Synonyms Deoxyadenosine kinase, mitochondrial, deoxyguanosine kinase, Deoxyguanosine kinase, mitochondrial + [2] |
Introduction Phosphorylates deoxyguanosine and deoxyadenosine in the mitochondrial matrix, with the highest efficiency for deoxyguanosine (PubMed:8692979, PubMed:8706825, PubMed:11687801, PubMed:17073823, PubMed:23043144). In non-replicating cells, where cytosolic dNTP synthesis is down-regulated, mtDNA synthesis depends solely on DGUOK and TK2. Phosphorylates certain nucleoside analogs (By similarity). Widely used as target of antiviral and chemotherapeutic agents. |
Target |
Mechanism DCK inhibitors [+1] |
Active Org. |
Originator Org. |
Active Indication |
Drug Highest PhasePhase 2 |
First Approval Ctry. / Loc.- |
First Approval Date20 Jan 1800 |
Start Date01 Nov 2023 |
Sponsor / Collaborator |
Start Date31 Oct 2023 |
Sponsor / Collaborator |
Start Date30 Jun 2023 |
Sponsor / Collaborator |