Synonyms Fc epsilon receptor Ia, Fc fragment of IgE receptor Ia, Fc fragment of IgE, high affinity I, receptor for; alpha polypeptide + [8] |
Introduction High-affinity receptor for immunoglobulin epsilon/IgE. Mediates IgE effector functions in myeloid cells. Upon IgE binding and antigen/allergen cross-linking initiates signaling pathways that lead to myeloid cell activation and differentiation. On mast cells, basophils and eosinophils stimulates the secretion of vasoactive amines, lipid mediators and cytokines that contribute to inflammatory response, tissue remodeling and cytotoxicity against microbes. Triggers the immediate hypersensitivity response to allergens as a host defense mechanism against helminth parasites, pathogenic bacteria and venom toxicity. When dysregulated, it can elicit harmful life-threatening allergic and anaphylactic reactions. |
Target |
Mechanism FCER1A agonists |
Active Org. |
Originator Org. |
Active Indication |
Inactive Indication- |
Drug Highest PhaseApproved |
First Approval Ctry. / Loc. US |
First Approval Date25 Jul 1974 |
Target |
Mechanism CD23 antagonists [+2] |
Active Org.- |
Originator Org. |
Active Indication- |
Drug Highest PhaseDiscontinued |
First Approval Ctry. / Loc.- |
First Approval Date20 Jan 1800 |
Mechanism Envelope (E) protein modulators [+1] |
Active Org.- |
Originator Org. |
Active Indication- |
Inactive Indication |
Drug Highest PhasePending |
First Approval Ctry. / Loc.- |
First Approval Date20 Jan 1800 |
Start Date01 Oct 2020 |
Sponsor / Collaborator |
Start Date01 May 2019 |
Sponsor / Collaborator- |
Start Date14 Mar 2019 |
Sponsor / Collaborator |