Last update 01 Nov 2024

TRMT5

Last update 01 Nov 2024

Basic Info

Synonyms

KIAA1393, M1G-methyltransferase, TRM5

+ [5]

Introduction

Involved in mitochondrial tRNA methylation (PubMed:26189817). Specifically methylates the N1 position of guanosine-37 in various tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding.

100 Clinical Results associated with TRMT5

100 Translational Medicine associated with TRMT5

0 Patents (Medical) associated with TRMT5

Literatures (Medical) associated with TRMT5

01 Oct 2024·Small

Circulating B Cell‐Derived Small RNA Delivered by Extracellular Vesicles: A Dialogue Mechanism for Long‐Range Targeted Renal Mitochondrial Injury in Obesity

Article

Author: Han, Yi ; Wang, Cunchuan ; Yin, Lianghong ; Li, Hongyue ; Meng, Yu ; Hu, Bo ; Liu, Xiayun ; Zheng, Zirun ; Huang, Sibo ; Liu, Huanhuan ; Chen, Ruichang ; Xiao, Zhangzhang ; Liu, Jinfeng ; Ma, Ke ; Yang, Wah ; Li, Xiaqing ; Zhao, Qian

AbstractThe intricate processes that govern the interactions between peripatetic immune cells and distal renal injury in obesity are not fully understood. Employing transcriptomic analysis of circulating extracellular vesicles (EVs), a marked amplification of small RNA (miR‐3960) is discerned within CD3−CD19+ B cells. This RNA is found to be preferentially augmented in kidney tissues, contrasting with its subdued expression in other organs. By synthesizing dual‐luciferase reporter assay with co‐immunoprecipitation analysis, it is pinpointed that miR‐3960 specifically targets the nuclear gene TRMT5, a pivotal actor in the methylation of mitochondrial tRNA. This liaison instigates aberrations in the post‐transcriptional modifications of mitochondrial tRNA, engendering deficiencies within the electron respiratory chain, primarily attributable to the diminution of the mitochondrial bioenergetic compound (NDUFA7) complex I. Such perturbations lead to a compromised mitochondrial respiratory capacity in renal tubular cells, thereby exacerbating tubular injury. In contrast, EV blockade or miR‐3960 depletion markedly alleviates renal tubular injury in obesity. This investigation unveils a hitherto unexplored pathway by which obesity‐induced circulating immune cells remotely manipulate mitochondrial metabolism in target organs. The strategic targeting of obese EVs or infiltrative immune cells and their specifically secreted RNAs emerges as a promising therapeutic avenue to forestall obesity‐related renal afflictions.

01 Jul 2024·Translational Cancer Research

Novel mitochondrial-related gene signature predicts prognosis and immunological status in glioma

Article

Author: Chen, Guangliang ; Liu, Yongsheng ; Cai, Lize ; Yao, Lin ; Zhang, Kai ; Zhou, Youxin ; Wang, Hao

BackgroundMitochondria are the center of cellular metabolism. The relationship between mitochondria and diseases has also been studied for a long time. However, the prognostic role of mitochondrial-related genes (MRGs) in patients with glioma and their biological effects are still unclear. The aim of the study was to construct a mitochondria-related model to assess prognosis and potential biological effects like immune infiltration, gene pathway and mutation, and give some predictive chemotherapeutic agents.MethodsThe data of 675 patients from The Cancer Genome Atlas (TCGA) database were used to identify MRG signature and construct a prognostic model. After validating its robustness in Chinese Glioma Genome Atlas (CGGA), two risk groups derived from the prognostic model were then conducted with Gene Set Enrichment Analysis (GSEA), immune status, mutation status and chemotherapeutic agents prediction.ResultsThe prognostic model built from six gene signatures can successfully predict the prognosis and reflect clinicopathological characteristics. Patients in high-risk group displayed significantly worse overall survival (OS), immunosuppression effects, and mutation markers with worse prognosis. Twelve chemotherapeutic agents with strongly correlated sensitivity and risk scores were selected as potential agents.ConclusionsThe novel MRG signatures (TYMP, TSFM, MGME1, BOLA3, TRMT5, NDUFA9) can predict prognosis and immunological status in glioma.

01 Mar 2024·iScience

RNA modification-related genes illuminate prognostic signature and mechanism in esophageal squamous cell carcinoma

Article

Author: Ma, Jieyi ; Guo, Siyao ; Qiu, Hongshen ; Jiang, Xu ; Wang, Juan ; Liu, Lianlian ; Liu, Qianwen ; Zhang, Canfeng ; Wang, Zhaoyu ; Cheng, Maosheng ; Sun, Yucong ; Zheng, Siyi ; Wei, Wei ; Han, Hui ; Huang, Zixin ; Lin, Shuibin ; Zhang, Shuishen ; Zhang, Qiang ; Li, Zhenpeng

Emerging studies have demonstrated the link between RNA modifications and various cancers, while the predictive value and functional mechanisms of RNA modification-related genes (RMGs) in esophageal squamous cell carcinoma (ESCC) remain unclear. Here we established a prognostic signature for ESCC based on five RMGs. The analysis of ESCC clinical samples further verified the prognostic power of the prognostic signature. Moreover, we found that the knockdown of NSUN6 promotes ESCC progression in vitro and in vivo, whereas the overexpression of NSUN6 inhibits the malignant phenotype of ESCC cells. Mechanically, NSUN6 mediated tRNA m⁵C modifications selectively enhance the translation efficiency of CDH1 mRNA in a codon dependent manner. Rescue assays revealed that E-cadherin is an essential downstream target that mediates NSUN6's function in the regulation of ESCC progression. These findings offer additional insights into the link between ESCC and RMGs, as well as provide potential strategies for ESCC management and therapy.

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TRMT5

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