Last update 08 May 2025

L3MBTL3

Basic Info

Synonyms
H-l(3)mbt-like protein 3, KIAA1798, l(3)mbt-like 3 (Drosophila)
+ [8]
Introduction
Is a negative regulator of Notch target genes expression, required for RBPJ-mediated transcriptional repression (PubMed:29030483). It recruits KDM1A to Notch-responsive elements and promotes KDM1A-mediated H3K4me demethylation (PubMed:29030483). Involved in the regulation of ubiquitin-dependent degradation of a set of methylated non-histone proteins, including SOX2, DNMT1 and E2F1. It acts as an adapter recruiting the CRL4-DCAF5 E3 ubiquitin ligase complex to methylated target proteins (PubMed:29691401, PubMed:30442713). Required for normal maturation of myeloid progenitor cells (By similarity).

Related

2
Drugs associated with L3MBTL3
UNC1679
Target
L3MBTL3
Mechanism
L3MBTL3 inhibitors
Active Org.-
Originator Org.
The University of North Carolina at Chapel HillThe University of North Carolina at Chapel Hill
Active Indication-
Inactive Indication-
Drug Highest PhasePending
First Approval Ctry. / Loc.-
First Approval Date20 Jan 1800
UNC1215
Target
L3MBTL3
Mechanism
L3MBTL3 inhibitors
Active Org.-
Originator Org.
The University of North Carolina at Chapel HillThe University of North Carolina at Chapel Hill
Active Indication-
Inactive Indication
Neoplasms
Drug Highest PhasePending
First Approval Ctry. / Loc.-
First Approval Date20 Jan 1800
100 Clinical Results associated with L3MBTL3
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100 Translational Medicine associated with L3MBTL3
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0 Patents (Medical) associated with L3MBTL3
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49
Literatures (Medical) associated with L3MBTL3
20 Mar 2025Nucleic Acids Research
Cooperation of a polymerizing SAM domain and an intrinsically disordered region enables full SAMD1 function on chromatin
01 Jan 2025Journal of Molecular Modeling
Investigation of a novel Schiff base Catena-((μ6-(E)-2-((4-methoxy-2-oxidobenzylidene)ammonio)ethane-1-sulfonato potassium as a potential antibacterial agent
01 Feb 2023Heliyon
L3MBTL3 is induced by HIF-1α and fine tunes the HIF-1α degradation under hypoxia in vitro

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