Synonyms [3-methyl-2-oxobutanoate dehydrogenase [lipoamide]] kinase, mitochondrial, BCKD-kinase, BCKDHKIN + [3] |
Introduction Catalyzes the phosphorylation and inactivation of the branched-chain alpha-ketoacid dehydrogenase complex, the key regulatory enzyme of the valine, leucine and isoleucine catabolic pathways. Key enzyme that regulate the activity state of the BCKD complex. |
Target |
Mechanism BCKDK antagonists |
Active Org. |
Originator Org. |
Active Indication |
Inactive Indication- |
Drug Highest PhasePhase 1 |
First Approval Ctry. / Loc.- |
First Approval Date20 Jan 1800 |
Target |
Mechanism BCKDK antagonists |
Active Org. |
Originator Org. |
Active Indication |
Inactive Indication- |
Drug Highest PhasePreclinical |
First Approval Ctry. / Loc.- |
First Approval Date20 Jan 1800 |
Start Date05 Apr 2023 |
Sponsor / Collaborator |
Start Date17 Oct 2022 |
Sponsor / Collaborator |