NS3/NS4A x NS5B polymerase x NS5A x HIV-1 pol

在健康的中国成年受试者中评价ABT-450/利托那韦/ABT-267和ABT-333于非空腹条件下多剂量口服联合给药的药代动力学和安全性。

There is compelling data supporting the pursuit of research into the effects of HCV antivirals on metabolic homeostasis. As a further rationale and justification, the experience with HIV antiretrovirals has clearly demonstrated that antiviral medications can produce profound changes in glucose metabolism, lipid profile and other measures of metabolic homeostasis. This establishes biological plausibility for this focus of research in HCV.
The new knowledge created from this research will:
Provide new information on the metabolic effects of the Abbvie 3D HCV antiviral regimen.
Provide insight as to whether there are metabolic advantages with RBV-free compared to RBV-containing HCV regimens. This is particularly relevant given the current uncertainty regarding the need for RBV in IFN-free, oral DAA regimens.
Provide insight into the impact of cirrhosis on metabolic milieu before, during and after HCV antiviral therapy