LAMP-2

Rocket Pharmaceuticals will have to wait another three months for an FDA decision on its investigational gene therapy for severe leukocyte adhesion deficiency-I (LAD-I). The US regulator is now expected to determine whether to approve Kresladi (marnetegragene autotemcel) by June 30 to allow more time to review "clarifying" information about the company's chemistry, manufacturing, and controls (CMC) process."We remain confident and focused on making this therapy available for patients as quickly as possible," stated CEO Gaurav Shah. According to Rocket, the FDA has also confirmed that it does not intend to convene an advisory committee meeting to discuss the filing, which was granted a priority review last October.The gene therapy, also known as RP-L201, contains patient-derived haematopoietic stem cells modified with a lentiviral vector to deliver a functional ITGB2 gene, which encodes human CD18 receptor to facilitate leukocyte adhesion and ability to move out of blood vessels to fight infection.In September, Rocket completed a global Phase I/II trial of the treatment in nine paediatric patients with severe LAD-I, according to ClinicalTrials.gov. The company says all primary and secondary endpoints were met with Kresladi demonstrating 100% overall survival at one-year post-infusion, as well as for the entire 12 to 24 months of follow-up.Compared with pre-treatment history, it said Kresladi also showed "large decreases" in the incidence of significant infections, and there was evidence of resolution of LAD-I-related skin lesions and restoration of wound repair capabilities. The gene therapy was "very well tolerated" in all patients, none of whom suffered serious adverse events related to treatment.Company shares soared last September announced plans to raise $175 million in an upsized public offering. Around the same time, it initiated a pivotal Phase II to support accelerated approval of its RP-A501 gene therapy for Danon disease, a rare X-linked inherited disorder caused by mutations in the LAMP-2 gene.

Agreement reached with FDA on Phase 2 pivotal study design of RP-L301 for PKD to support accelerated approval; Initiating single-arm, 10-patient pivotal study with primary endpoint of ≥1.5 point Hgb improvement at 12 months Initiated Phase 2 pivotal trial of RP-A501 for Danon Disease following FDA alignment Initiated Phase 1 study of RP-A601 for PKP2-ACM FDA accepted BLA with Priority Review for KRESLADITM (marnetegragene autotemcel) for severe LAD-I; PDUFA target action date is March 31, 2024 Product filings for RP-L102 for Fanconi Anemia anticipated in the first half of 2024 in the U.S. and Europe Cash, cash equivalents and investments of approximately $437.2M; expected operational runway through 2025 CRANBURY, N.J.--(BUSINESS WIRE)-- Rocket Pharmaceuticals, Inc. (NASDAQ: RCKT), a leading late-stage biotechnology company advancing an integrated and sustainable pipeline of genetic therapies for rare disorders with high unmet need, today reported financial results for the quarter ending September 30, 2023, and updates from the Company’s key pipeline developments, business operations and upcoming milestones. “I’m very pleased with Rocket’s results this quarter, as we realized significant regulatory milestones across our pipeline, including reaching FDA alignment on the study design for the 10-patient Phase 2 pivotal trial of RP-L301 for the treatment of severe PKD and securing the FDA’s acceptance of Rocket’s BLA for RP-L201, now named KRESLADITM, for the treatment of severe LAD-I,” said Gaurav Shah, M.D., Chief Executive Officer, Rocket Pharma. “At the same time, we initiated the Phase 2 pivotal trial of RP-A501 for Danon Disease following FDA alignment and the Phase 1 study of RP-A601 for PKP2-ACM, which move us substantially closer to delivering potential one-time, curative therapies to patients facing these two devastating cardiac diseases.” Dr. Shah continued, “As we bring 2023 to a close, we have made remarkable progress across the breadth of our AAV cardiovascular and LV hematology portfolios. Four programs have now reached pivotal studies, one of which is under review for approval, thanks to strong collaboration with health authorities and scientific partners, as we collectively seek to fulfill the high unmet needs of patients with rare and life-threatening diseases.” Key Pipeline and Operational Updates AAV Cardiovascular Portfolio Danon Disease Initiated Phase 2 pivotal trial of RP-A501 for Danon Disease following FDA alignment. The global Phase 2 multi-center trial is a single arm study with an external comparator arm and includes 12 male patients with Danon Disease. The trial is evaluating the safety and efficacy of RP-A501 at a dose level of 6.7 x 1013 GC/kg and includes a pediatric safety run-in (n=2). The co-primary endpoint is composed of LAMP2 protein expression and left ventricular (LV) mass index and will be assessed at 12 months for accelerated approval. Supported peer-reviewed expert consensus paper to increase awareness of diagnosis and clinical management of patients with Danon Disease. “International Consensus on Differential Diagnosis and Management of Patients with Danon Disease: JACC State-of-the-Art Review” was published in the Journal of the American College of Cardiology. Highlights of the publication include a review of diagnosing Danon Disease emphasizing the importance of genetic testing upon clinical suspicion, natural history, management recommendations and recent advances in potential gene therapy treatment. Filed Clinical Trial Application (CTA)/Investigational Medicinal Product Dossier (IMPD) for RP-A501 to EMA and MHRA. Rocket is working towards initiation of Phase 2 pivotal trial activities in Europe and the UK. PKP2 Arrhythmogenic Cardiomyopathy (PKP2-ACM) Initiated Phase 1 trial of RP-A601. The multi-center Phase 1, dose escalation trial will evaluate the safety and preliminary efficacy of RP-A601 in at least six adult PKP2-ACM patients with ICDs and overall high risk for arrhythmias. The study will assess the impact of RP-A601 on PKP2 myocardial protein expression, cardiac biomarkers, and clinical predictors of life-threatening ventricular arrhythmias and sudden cardiac death. Patients in the dose-escalation trial will receive a single dose of RP-A601. The starting dose will be 8 x 1013 GC/kg. LV Hematology Portfolio Leukocyte Adhesion Deficiency-I (LAD-I) BLA accepted by FDA with Priority Review for KRESLADITM (marnetegragene autotemcel). Based on the positive top-line efficacy and safety data from the global Phase 1/2 study, the FDA accepted the BLA and also granted Priority Review for KRESLADITM, also known as RP-L201. This represents Rocket’s first product filing and is a significant milestone for both the Company and patients whose only current available treatment option is bone marrow transplant, which has substantial morbidity and mortality, and may not be available in time. The PDUFA date set by the FDA is March 31, 2024. Fanconi Anemia (FA) Product filings for RP-L102 anticipated in the first half of 2024 in the U.S. and Europe. Rocket is finalizing the CMC package with the FDA. Pyruvate Kinase Deficiency (PKD) Reached agreement with FDA on study design of Phase 2 pivotal trial of RP-L301. Based on positive safety and efficacy data from the Phase 1 study, Rocket has aligned with the FDA on the pivotal study design to support accelerated approval and is initiating a 10-patient, single-arm Phase 2 pivotal trial with a primary endpoint of ≥1.5 point Hgb improvement at 12 months. Presented positive updated clinical data from Phase 1 trial of RP-L301 at the ESGCT Annual Meeting. Updated data demonstrated sustained efficacy in both adult patients with up to 36 months follow-up. Hemoglobin improvement relative to pre-treatment baseline was observed in both patients in the pediatric cohort with up to six months of available follow-up. Results also indicated favorable safety pro RP-L301 in all four patients treated in the Phase 1 study. Operational Updates Published peer-reviewed risk assessment demonstrating low incidence of busulfan-related secondary malignancies in pediatric transplant recipients. “Busulfan and Subsequent Malignancy: An Evidence-based Risk Assessment” was published in Pediatric Blood & Cancer. Busulfan is utilized as conditioning prior to gene therapy in nonmalignant hematologic and related disorders. Researchers conducted a literature-based assessment of busulfan and subsequent late effects, concluding the incidence of busulfan-related secondary malignancies has been less than 1% in pediatric transplant recipients, and that the incidence of secondary cancers in pediatric patients receiving single-agent busulfan in non-malignant settings is likely to be substantially lower than 1%. Raised net proceeds of $188.9M through public offering. On September 15, 2023, the Company completed a public offering of approximately 9.5 million shares of our common stock at a public offering price of $16.00 per share and pre-funded warrants to purchase 3.1 million shares of common stock at a price of $15.99 per warrant. The gross proceeds to Rocket from the public offering were approximately $201.3 million, net of $12.4 million of offering costs, commissions, legal and other expenses for net proceeds from the offering of $188.9 million. Upcoming Investor Conferences Stifel Healthcare Conference 2023, November 15 6th Annual Evercore ISI HealthCONx Conference 2023, November 30 Third Quarter Financial Results Cash position. Cash, cash equivalents and investments as of September 30, 2023, were $437.2 million. R&D expenses. Research and development expenses were $46.8 million for the three months ended September 30, 2023, compared to $43.4 million for the three months ended September 30, 2022. The increase in R&D expenses was primarily driven by increases in compensation and benefits expenses of $4.5 million due to increased R&D headcount, clinical trial expenses of $7.4 million, license expenses of $2.2 million, and non-cash stock-based compensation of $1.6 million. Increases noted were offset by decreases in manufacturing and development costs of $9.0 million and cost of direct materials of $3.3 million. G&A expenses. General and administrative expenses were $18.6 million for the three months ended September 30, 2023, compared to $15.1 million for the three months ended September 30, 2022. The increase in G&A expenses was primarily driven by increases in commercial preparation expenses which consists of commercial strategy, medical affairs, market development and pricing analysis of $2.5 million and non-cash stock compensation expense of $1.0 million, partially offset by reduction in acquisition related expenses of $1.3 million. Net loss. Net loss was $61.9 million or $0.75 per share (basic and diluted) for the three months ended September 30, 2023, compared to $57.8 million or $0.87 per share (basic and diluted) for the three months ended September 30, 2022. Shares outstanding. 90,146,602 shares of common stock were outstanding as of September 30, 2023. Financial Guidance Cash position. As of September 30, 2023, Rocket had cash, cash equivalents and investments of $437.2 million. Rocket expects such resources will be sufficient to fund its operations through 2025, including producing AAV cGMP batches at the Company’s Cranbury, N.J. R&D and manufacturing facility and continued development of its six clinical and/or preclinical programs. About Rocket Pharmaceuticals, Inc. Rocket Pharmaceuticals, Inc. (NASDAQ: RCKT) is advancing an integrated and sustainable pipeline of investigational genetic therapies designed to correct the root cause of complex and rare disorders. The Company’s platform-agnostic approach enables it to design the best therapy for each indication, creating potentially transformative options for patients afflicted with rare genetic diseases. Rocket's clinical programs using lentiviral (LV) vector-based gene therapy are for the treatment of Fanconi Anemia (FA), a difficult to treat genetic disease that leads to bone marrow failure and potentially cancer, Leukocyte Adhesion Deficiency-I (LAD-I), a severe pediatric genetic disorder that causes recurrent and life-threatening infections which are frequently fatal, and Pyruvate Kinase Deficiency (PKD), a rare, monogenic red blood cell disorder resulting in increased red cell destruction and mild to life-threatening anemia. Rocket’s first clinical program using adeno-associated virus (AAV)-based gene therapy is for Danon Disease, a devastating, pediatric heart failure condition. Rocket also is developing AAV-based gene therapy programs in PKP2-arrhythmogenic cardiomyopathy (ACM) and BAG3-associated dilated cardiomyopathy (DCM). For more information about Rocket, please visit . Rocket Cautionary Statement Regarding Forward-Looking Statements Various statements in this release concerning Rocket’s future expectations, plans and prospects, including without limitation, Rocket’s expectations regarding the safety and effectiveness of product candidates that Rocket is developing to treat Fanconi Anemia (FA), Leukocyte Adhesion Deficiency-I (LAD-I), Pyruvate Kinase Deficiency (PKD), Danon Disease (DD) and other diseases, the expected timing and data readouts of Rocket’s ongoing and planned clinical trials, the expected timing and outcome of Rocket’s regulatory interactions and planned submissions, Rocket’s plans for the advancement of its Danon Disease program, including its planned pivotal trial, and the safety, effectiveness and timing of related pre-clinical studies and clinical trials, may constitute forward-looking statements for the purposes of the safe harbor provisions under the Private Securities Litigation Reform Act of 1995 and other federal securities laws and are subject to substantial risks, uncertainties and assumptions. You should not place reliance on these forward-looking statements, which often include words such as "believe," "expect," "anticipate," "intend," "plan," "will give," "estimate," "seek," "will," "may," "suggest" or similar terms, variations of such terms or the negative of those terms. Although Rocket believes that the expectations reflected in the forward-looking statements are reasonable, Rocket cannot guarantee such outcomes. Actual results may differ materially from those indicated by these forward-looking statements as a result of various important factors, including, without limitation, Rocket’s ability to monitor the impact of COVID-19 on its business operations and take steps to ensure the safety of patients, families and employees, the interest from patients and families for participation in each of Rocket’s ongoing trials, our expectations regarding the delays and impact of COVID-19 on clinical sites, patient enrollment, trial timelines and data readouts, our expectations regarding our drug supply for our ongoing and anticipated trials, actions of regulatory agencies, which may affect the initiation, timing and progress of pre-clinical studies and clinical trials of its product candidates, Rocket’s dependence on third parties for development, manufacture, marketing, sales and distribution of product candidates, the outcome of litigation, and unexpected expenditures, as well as those risks more fully discussed in the section entitled "Risk Factors" in Rocket’s Annual Report on Form 10-K for the year ended December 31, 2022, filed February 28, 2023 with the SEC and subsequent filings with the SEC including our Quarterly Reports on Form 10-Q. Accordingly, you should not place undue reliance on these forward-looking statements. All such statements speak only as of the date made, and Rocket undertakes no obligation to update or revise publicly any forward-looking statements, whether as a result of new information, future events or otherwise. Three Months Ended September 30, Nine Months Ended September 30, 2023 2022 2023 2022 Operating expenses: Research and development $ 46,844 $ 43,383 $ 144,598 $ 115,533 General and administrative 18,585 15,105 51,782 39,728 Total operating expenses 65,429 58,488 196,380 155,261 Loss from operations (65,429 ) (58,488 ) (196,380 ) (155,261 ) Interest expense (469 ) (465 ) (1,405 ) (1,395 ) Interest and other income, net 1,720 1,353 4,474 2,644 Accretion of discount and amortization of premium on investments, net 2,279 (156 ) 7,376 (1,128 ) Net loss $ (61,899 ) $ (57,756 ) $ (185,935 ) $ (155,140 ) Net loss per share - basic and diluted $ (0.75 ) $ (0.87 ) $ (2.30 ) $ (2.37 ) Weighted-average common shares outstanding - basic and diluted 82,636,120 66,215,535 80,865,658 65,406,844 September 30, 2023 December 31, 2022 Cash, cash equivalents, and investments $ 437,171 $ 399,670 Total assets 598,762 551,807 Total liabilities 57,676 62,121 Total stockholders' equity 541,086 489,686

CRANBURY, N.J.--(BUSINESS WIRE)-- Rocket Pharmaceuticals, Inc. (NASDAQ: RCKT), a leading late-stage biotechnology company advancing an integrated and sustainable pipeline of genetic therapies for rare disorders with high unmet need, today announced presentations at the 30th Annual Congress of the European Society of Gene & Cell Therapy (ESGCT) in Brussels, Belgium, taking place October 24-27. Updated data will be presented from the Phase 1 clinical trial of RP-L301 for Pyruvate Kinase Deficiency (PKD). Previously disclosed data will be presented from the Phase 2 pivotal trial of RP-L102 for Fanconi Anemia, Phase 1 trial of RP-A501 for Danon Disease and preclinical studies supporting the Phase 1 trial of RP-A601 for PKP2 arrhythmogenic cardiomyopathy (PKP2-ACM). Kinnari Patel, Pharm.D., MBA, President and Chief Operating Officer, Rocket Pharma, will also give an Invited Talk about the importance of collaboration with and commitment to patients in gene therapy development. Details for the Invited Talks and oral presentations are as follows: Title: Global Phase 1 Study Results of Lentiviral Mediated Gene Therapy for Severe Pyruvate Kinase Deficiency Session: Lentiviral & Integrative Vectors​ Presenter: Julián Sevilla M.D., Ph.D., Fundación para la Investigación Biomédica, Hospital Infantil Universitario Niño Jesús Session date and time: Tuesday, October 24, 5:00 p.m. – 7:00 p.m. CEST Presentation number: OR05 Title: Embracing Collaboration and Commitment to Patients to Drive Gene Therapy Forward​ Session: Accessibility of Gene Therapy Presenter: Kinnari Patel, Pharm.D., MBA, President and Chief Operating Officer, Rocket Pharma Session date and time: Wednesday, October 25, 2:30 p.m. – 5:00 p.m. CEST Presentation number: INV31 Title: Molecular, Cellular and Clinical Implications of Lentiviral-Mediated Gene Therapy in Patients with Fanconi Anemia Session: Hematopoietic Diseases Gene Therapy Presenter: Paula Río, Ph.D., CIEMAT/CIBERER/IIS. F. Jiménez Díaz Session date and time: Thursday, October 26, 9:00 a.m. – 10:30 a.m. CEST Presentation number: OR41 Title: Gene Therapy for Patients with Danon Disease: First in Man Experience Session: Cardiovascular & Muscular Diseases Presenter: Jonathan Schwartz, M.D., Chief Gene Therapy Officer, Rocket Pharma Session date and time: Friday, October 27, 11:00 a.m. – 1:00 p.m. CEST Presentation number: INV81 Details for the poster presentation are as follows: Title: Preclinical Efficacy & Safety of AAVrh.74-PKP2a (RP-A601): Gene Therapy for PKP2-associated Arrhythmogenic Cardiomyopathy Session: AAV & Non Integrative Vectors Presenter: Bitha Narayanan, Ph.D., Senior Director, Nonclinical R&D, Rocket Pharma Session dates and times: Wednesday, October 25, 5:00 p.m. – 6:15 p.m. CEST, and Thursday, October 26, 8:30 p.m. – 9:30 p.m. CEST Poster number: P067 Additional information can be found online at: . About Pyruvate Kinase Deficiency Pyruvate Kinase Deficiency (PKD) is a rare, monogenic red blood cell disorder resulting from a mutation in the PKLR gene encoding for the pyruvate kinase enzyme, a key component of the red blood cell glycolytic pathway. Mutations in the PKLR gene result in increased red blood cell destruction and the disorder ranges from mild to life-threatening anemia. PKD has an estimated prevalence of 4,000 to 8,000 patients in the U.S. and Europe. Children are the most commonly and severely affected subgroup of patients. Patients with PKD have a high unmet medical need, as currently available treatments include splenectomy and red blood cell transfusions, which are associated with immune defects and chronic iron overload. Recently, mitapivat, an oral enzyme activator, was approved for use in adult patients, however its efficacy is limited in more severely-afflicted patients, most notably in those who are splenectomized, transfusion-dependent, or whose disease results from deleterious mutations. RP-L301 was in-licensed from the Centro de Investigaciones Energéticas, Medioambientales y Tecnológicas (CIEMAT), Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER) and Instituto de Investigación Sanitaria de la Fundación Jiménez Díaz (IIS-FJD). About Fanconi Anemia Fanconi Anemia (FA) is a rare pediatric disease characterized by bone marrow failure, malformations, and cancer predisposition. The primary cause of death among patients with FA is bone marrow failure, which typically occurs during the first decade of life. Allogeneic hematopoietic stem cell transplantation (HSCT), when available, corrects the hematologic component of FA, but requires myeloablative conditioning. Graft-versus-host disease, a known complication of allogeneic HSCT, is associated with an increased risk of solid tumors, mainly squamous cell carcinomas of the head and neck region. Approximately 60-70% of patients with FA have a Fanconi Anemia complementation group A (FANCA) gene mutation, which encodes for a protein essential for DNA repair. Mutations in the FANCA gene lead to chromosomal breakage and increased sensitivity to oxidative and environmental stress. Increased sensitivity to DNA-alkylating agents such as mitomycin-C (MMC) or diepoxybutane (DEB) is a ‘gold standard’ test for FA diagnosis. Somatic mosaicism occurs when there is a spontaneous correction of the mutated gene that can lead to stabilization or correction of a FA patient’s blood counts in the absence of any administered therapy. Somatic mosaicism, often referred to as ‘natural gene therapy’ provides a strong rationale for the development of FA gene therapy because of the selective growth advantage of gene-corrected hematopoietic stem cells over FA cells. There is a high unmet medical need for patients with FA. About Danon Disease Danon Disease is a rare X-linked inherited disorder caused by mutations in the gene encoding lysosome-associated membrane protein 2 (LAMP-2), an important mediator of autophagy. This results in accumulation of autophagosomes and glycogen, particularly in cardiac muscle and other tissues, which ultimately leads to heart failure, and for male patients, frequent death during adolescence or early adulthood. It is estimated to have a prevalence of 15,000 to 30,000 patients in the U.S. and Europe. The only available treatment option for Danon Disease is cardiac transplantation, which is associated with substantial complications and is not considered curative. There is a high unmet medical need for patients with Danon Disease. About PKP2-Arrhythmogenic Cardiomyopathy (PKP2-ACM) PKP2-ACM is an inherited heart disease caused by mutations in the PKP2 gene and characterized by life-threatening ventricular arrhythmias, cardiac structural abnormalities, and sudden cardiac death. PKP2-ACM affects approximately 50,000 adults and children in the U.S. and Europe. Patients living with PKP2-ACM have an urgent unmet medical need, as current medical, implantable cardioverter defibrillator (ICD), and ablation therapies do not consistently prevent disease progression or arrhythmia recurrence, are associated with significant morbidity including inappropriate shocks and device and procedure-related complications, and do not address the underlying pathophysiology or genetic mutation. RP-A601 is being investigated as a one-time, potentially curative gene therapy treatment that may improve survival and quality of life for patients affected by this devastating disease. About Rocket Pharmaceuticals, Inc. Rocket Pharmaceuticals, Inc. (NASDAQ: RCKT) is advancing an integrated and sustainable pipeline of investigational genetic therapies designed to correct the root cause of complex and rare disorders. The Company’s platform-agnostic approach enables it to design the best therapy for each indication, creating potentially transformative options for patients afflicted with rare genetic diseases. Rocket's clinical programs using lentiviral vector (LV)-based gene therapy are for the treatment of Fanconi Anemia (FA), a difficult to treat genetic disease that leads to bone marrow failure and potentially cancer, Leukocyte Adhesion Deficiency-I (LAD-I), a severe pediatric genetic disorder that causes recurrent and life-threatening infections which are frequently fatal, and Pyruvate Kinase Deficiency (PKD), a rare, monogenic red blood cell disorder resulting in increased red cell destruction and mild to life-threatening anemia. Rocket’s first clinical program using adeno-associated virus (AAV)-based gene therapy is for Danon Disease, a devastating, pediatric heart failure condition. Rocket also is developing AAV-based gene therapy programs in PKP2-arrhythmogenic cardiomyopathy (ACM) and BAG3-associated dilated cardiomyopathy (DCM). For more information about Rocket, please visit . Rocket Cautionary Statement Regarding Forward-Looking Statements Various statements in this release concerning Rocket’s future expectations, plans and prospects, including without limitation, Rocket’s expectations regarding the safety and effectiveness of product candidates that Rocket is developing to treat Fanconi Anemia (FA), Leukocyte Adhesion Deficiency-I (LAD-I), Pyruvate Kinase Deficiency (PKD), Danon Disease (DD) and other diseases, the expected timing and data readouts of Rocket’s ongoing and planned clinical trials, the expected timing and outcome of Rocket’s regulatory interactions and planned submissions, Rocket’s plans for the advancement of its Danon Disease program, including its planned pivotal trial, and the safety, effectiveness and timing of related pre-clinical studies and clinical trials, may constitute forward-looking statements for the purposes of the safe harbor provisions under the Private Securities Litigation Reform Act of 1995 and other federal securities laws and are subject to substantial risks, uncertainties and assumptions. You should not place reliance on these forward-looking statements, which often include words such as "believe," "expect," "anticipate," "intend," "plan," "will give," "estimate," "seek," "will," "may," "suggest" or similar terms, variations of such terms or the negative of those terms. Although Rocket believes that the expectations reflected in the forward-looking statements are reasonable, Rocket cannot guarantee such outcomes. Actual results may differ materially from those indicated by these forward-looking statements as a result of various important factors, including, without limitation, Rocket’s ability to monitor the impact of COVID-19 on its business operations and take steps to ensure the safety of patients, families and employees, the interest from patients and families for participation in each of Rocket’s ongoing trials, our expectations regarding the delays and impact of COVID-19 on clinical sites, patient enrollment, trial timelines and data readouts, our expectations regarding our drug supply for our ongoing and anticipated trials, actions of regulatory agencies, which may affect the initiation, timing and progress of pre-clinical studies and clinical trials of its product candidates, Rocket’s dependence on third parties for development, manufacture, marketing, sales and distribution of product candidates, the outcome of litigation, and unexpected expenditures, as well as those risks more fully discussed in the section entitled "Risk Factors" in Rocket’s Annual Report on Form 10-K for the year ended December 31, 2022, filed February 28, 2023 with the SEC and subsequent filings with the SEC including our Quarterly Reports on Form 10-Q. Accordingly, you should not place undue reliance on these forward-looking statements. All such statements speak only as of the date made, and Rocket undertakes no obligation to update or revise publicly any forward-looking statements, whether as a result of new information, future events or otherwise.