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JACKSON CENTER, PA / ACCESSWIRE / October 4, 2023 / Halberd Corporation's (OTC PINK:HALB) proprietary nasal spray testing results to mitigate the effects of Traumatic Brain Injury (TBI) at Mississippi State University (MSU) replicated the earlier dramatic results. The latest testing results were very similar to the initial proof of concept testing: 25% reduction in Neuron Specific Enolase and 52.3% reduction in the levels of Glial Fibrillary Acid Protein compared to the control group. Neuron Specific Enolase (NSE) is a biomarker of neuronal damage and is a known predictor of the ultimate outcomes of TBI. Glial Fibrillary Acid Protein (GFAP) is a widely used indicator of ongoing neurodegeneration resulting from traumatic brain injury. Reductions of NSE and GFAP are associated with better neurological outcomes from head trauma. Mitchell S. Felder, M.D., Halberd Corporation's Chief Technology Officer and a board-certified attending neurologist, stated, "I believe that the Halberd nasal spray could be a major breakthrough in the treatment of TBI and possibly other neurological disease states. The nasal spray in our testing reduced NSE (Neuron Specific Enolase) by 4.1% at day 3, and 29.2% at day 6 in the study! There was also a profound improvement in GFAP (Glial Fibrillary Acidic Protein) of 25.0% at day 3, and 52.3% at day 6 in the test subject animals! GFAP is used by physicians worldwide for the diagnosis, treatment and prognosis of TBI. This has the potential for greatly changing the prognosis in TBI victims." Dr. Felder continued, "For now, the objective is to perfect the formulation for the best possible outcome. The present results are demonstrably beneficial and incredibly encouraging. We look forward to feedback from the Department of Defense as to further strategies, while we continue this study at MSU." William A. Hartman, Chairman, President and CEO of Halberd Corporation, remarked, "The results from these replication tests at MSU are very encouraging and indicate that we are on the right track to finding an effective treatment in mitigating the effects of TBI, particularly with timely administration and even when administered within two weeks of the injury. The nasal spray has the unique potential for self-administration within minutes of a TBI incident, when the victim is in a remote location. Our objective is to be able to provide an effective, easy-to-use, point of incidence treatment for TBI to ameliorate the chemical imbalance in the brain, which can lead to numerous neurodegenerative diseases and suicide ideation." To get the latest news on Halberd's exciting developments, subscribe by submitting this. ( ) For more information please contact: William A. Hartman w.hartman@halberdcorporation.com support@halberdcorporation.com Twitter:@HalberdC About Mississippi State University College of Veterinary Medicine (CVM). Mississippi State University College of Veterinary Medicine (MSU CVM) was founded in 1974 The CVM has a total of six locations and serves all 82 counties in Mississippi as well as the entire Southeastern United States. The College's main campus is in Starkville and includes the Wise Center, which houses its main teaching hospital, the Animal Health Center. The MSU CVM Department of Comparative Biomedical Sciences faculty and staff represent the basic scientific disciplines required for education of veterinarians. MSU CVM is committed to an ethical approach to treating animals with a genuine passion and drive. About Halberd Corporation. Halberd Corporation (OTC PINK:HALB), is a publicly traded company on the OTC Market, and is in full compliance with OTC Market reporting requirements. Since its restructuring in April of 2020, Halberd has obtained exclusive worldwide rights to three issued patents and has filed 22 related provisional, PCT, or utility patent applications to enhance its value to its stockholders and to attract the interests of potential development partners. Safe Harbor Notice Certain statements contained herein are "forward-looking statements" (as defined in the Private Securities Litigation Reform Act of 1995). The Company' cautions our readers that statements, and assumptions made in this news release constitute forward-looking statements and makes no guarantee of future performance. Forward-looking statements are based on estimates and opinions of management at the time the statements are made. These statements may address issues that involve significant risks, uncertainties and associated estimates made by management. Actual results could differ materially from current projections or implied results. Halberd Corporation undertakes no obligation to revise these statements following the date of this news release. (C) 2023, Halberd Corporation SOURCE: Halberd Corporation View source version on accesswire.com:

JACKSON CENTER, PA / ACCESSWIRE / September 20, 2023 / Halberd Corporation (OTC PINK:HALB) and Athena GTX, Inc, of Johnston, Iowa commenced collaboration on critical development of submissions for government contracts seeking proposals for the detection and treatment of traumatic brain injury (TBI). The initial focus will be on accelerating and fine-tuning Halberd's proprietary nasal spray for suppressing the effects of traumatic brain injury (TBI). In addition, consistent with the government request, this will include rapid detection and assessment technologies from Athena as a point of injury (POI) treatment for use by both the military, civilian first responders and contact sports participants. Halberd's nasal spray treatment is designed to suppress the detrimental cascading generation of excess inflammatory cytokines and neurotransmitters which result from progressive traumatic brain injury. Currently, no other product on the market addresses this need with a combination of 1.) a monoclonal antibody against glutamate, thereby decreasing extracellular glutamate (decreasing the excitatory neurotransmitter), 2.) a paranasal insulin counteracting hyperglycolosis and hyperkalemia allowing cerebral blood flow to keep up with brain oxygen demands after TBI, and 3.) a neurosteroid as a positive allosteric modulator, thereby slowing and inhibiting the binding of ligands to orthosteric binding sites. This acts to decrease metabolic demands, lowers intercranial pressure (ICP) and significantly decreases inflammation. The collaboration plan is to deploy the novel product as a simple nasal spray as a custom formulation allowing for easy and rapid administration in emergency situations, making it particularly valuable for use by military warfighters in theatre and contact sports participants. The research data to date are demonstrating the synergistic effectiveness of this approach (combo of neuroexcitation, hypermetabolism and inflammation/edema mitigations) in animals. In ongoing preclinical studies with IRB-approved protocols, we are showing exciting early data on efficacy in a rat model and soon will begin sheep studies at Mississippi State University. Results in test animals at zero, three, six and fourteen days after induced TBI impact have produced consistent reductions of two key biomarkers of TBI; a 19% reduction in Neuron Specific Enolase (NSE) and a 51% reduction in levels of Glial Fibrillary Acid Protein (GFAP). NSE is a biomarker of neuronal damage that has been shown to be a predictor of the ultimate outcome of TBI, and GFAP is an indicator of the induction of neuroinflammation and is also an indicator of neurodegeneration associated with Alzheimer's Disease, Parkinson's Disease, epileptic seizures, etc. Excess quantities of these elements have been linked to permanent changes in the brain associated with not only cognitive dysfunction, but potentially PTSD, suicide ideation, and other neurodegenerative diseases. This link to these other disease states is due to the commonality of the antigens demonstrably associated thereto. Athena has a long history of government contracting on innovative solutions, and designing and developing miniature monitoring devices for these markets with numerous FDA-cleared devices now on the market for target markets throughout the world. This partnership represents a significant step towards addressing the long-term health implications associated with traumatic brain injury. By harnessing the power of innovative medical solutions, Halberd and Athena aim to enhance the quality of life for those who have sustained traumatic brain injury. To get the latest news on Halberd's exciting developments, subscribe by submitting this. ( ). For more information please contact: William A. Hartman w.hartman@halberdcorporation.com support@halberdcorporation.com Twitter:@HalberdC About Athena GTX, Inc. Athena GTX is a certified DoD small business with Corporate Headquarters in Johnston, Iowa. Athena focuses development on wearables and highly mobile, wirelessly connected monitoring technologies, and transitioning those to key markets to meet unmet needs of first responders worldwide. Wireless Patient Monitoring - Athena GTX connects patient and provider About - Athena GTX® Inc. About Halberd Corporation. Halberd Corporation (OTC PINK:HALB), is a publicly traded company on the OTC Market, and is in full compliance with OTC Market reporting requirements. Since its restructuring in April of 2020, Halberd has obtained exclusive worldwide rights to three issued patents and has filed 22 related provisional, PCT, or utility patent applications to enhance its value to its stockholders and to attract the interests of potential development partners. Safe Harbor Notice Certain statements contained herein are "forward-looking statements" (as defined in the Private Securities Litigation Reform Act of 1995). The Company' cautions our readers that statements, and assumptions made in this news release constitute forward-looking statements and makes no guarantee of future performance. Forward-looking statements are based on estimates and opinions of management at the time the statements are made. These statements may address issues that involve significant risks, uncertainties and associated estimates made by management. Actual results could differ materially from current projections or implied results. Halberd Corporation undertakes no obligation to revise these statements following the date of this news release. (C) 2023, Halberd Corporation SOURCE: Halberd Corporation View source version on accesswire.com:

Anecdotal Results of Halberd's Nasal Spray Reveals Demonstrably Significant Reduction of Traumatic Brain Injury Markers JACKSON CENTER, PA / ACCESSWIRE / September 6, 2023 / Halberd Corporation's (OTC PINK:HALB) research at Mississippi State University (MSU) has shown significant reduction in two key markers of traumatic brain injury (TBI) in early testing of Halberd's patent-pending nasal spray to mitigate the effects of TBI. Anecdotal data in preliminary testing reveals a 20% reduction in Neuron Specific Enolase and a 50% reduction in the levels of Glial Fibrillary Acid Protein compared to the control group. Neuron Specific Enolase (NSE) is a biomarker of neuronal damage that has been shown to be a predictor of the ultimate outcomes of TBI. Glial Fibrillary Acid Protein (GFAP) is an indicator of the induction of neuroinflammation and is increased following traumatic brain injury. It is also thought to be an indicator of ongoing neurodegeneration related to numerous other diseases, Reductions of NSE and GFAP are associated with better neurological outcomes from head trauma. Dr. Russell Carr, professor at Mississippi State University Veterinary College and lead investigator, stated, "The research testing the effectiveness of the novel nasal therapeutic to treat the negative effects induced by traumatic brain injury has made significant progress. At this point, we have completed the impacts and have collected tissues. While the analysis of all regions is not complete, the results for the cerebral cortex strongly suggest that nasal administration of the therapeutic following a significant head impact greatly reduces the markers for cellular damage and neuroinflammation. These data are not complete as we intend to analyze the hippocampus as well as plan to repeat the experiment to ensure scientific validity." Mitchell S. Felder, M.D., Halberd's Chief Technology Officer, noted, "These are very exciting preliminary results. To the best of my knowledge, this is the only documented therapeutic pathophysiologic ameliorations for traumatic brain injury. This may also have a great deal of utility in the treatment of brain tumors, strokes and epilepsy, besides possibly preventing the development of cognitive dysfunction, seizures and TBI clinical symptomatology in head trauma." William A. Hartman, Chairman, President and CEO of Halberd Corporation, remarked, "The breakthrough testing to date at MSU is showing the timely application of Halberd's nasal spray within hours of a traumatic brain injury can potentially mitigate factors associated with long-term neurodegeneraton, often leading to Alzheimer's Disease, Parkinson's Disease, Epileptic seizures, PTSD, etc. We expect to fine tune and complete the current testing protocol as well as cognitive testing before commencing such treatment on larger animals. We look forward to relaying these results to the CDC, ARPA-H, DARPA and our Congressman. Communication with the FDA will be coordinated by mdi Consultants, Inc. to ensure the most expeditious review. "This product could have massive benefit to contact sports participants, such as football, hockey, and soccer, as well as the military and PTSD victims, and reduce the 50,000 depression-related suicides each year in the United States. This product has been shown to be truly revolutionary in early testing. We are committed to completing the pre-clinical testing at MSU to fully demonstrate the medical benefits of this product." To get the latest news on Halberd's exciting developments, subscribe by submitting this. ( ) For more information please contact: William A. Hartman w.hartman@halberdcorporation.com support@halberdcorporation.com Twitter:@HalberdC About Mississippi State University College of Veterinary Medicine (CVM). Mississippi State University College of Veterinary Medicine (MSU CVM) was founded in 1974 The CVM has a total of six locations and serves all 82 counties in Mississippi as well as the entire Southeastern United States. The College's main campus is in Starkville and includes the Wise Center, which houses its main teaching hospital, the Animal Health Center. The MSU CVM Department of Comparative Biomedical Sciences faculty and staff represent the basic scientific disciplines required for education of veterinarians. MSU CVM is committed to an ethical approach to treating animals with a genuine passion and drive. About Halberd Corporation. Halberd Corporation (OTC PINK:HALB), is a publicly traded company on the OTC Market, and is in full compliance with OTC Market reporting requirements. Since its restructuring in April of 2020, Halberd has obtained exclusive worldwide rights to three issued patents and has filed 22 related provisional, PCT, or utility patent applications to enhance its value to its stockholders and to attract the interests of potential development partners. Safe Harbor Notice Certain statements contained herein are "forward-looking statements" (as defined in the Private Securities Litigation Reform Act of 1995). The Company' cautions our readers that statements, and assumptions made in this news release constitute forward-looking statements and makes no guarantee of future performance. Forward-looking statements are based on estimates and opinions of management at the time the statements are made. These statements may address issues that involve significant risks, uncertainties and associated estimates made by management. Actual results could differ materially from current projections or implied results. Halberd Corporation undertakes no obligation to revise these statements following the date of this news release. (C) 2023, Halberd Corporation SOURCE: Halberd Corporation View source version on accesswire.com: