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Last update 08 May 2025

CCR10

Last update 08 May 2025

Basic Info

Synonyms

C-C chemokine receptor type 10, C-C CKR-10, C-C motif chemokine receptor 10

+ [7]

Introduction

Receptor for chemokines SCYA27 and SCYA28. Subsequently transduces a signal by increasing the intracellular calcium ions level and stimulates chemotaxis in a pre-B cell line.

Drugs associated with CCR10

CCR10 antagonists(Boehringer Ingelheim Corp)

Target

CCR10

Mechanism

CCR10 antagonists

Active Org.

Boehringer Ingelheim Corp.

Originator Org.

Boehringer Ingelheim Corp.

Active Indication

Inflammation

Inactive Indication-

Drug Highest PhaseDiscovery

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

CCR10 antagonist(Polyphor)

Target

CCR10

Mechanism

CCR10 antagonists

Active Org.-

Originator Org.

Spexis Ltd.

Active Indication-

Inactive Indication

Asthma [+1]

Drug Highest PhasePending

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

100 Clinical Results associated with CCR10

100 Translational Medicine associated with CCR10

0 Patents (Medical) associated with CCR10

436

Literatures (Medical) associated with CCR10

01 Mar 2025·Journal of Allergy and Clinical Immunology

Single-cell RNA sequencing of chronic idiopathic erythroderma defines disease-specific markers

Article

Author: Chennareddy, Sumanth ; Meledathu, Shannon ; Jonak, Constanze ; Griss, Johannes ; Bauer, Wolfgang M ; Naidu, Malini P ; Brunner, Patrick M ; Szmolyan, Lisa ; Weninger, Wolfgang ; Alkon, Natalia ; Rindler, Katharina ; Ruggiero, John R

BACKGROUNDChronic erythroderma is a potentially life-threatening condition that can be caused by various diseases, but approximately 30% of cases remain idiopathic, often with insufficient treatment options.OBJECTIVEWe sought to establish a molecular disease map of chronic idiopathic erythroderma (CIE).METHODSWe performed single-cell RNA sequencing combined with T-cell receptor sequencing of blood and skin from 5 patients with CIE and compared results with 8 cases of erythrodermic cutaneous T-cell lymphoma (eCTCL), 15 cases of moderate to severe atopic dermatitis, 10 cases of psoriasis, and 20 healthy control individuals.RESULTSIn eCTCL, we found strong expansion of CD4⁺ malignant clones with a CCR7⁺SELL⁺ central memory phenotype. In contrast, CIE exhibited a pattern of low-level, but consistent, expansion of CD8A⁺KLRK1⁺ T-cell clones, both in blood and in skin. KLRK1 was also expressed by CCR10⁺FUT7⁺ skin-homing CIE blood T cells that had increased proliferation rates and were absent in all other conditions. While patients with CIE and eCTCL lacked the strong type 2 or type 17 immune skewing typically found in atopic dermatitis or psoriasis, respectively, they were characterized by upregulation of MHC II genes (HLA-DRB1, HLA-DRA, and CD74) in keratinocytes and fibroblasts, most likely in an IFN-γ-dependent fashion. Overall, we found the strongest upregulation of type 1 immune mediators in CIE samples, both in the expanded CD8A⁺ clones and in the tissue microenvironment.CONCLUSIONSDespite the notion that CIE might be a mere bundle of various yet uncharacterized disease processes, we found specific pathogenic signatures in these patients, which were different from other forms of erythroderma. These data might help to improve our pathogenic understanding of the blood and skin compartments of CIE, aiding in discovery of future treatment targets.

01 Jan 2025·Journal of Dairy Science

Fatty acids promote migration of CD4+ T cells through calcium release-activated calcium modulator ORAI1 sensitive glycolysis in dairy cows

Article

Author: Wen, Jianan ; Usman, Muhammad ; Loor, Juan J ; Xu, Chuang ; Li, Ming ; Wang, Jingjing ; Wang, Guihua ; Loor, Juan J. ; Lv, Xinquan ; Mauck, John ; Ji, Ziwei ; Zhang, Bingbing ; Yang, Wei ; Ma, Jinzhu

Nutritional and metabolic state in dairy cows are important determinants of the immune response. During the periparturient period, a state of negative energy balance in the cow increases plasma concentrations of fatty acids (FA), which are associated with inflammation. Among immune cells, CD4⁺ T are able to function under high-FA conditions, but the underlying mechanisms regulating these events remain unclear. The objective of this study was to clarify the functional mechanisms of CD4⁺ T cells under high-FA conditions. The effects of glycolysis and calcium release-activated calcium modulator 1 (ORAI1) on migration of CD4⁺ T cells exposed to high FA were investigated in vivo and in vitro. The CD4⁺ T cells were isolated from peripheral blood of healthy (n = 9) and high-FA (n = 9) Holstein cows (average 2.5 ± 0.2 lactations [SE], 12.3 ± 0.8 DIM). In the first experiment, real-time quantitative PCR was used to assess chemokine receptors in isolated CD4⁺ T cells and migration capacity. The relative mRNA measurements results revealed downregulation of CCR1 and CXCR2, and upregulation of CCR2, CCR4, CCR5, CCR7, CCR8, CCR10, CXCR1, CXCR3, CXCR4, and CX3CR1. Among them, the expression of CXCR4 was relatively high. Therefore, CXCL12, a ligand chemokine of CXCR4, was an inducer of CD4⁺ T cell migration. The CD4⁺ T cells were inoculated in the upper chamber and CXCL12 (100 ng/mL, Peprotech) in RPMI1640 was added to the lower chamber and transmigrated for 3 h at 37°C and 5% CO₂. The cell migration assay revealed that the migration capacity of CD4⁺ T cells from high-FA cows was greater. Real-time-qPCR indicated greater abundance of the glycolysis-related targets HIF1A, HK2, PKM2, Glut1, GAPDH, and LDHA and Western blotting indicated greater abundance of the glycolysis-related targets HIF1A, HK2, PKM2, Glut1, GAPDH, and LDHA in CD4⁺ T cells of high-FA cows. To characterize specific mechanisms of CD4⁺ T cell migration in vitro, cells from the spleens of 3 newborn (1 d old, 40-50 kg) healthy female Holstein calves were isolated after euthanasia. Inhibition of glycolysis attenuated the migration ability of cells, but had no effect on the protein and mRNA abundance of store-operated Ca²⁺ entry (SOCE)-associated calcium release-activated calcium modulator 1 (ORAI1) and stromal interaction molecule 1 (STIM1). In contrast, ORAI1 was upregulated in CD4⁺ T cells of cows exposed to high FA. To explore the potential mechanisms whereby an active glycolytic metabolism affects CD4⁺ T cells under high-FA conditions, we knocked down ORAI1 using small interfering RNA (siORAI1). Isolated CD4⁺ T cells from high-FA cows with the siORAI1 had an attenuated glycolytic metabolism and migration capacity. Taken together, these data suggested that calcium ions in CD4⁺ T cells from cows with high FA regulate glycolytic metabolism and influence cell migration at least in part by modulating ORAI1. Thus, these studies identified a novel mechanism of Ca²⁺ regulation of CD4⁺ T cell glycolytic metabolism affecting their migration through the SOCE pathway.

01 Dec 2024·Indian Journal of Otolaryngology and Head & Neck Surgery

An Increase in the Chemokine Mediators (CCL28 and CCR10) Associated with the Progression of Oral Squamous Cell Carcinoma: A Cross-Sectional Investigation

Article

Author: Sivakumar, N ; Sivakumar, N. ; Mehta, Manjit Kour ; Selvam, Ramya ; Chandra, Shaleen ; Gupta, Shalini ; Fatima, Tanveer ; Singh, Diksha

Oral cancer ranks as the 16th most prevalent form of cancer worldwide and is a significant concern in Southeast Asia, primarily due to the extensive use of tobacco. Chemokines contribute to a wide range of illness situations. This study aimed to investigate the immunohistochemistry expression of CCL28 and its receptor CCR10 in oral squamous cell carcinoma and examine their relationship with tumor progression. This study retrospectively examined tissues of oral squamous cell carcinoma that were preserved by formalin fixation and paraffin embedding. The study includes two groups: Group I included 50 cases of OSCC with varying histological grades, whereas Group II comprised 50 samples of normal oral mucosa (NOM) obtained from healthy individuals who did not engage in any tobacco use. The cytoplasmic placement of the study groups allowed us to determine the expression patterns of CCL28 and CCR10. The study found a strong link between CCL28 and CCR10 immunohistochemical expression in oral squamous cell carcinoma. There were big differences in the amount of CCR10 staining in the 96 cases that showed positive immunoexpression. This shows that these two molecules have a big impact on how OSCC acts biologically. Various stages of oral squamous cell carcinoma and healthy oral mucosa exhibited simultaneous expression of CCL28 and CCR10. In summary, we can utilize CCR10 and CCL28 co-expression, along with other biomarkers, to aid in the prognosis of oral squamous cell carcinoma (OSCC).

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CCR10

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