Last update 01 Nov 2024

COMMD4

Last update 01 Nov 2024

Basic Info

Synonyms

COMM domain containing 4, COMM domain-containing protein 4, COMMD4

+ [1]

Introduction

May modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes (PubMed:21778237). Down-regulates activation of NF-kappa-B.

Drugs associated with COMMD4

COMMD4 Inhibitor(Queensland University of Technology)

Target

COMMD4

Mechanism

COMMD4 inhibitors

Active Org.

Queensland University of Technology

Originator Org.

Queensland University of Technology

Active Indication

Lung Cancer

Inactive Indication-

Drug Highest PhasePreclinical

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

HG-1260

Target

COMMD4

Mechanism

COMMD4 modulators

Active Org.-

Originator Org.

Human Genome Sciences, Inc.

Active Indication-

Inactive Indication

Neoplasms

Drug Highest PhasePending

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

100 Clinical Results associated with COMMD4

100 Translational Medicine associated with COMMD4

0 Patents (Medical) associated with COMMD4

Literatures (Medical) associated with COMMD4

01 Jun 2024·Fish & Shellfish Immunology

Identification, diversity, and evolution analysis of Commd gene family in Haliotis discus hannai and immune response to biotic and abiotic stresses

Article

Author: Zhang, Tao ; Chen, Xin ; Wei, Huina ; Zhang, Wenxin ; Wang, Yilei ; Cai, Mingyi ; Chen, Yuping ; Zhang, Ziping ; Fan, Chao ; Huang, Jianpeng

The Commd (Copper Metabolism gene MURR1 Domain) family genes play crucial roles in various biological processes, including copper and sodium transport regulation, NF-κB activity, and cell cycle progression. Their function in Haliotis discus hannai, however, remains unclear. This study focused on identifying and analyzing the Commd genes in H. discus hannai, including their gene structure, phylogenetic relationships, expression profiles, sequence diversity, and alternative splicing. The results revealed significant homology between H. discus hannai's Commd genes and those of other mollusks. Both transcriptome quantitative analysis and qRT-PCR demonstrated the responsiveness of these genes to heat stress and Vibrio parahaemolyticus infection. Notably, alternative splicing analysis revealed that COMMD2, COMMD4, COMMD5, and COMMD7 produce multiple alternative splice variants. Furthermore, sequence diversity analysis uncovered numerous missense mutations, specifically 9 in COMMD5 and 14 in COMMD10. These findings contribute to expanding knowledge on the function and evolution of the Commd gene family and underscore the potential role of COMMD in the innate immune response of H. discus hannai. This research, therefore, offers a novel perspective on the molecular mechanisms underpinning the involvement of Commd genes in innate immunity, paving the way for further explorations in this field.

07 Dec 2023·British Journal of Cancer

Targeting the COMMD4–H2B protein complex in lung cancer

Article

Author: Fisher, Mark ; Gandhi, Neha S ; O'Byrne, Kenneth J ; Tang, Ming ; Burgess, Joshua T ; Boucher, Didier ; Bolderson, Emma ; Suraweera, Amila ; Richard, Derek J

AbstractBackgroundLung cancer is the biggest cause of cancer-related deaths worldwide. Non-small cell lung cancer (NSCLC) accounts for 85–90% of all lung cancers. Identification of novel therapeutic targets are required as drug resistance impairs chemotherapy effectiveness. COMMD4 is a potential NSCLC therapeutic target. The aims of this study were to investigate the COMMD4-H2B binding pose and develop a short H2B peptide that disrupts the COMMD4-H2B interaction and mimics COMMD4 siRNA depletion.MethodsMolecular modelling, in vitro binding and site-directed mutagenesis were used to identify the COMMD4-H2B binding pose and develop a H2B peptide to inhibit the COMMD4-H2B interaction. Cell viability, DNA repair and mitotic catastrophe assays were performed to determine whether this peptide can specially kill NSCLC cells.ResultsBased on the COMMD4-H2B binding pose, we have identified a H2B peptide that inhibits COMMD4-H2B by directly binding to COMMD4 on its H2B binding binding site, both in vitro and in vivo. Treatment of NSCLC cell lines with this peptide resulted in increased sensitivity to ionising radiation, increased DNA double-strand breaks and induction of mitotic catastrophe in NSCLC cell lines.ConclusionsOur data shows that COMMD4-H2B represents a novel potential NSCLC therapeutic target.

27 Apr 2021·British Journal of Cancer

Correction: Defining COMMD4 as an anti-cancer therapeutic target and prognostic factor in non-small cell lung cancer

Author: Duff, Alex ; O'Byrne, Kenneth J ; Beard, Sam ; Richard, Derek J ; Duijf, Pascal H G ; Suraweera, Amila ; Jekimovs, Christian ; McTaggart, Matthew ; Adams, Mark N ; Liu, Cheng

A Correction to this paper has been published: https://doi.org/10.1038/s41416-020-01242-4.

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