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Last update 08 May 2025

CHD4

Last update 08 May 2025

Basic Info

Synonyms

ATP-dependent helicase CHD4, CHD-4, CHD4

+ [5]

Introduction

ATP-dependent helicase that binds and distorts nucleosomal DNA (PubMed:28977666, PubMed:32543371). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:17626165, PubMed:28977666, PubMed:9804427). Localizes to acetylated damaged chromatin in a ZMYND8-dependent manner, to promote transcriptional repression and double-strand break repair by homologous recombination (PubMed:25593309). Involved in neurogenesis (By similarity).

Drugs associated with CHD4

Z36-MP5

Target

CHD4

Mechanism

CHD4 inhibitors

Active Org.

Zhejiang University

Originator Org.

Zhejiang University

Active Indication

Melanoma

Inactive Indication-

Drug Highest PhasePreclinical

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

ED2-AD101

Target

CHD4 x SMARCA5

Mechanism

CHD4 inhibitors [+1]

Active Org.-

Originator Org.

Novo Nordisk A/S

Active Indication-

Inactive Indication

Acute Myeloid Leukemia

Drug Highest PhasePending

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

100 Clinical Results associated with CHD4

100 Translational Medicine associated with CHD4

0 Patents (Medical) associated with CHD4

342

Literatures (Medical) associated with CHD4

01 Dec 2025·Functional & Integrative Genomics

DUBR non-coding RNA regulates gene expression by affecting AP-1 enhancer accessibility

Article

Author: Hall, Simone D ; Zhu, Jonathan ; Tran, Khoa ; McHugh, Colleen A ; Su, Tong

AbstractNon-coding RNAs (ncRNAs) are finely tuned cellular regulators important for human cell growth and cancer progression. DUBR (Dppa2 upstream binding RNA, also known as linc00883) is a nuclear ncRNA first discovered in mice for its role in regulating myoblast differentiation through interactions with chromatin and DNA methyltransferases. High expression levels of this ncRNA are predictive of poor patient outcome in colon adenocarcinoma, suggesting that DUBR may be involved in controlling cancer growth. To elucidate its function, we used RAP-MS and RNA immunoprecipitation techniques which revealed its interaction with epigenetic maintenance proteins in the human colon cancer cell line HCT116. Further, ATAC-seq and RNA-seq were used to address its function in regulating the epigenome and transcriptome of HCT116 cells. Here we report that DUBR is a regulator of human colon cancer cell line HCT116 survival. Additionally, we find that the ncRNA DUBR regulates AP-1 transcription factor binding site accessibility at enhancers of genes involved in differentiation and morphogenesis through interactions with epigenetic proteins such as NuRD complex members HDAC1 and CHD4.

01 Apr 2025·Immunology Letters

Seasonal patterns of myositis-specific and myositis-associated autoantibodies in Italy

Article

Author: Alessio, Maria Grazia ; Previtali, Giulia ; Palterer, Boaz ; Manfredi, Mariangela ; Parronchi, Paola ; Garrafa, Emirena ; Boni, Michela ; Bizzaro, Nicola ; Pesce, Giampaola ; Porcelli, Brunetta ; Tarricone, Nunzia Rita ; Infantino, Maria ; Sacchi, Maria Cristina ; Ghirardello, Anna ; Deleonardi, Gaia ; Carbone, Teresa ; Terzuoli, Lucia ; Semeraro, Roberto ; Annunziato, Francesco ; Mazzoni, Alessio ; Ghisellini, Sara ; Sorrentino, Maria Concetta ; Anzivino, Pierluigi ; Brusca, Ignazio

OBJECTIVEIdiopathic inflammatory myopathies (IIM) are a heterogeneous group of systemic autoimmune disorders affecting skeletal muscles but also other organs. There are different forms of IIM, each with peculiar clinical manifestations and prognosis. Accordingly, several autoantibodies have been described in IIM, with different prevalence in the different forms of the disease. The etiopathogenesis of IIM is still unclear, although environmental agents play certainly a role to trigger disease development in genetically predisposed individuals. Supporting this notion, some reports suggest that the incidence of IIM may be different throughout the year. In this work, we tested if the detection of autoantibodies typically observed in IIM has a seasonal pattern.METHODSWe collected serological data from line immunoassays (LIA) performed on 4277 patients with suspected IIM from January 2018 to December 2020 in ten Italian hospitals. Myositis-specific and myositis-associated autoantibodies were evaluated by line-immunoassay.RESULTSOur findings demonstrate that absolute numbers of anti-MDA5, anti-PM-Scl75, anti-Mi2b and anti-TIF1ɣ autoantibodies are more frequently detected in autumn-winter than in spring-summer. However, only anti-PM-Scl75 and anti-MDA5 display a similar pattern when analyzing frequencies of positive tests (for anti-PM-Scl75 100 positive tests and 2107 negative tests from September to February; 55 positive tests and 1903 negative tests from March to August, p = 0.003; for anti-MDA5 34 positive tests and 1983 negative tests from September to February; 17 positive tests and 1760 negative tests from March to August, p = 0.051).CONCLUSIONSThese findings suggests that triggering agents promoting the development of these autoantibodies have a specific seasonal pattern.

01 Apr 2025·International Journal of Surgical Pathology

High-Grade Appendiceal Mucinous Neoplasm Mimicking Appendiceal Tubulovillous Adenoma: A Case Report and Literature Review

Review

Author: Zhang, Shuhong ; Liu, Weihua ; Chen, Guangyong ; Shao, Huilin

High-grade appendiceal mucinous neoplasm (HAMN) has been separated from appendiceal adenocarcinoma recently as an independent entity and categorized into appendiceal mucinous neoplasms. These neoplasms demonstrate distinct histological characteristics, including architectures and appendiceal mural changes similar to low-grade appendiceal mucinous neoplasm but with high-grade cytology, and no infiltrative invasion. Overt mucinous feature are not evident in some cases as the high-grade neoplastic epithelium may show intracytoplasmic mucin reduction. Occasionally, the neoplastic epithelial cells show florid proliferation and tubulovillous configuration and may be misdiagnosed as appendiceal tubulovillous adenoma. We report the case of a 67-year-old woman with appendicular dilatation and luminal mucin. She underwent an ileocecoectomy. The appendiceal lesion was found histologically to be a HAMN, which closely resembled appendiceal tubulovillous adenoma. The tumor cells demonstrated wild-type p53 expression and mismatch repair proficiency by immunochemistry. Molecular testing showed 1 KRAS mutation, 2 PIK3CA mutations, and 1 BRCA2 , EP300 , TGFBR2 , CHD4 , CREBBP , FANCC , PKHD1 mutation each in the tumor. The patient was followed up for 1 year with no evidence of disease.

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