Request Demo

Last update 23 Jan 2025

Thymosin receptor

Last update 23 Jan 2025

Basic Info

Synonyms-

Introduction-

Drugs associated with Thymosin receptor

High serine thymosin alpha 1(Xi'an Disai Biological Pharmaceutical)

Target

Thymosin receptor

Mechanism

Thymosin receptor agonists

Active Org.-

Originator Org.

Xian Disai Biology Pharmaceutical Co. Ltd.

Active Indication-

Inactive Indication

Anemia [+1]

Drug Highest PhasePending

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

100 Clinical Results associated with Thymosin receptor

100 Translational Medicine associated with Thymosin receptor

0 Patents (Medical) associated with Thymosin receptor

Literatures (Medical) associated with Thymosin receptor

01 Feb 2000·Investigative ophthalmology & visual scienceQ2 · MEDICINE

Genes upregulated in the human trabecular meshwork in response to elevated intraocular pressure.

Q2 · MEDICINE

ArticleOA

Author: Gonzalez, P ; Epstein, D L ; Borrás, T

PURPOSETo identify genes upregulated in perfused, intact human trabecular meshwork (TM) in response to elevated intraocular pressure (IOP).METHODTwo pairs of anterior segments of normal human eyes from postmortem donors were placed in culture and perfused 24 hours at constant flow (3 microl/min). After reaching baseline, the flow of one eye from each pair was raised to obtain an incremental pressure (deltaP) of 50 mm Hg for 6 hours. The anterior segments were then quickly frozen in liquid nitrogen, and their TMs were dissected for RNA extraction. SMART cDNA libraries were generated from control and high-pressure human TM RNAs and hybridized to sets of identical high-density cDNA gene arrays. These arrays contained 18,376 human expressed sequence tags (ESTs), corresponding to both characterized and unknown genes. Differentially expressed genes were identified by different-intensity hybridization signals and confirmed by semi-quantitative polymerase chain reaction.RESULTSEleven genes were found to be consistently upregulated in the human TM by elevated IOP: interleukin-6, preprotachykinin-1, secretogranin-II, cathepsin-L, stromelysin-1, thymosin-beta4, alpha-tubulin, alphaB-crystallin, glyceraldehyde-3-phosphate dehydrogenase, metallothionein and Cu/Zn superoxide dismutase. The products of these genes are involved in vascular permeability, secretion, extracellular matrix remodeling, cytoskeleton reorganization, and reactive oxygen species scavenging.CONCLUSIONSElevated IOP induced specific upregulation of 11 physiologically relevant genes. On the basis of their known activities, the products of each of these genes might predict homeostatic mechanisms similar to those involved in the regulation of blood vessel permeability. We hypothesize that similar mechanisms might be involved in regulating flow through Schlemm's Canal endothelium.

01 Apr 1992·Journal of Biological ChemistryQ2 · BIOLOGY

Equine leukocyte elastase inhibitor. Primary structure and identification as a thymosin-binding protein.

Q2 · BIOLOGY

Article

Author: J J Enghild ; J Potempa ; J Travis ; A Dubin

The primary structure of an elastase inhibitor located in the cytoplasm of leukocytes obtained from the equine species has been determined. By sequence comparison, the protein was found to be a member of the serpin family with strong identity to plasminogen activator inhibitor-2. In contrast to other serpins this protein contained no carbohydrate and had a blocked amino terminus. Preliminary evidence indicates that the inhibitor has the additional feature of being a thymosin beta 4-binding protein, since this polypeptide was always located in purified preparations of the protein. This suggests a physiological role for cytoplasmic elastase inhibitors in the thymosin beta 4-regulated rearrangement of the cytoskeleton of leukocytes.

01 Jan 1989·Eksperimentalna meditsina i morfologiia

[Electron microscopic study of internalization stages of cellular receptors for insulin and alpha-1-thymosin].

Article

Author: Marinova, Ts ; Nenov, V

Initial stages of insulin-receptor interaction in two types of blood cells (erythrocytes and monocytes) as well as of thymosin-receptor interaction in thymic lymphocytes of rat were studied by electron microscope. Hormone-receptor complexes were marked by colloidal gold. There was general similarity at the initial stages of interaction of both peptide hormones and cellular, membrane receptors for them. Some characteristic and regular ultrastructural peculiarities were described in distribution, aggregation and early links of internalization of insulin-binding and thymosin-binding receptor sites, which could be taken into consideration analysing hormone-receptor interaction and of its defects at receptor and postreceptor level.

Analysis

Perform a panoramic analysis of this field.

view full example data

Chat with Hiro

Get started for free today!

Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.

Start your data trial now!

Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.

Bio

Bio Sequences Search & Analysis

Chemical

Chemical Structures Search & Analysis

Thymosin receptor

Basic Info

Related

Analysis