; Ji, Xiang ; Li, Peng ; Miao, Chunlin ; Cheng, Jiwen ; Gao, Ya ; Yang, Weili ; Cao, Ping

AbstractLittle is known about differentially expressed genes (DEGs) and alternative splicing (AS) landscapes in congenital lung malformations (CLMs). We applied reference‐based assembly of sequencing reads from RNA sequencing (RNA‐seq) libraries to identify DEGs and AS landscapes in the lesions and normal lung tissue from the most common types of CLMs, including congenital pulmonary airway malformation‐Ⅰ (CPAM‐Ⅰ), CPAM‐Ⅱ, intralobar sequestration (ILS), and ILS with CPAM (ILS‐CPAM). We analyzed the expression profiles and related biological functions of AS events (ASEs). We further constructed a co‐expression regulatory network between RNA binding protein (RBP) genes and corresponding ASEs to explore the related pathways in the regulated network. Ten DEGs were identified in the four types of CLMs, including eight upregulated genes and two downregulated genes. Additionally, 16 differential ASEs were detected, including the genes MACF1, RFX2, and FBXL4. Gene ontology (GO) enrichment was mainly observed in embryonic visual malformation and apoptotic process, and the KEGG pathway mainly enriched in the PI3K/AKT signaling pathway. We also detected 13 differentially expressed RBPs among 1979 DEGs in CPAM‐I, in which ASEs in the MACF1 gene and RBP genes TLR8 and PTRH1 were closely associated. Moreover, we confirmed that the expression levels of PTRH1, NSUN7, and DZIP1L abundantly increased and the expression levels of TLR8, MEF2A, and NIPBL decreased in the CPAM‐I lung tissue compared with the controls. It is suggested that ASEs in different types of CLMs is prominently different from normal controls, and ASEs differences occurring in CPAM‐I malformation tissue are dramatically different from other types, which demonstrates the complex pathogenesis of CLMs and provides foundations for future studies to elucidate the mechanisms of developing CLMs.

01 Apr 2021·Advanced MaterialsQ1 · MATERIALS SCIENCE

A Tensile‐Strained Pt–Rh Single‐Atom Alloy Remarkably Boosts Ethanol Oxidation

Q1 · MATERIALS SCIENCE

Article

Author: He, Dongsheng ; Chen, Wen ; Luo, Shuiping ; Li, Lanxi ; Li, Mingrui ; Zhang, Long ; Wu, Qilong ; Quan, Zewei ; Wu, Xiaotong ; He, Chunyong ; Liao, Yujia ; Wu, Xiaoyu ; Yang, Qi ; Hensen, Emiel J. M.

AbstractThe rational design and control of electrocatalysts at single‐atomic sites could enable unprecedented atomic utilization and catalytic properties, yet it remains challenging in multimetallic alloys. Herein, the first example of isolated Rh atoms on ordered PtBi nanoplates (PtBi‐Rh1) by atomic galvanic replacement, and their subsequent transformation into a tensile‐strained Pt–Rh single‐atom alloy (PtBi@PtRh1) via electrochemical dealloying are presented. Benefiting from the Rh1‐tailored Pt (110) surface with tensile strain, the PtBi@PtRh1 nanoplates exhibit record‐high and all‐round superior electrocatalytic performance including activity, selectivity, stability, and anti‐poisoning ability toward ethanol oxidation in alkaline electrolytes. Density functional theory calculations reveal the synergism between effective Rh1 and tensile strain in boosting the adsorption of ethanol and key surface intermediates and the CC bond cleavage of the intermediates. The facile synthesis of the tensile‐strained single‐atom alloy provides a novel strategy to construct model nanostructures, accelerating the development of highly efficient electrocatalysts.

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PTRH1

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