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Last update 08 May 2025

NPBWR1

Last update 08 May 2025

Basic Info

Synonyms

G protein-coupled receptor 7, G-protein coupled receptor 7, GPR7

+ [4]

Introduction

Interacts specifically with a number of opioid ligands. Receptor for neuropeptides B and W, which may be involved in neuroendocrine system regulation, food intake and the organization of other signals. Has a higher affinity for neuropeptide B.

Drugs associated with NPBWR1

ML181

Target

NPBWR1

Mechanism

NPBWR1 antagonists

Active Org.

The Scripps Research Institute

Originator Org.

The Scripps Research Institute

Active Indication

Chronic Pain

Inactive Indication-

Drug Highest PhasePreclinical

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

ML250

Target

NPBWR1

Mechanism

NPBWR1 antagonists

Active Org.-

Originator Org.

The Scripps Research Institute

Active Indication-

Inactive Indication

Chronic Pain

Drug Highest PhasePending

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

100 Clinical Results associated with NPBWR1

100 Translational Medicine associated with NPBWR1

0 Patents (Medical) associated with NPBWR1

Literatures (Medical) associated with NPBWR1

01 Jun 2025·Biochemistry and Biophysics Reports

Characterization of lncRNA-protein interactions associated with Prostate cancer and Androgen receptors by molecular docking simulations

Article

Author: Ansari, Abdul S ; Lohiya, Nirmal K ; Suravajhala, Prashanth ; Kour, Bhumandeep ; Suravajhala, Renuka ; Vuree, Sugunakar ; Khilwani, Barkha ; Shukla, Nidhi

Long non-coding RNA (lncRNAs) are known to be implicated in pathogenesis of a broad spectrum of malignancies. These are found to have a significant role as signal transduction mediators in cancer signaling pathways. Prostate Cancer (PCa) is emerging with increasing cases worldwide even as advanced approaches in clinical diagnosis and treatment of PCa are still challenging to address. To enhance patient stratification, there is an indefatigable need to understand risk that can allow new approaches of treatment based on prognosis. While PCa is known to have mediated androgen receptor (AR) stimulation, the latter plays a critical role in regulating transcription of genes via nuclear translocation which in turn leads to response to androgens. LncRNAs have been implicated in developing clinical diagnostic and prognostic biomarkers in a broad spectrum of cancers. In our present study, 12 lncRNAs identified from clinical samples from our erstwhile PCa patients were docked with PCa and AR targeted 36 proteins. We identified three lncRNAs, viz. SCARNA10, NPBWR1, ANKRD20A9P are common between the targeted proteins and discern that SCARNA10 lncRNA could serve as a prognostic signature for PCa and AR biogenesis. We also sought to check the coding potential of interfacial residues associated with lncRNA docking sites.

01 May 2025·Molecular Psychiatry

Npbwr1 signaling mediates fast antidepressant action

Article

Author: Hübner, Christian A ; Hoffmann, Steve ; Stein, Gregor ; Manzolillo, Annamaria ; Brancato, Anna ; Riege, Konstantin ; Turecki, Gustavo ; Aly, Janine S ; Engmann, Olivia ; Lange, Lisa

AbstractChronic stress is a major risk factor for depression, a leading cause of disability and suicide. Because current antidepressants work slowly, have common side effects, and are only effective in a minority of patients, there is an unmet need to identify the underlying molecular mechanisms. Here, we identify the receptor for neuropeptides B and W, Npbwr1, as a key regulator of depressive-like symptoms. Npbwr1 is increased in the nucleus accumbens of chronically stressed mice and postmortem in patients diagnosed with depression. Using viral-mediated gene transfer, we demonstrate a causal link between Npbwr1, dendritic spine morphology, the biomarker Bdnf, and depressive-like behaviors. Importantly, microinjection of the synthetic antagonist of Npbwr1, CYM50769, rapidly ameliorates depressive-like behavioral symptoms and alters Bdnf levels. CYM50769 is selective, well tolerated, and shows effects up to 7 days after administration of a single dose. In summary, these findings advance our understanding of mood and chronic stress and warrant further investigation of CYM50769 as a potential fast-acting antidepressant.

17 Jan 2025·Science Advances

Central amygdala NPBWR1 neurons facilitate social novelty seeking and new social interactions

Article

Author: Sakurai, Takeshi ; Sakimura, Kenji ; Toda, Koji ; Soya, Shingo ; Saito, Yuki C. ; Abe, Manabu ; Sakurai, Katsuyasu ; Cherasse, Yoan

The formation of new social interactions is vital for social animals, but the underlying neural mechanisms remain poorly understood. We identified CeA Npbwr1 neurons, a population in central amygdala expressing neuropeptide B/W receptor-1 (NPBWR1), that play a critical role in these interactions. CeA Npbwr1 neurons were activated during encounters with unfamiliar, but not with familiar, mice. Manipulations of CeA Npbwr1 neurons showed that their excitation is essential for maintaining physical interactions with novel conspecifics. Activation of CeA Npbwr1 neurons alleviated social deficits induced by chronic social defeat stress, suggesting therapeutic potential. Conversely, overexpression of human NPBWR1 in CeA Npbwr1 neurons reduced activity of these neurons and impaired social interactions with unfamiliar mice. This effect was absent in a polymorphic variant of the human NPBWR1 gene (404A>T). These findings highlight how CeA Npbwr1 neurons promote social novelty seeking and reveal a complex interplay between NPBWR1 genetic variations and social behavior.

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NPBWR1

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