IGHE x FCER1A

Last update 08 May 2025

Basic Info

Related Targets

IGHEFCER1A

100 Clinical Results associated with IGHE x FCER1A

100 Translational Medicine associated with IGHE x FCER1A

0 Patents (Medical) associated with IGHE x FCER1A

Literatures (Medical) associated with IGHE x FCER1A

01 Apr 2013·Veterinary Immunology and ImmunopathologyQ3 · AGRICULTURAL & FORESTRY SCIENCE

Immunogenomic analysis of insect bite hypersensitivity in a model horse population

Q3 · AGRICULTURAL & FORESTRY SCIENCE

Article

Author: Jan Futas ; Jan Matiasovic ; Karla Stejskalova ; Ladislav Dusek ; Marie Klumplerova ; Petr Horin ; Eliane Isabelle Marti ; Eva Janova ; Mirko Vyskocil ; Olga Bobrova ; Marketa Sedlinska ; Leona Vychodilova ; Michaela Cvanova ; Jarmila Osickova

Equine insect bite hypersensitivity (IBH) is a seasonal IgE-mediated dermatosis caused by bites of insects of the genus Culicoides. A familial predisposition for the disease has been shown but, except for the MHC, the genes involved have not been identified so far. An immunogenomic analysis of IBH was performed in a model population of Old Kladruby horses, all living in the same environment. Clinical signs of IBH were used as phenotypic manifestation of IBH. Furthermore, total serum IgE levels were determined in the sera of these horses and used as an independent phenotypic marker for the immunogenetic analysis. Single nucleotide polymorphisms (SNPs) in candidate immunity-related genes were used for association analyses. Genotypes composed of two to five genes encoding interferon gamma -IFNG, transforming growth factor beta 1 -TGFB1, Janus kinase 2 -JAK2, thymic stromal lymphopoietin -TSLP, and involucrin -IVL were associated with IBH, indicating a role of the genes in the pathogenesis of IBH. These findings were supported by analysis of gene expression in skin biopsies of 15 affected and 15 unaffected horses. Two markers associated with IBH, IFNG and TGFB1, showed differences in mRNA expression in skin biopsies from IBH-affected and non-affected horses (p<0.05). Expression of the gene coding for the CD14 receptor molecule -CD14 was different in skin biopsies at p<0.06. When total IgE levels were treated as binary traits, genotypes of IGHE, ELA-DRA, and IL10/b were associated with this trait. When treated as a continuous trait, total IgE levels were associated with genes IGHE, FCER1A, IL4, IL4R, IL10, IL1RA, and JAK2. This first report on non-MHC genes associated with IBH in horses is thus supported by differences in expression of genes known to play a role in allergy and immunity.

01 Apr 2012·Tissue Antigens

Genomic analysis of resistance/susceptibility to melanoma in Old Kladruber greying horses

Letter

Author: L. Dusek ; P. Horin ; M. Vyskocil ; L. Vychodilova ; J. Futas ; M. Vranova ; B. Hofmanova ; I. Vrtkova ; L. Putnova ; I. Majzlik ; J. Muzik

Associations between microsatellite and candidate gene polymorphic markers and the presence of melanoma were analyzed in Old Kladruber greying horses.Fifty microsatellite markers located on 29 out of 31 pairs of horse chromosomes (ECA) and 36 polymorphic markers located in 26 expressed candidate genes (CD14, CTNNAL1, ELA-Eqca-DRA, ELA-Eqca-DQA, FcER1A, GBP1, HRH4, IGHE, IFNG, IL1B, IL1RN, IL4, IL4R, IL10, IL13, IL12A, IL12B, IL12RB2, IL23A, MMP16, TGFB1, TGFB3, TLR4, MC1R, AS1P and STX17) were genotyped.Anal. of genotypes composed of multiple markers not only confirmed single gene associations, but also suggested effects of other immunity-related genes in the presence of melanoma, IL12A, coding for the interleukin-12 p35 subunit and specific major histocompatibility complex Eqca haplotypes.Although some risks of false pos. associations were reduced by corrections for age and multiple comparisons with high P values, the results obtained provide only preliminary evidence that immunity-related genes might be involved in mechanisms of the horse melanoma.The markers identified can be investigated as tools for designing a conservation program aiming to reduce incidence of melanoma without reducing population diversity and specificity.

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