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Last update 08 May 2025

HYOU1

Last update 08 May 2025

Basic Info

Synonyms

150 kDa oxygen-regulated protein, 170 kDa glucose-regulated protein, GRP-170

+ [7]

Introduction

Has a pivotal role in cytoprotective cellular mechanisms triggered by oxygen deprivation. May play a role as a molecular chaperone and participate in protein folding.

Drugs associated with HYOU1

HYOU1 inhibitors(Biomedical Sciences Research Center “Alexander Fleming”)

Target

HYOU1

Mechanism

HYOU1 inhibitors

Active Org.

Bsrc Alexander Fleming

Originator Org.

Bsrc Alexander Fleming

Active Indication

Fibrosis [+2]

Inactive Indication-

Drug Highest PhasePreclinical

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

100 Clinical Results associated with HYOU1

100 Translational Medicine associated with HYOU1

0 Patents (Medical) associated with HYOU1

333

Literatures (Medical) associated with HYOU1

01 Sep 2025·Comparative Biochemistry and Physiology Part D: Genomics and Proteomics

Identification and characterization of hsp70 gene family in Acrossocheilus fasciatus based on genome and full-length transcripts

Article

Author: Li, Tong ; Niyompano, Fidele ; Jiang, Xinqin ; Guo, Yongyao ; Luo, Ziwei ; Chen, Ye ; Zhao, Bo ; Chen, Junhao ; Wang, Shun

Global warming and temperature extremes are increasingly recognized as critical environmental stressors for aquatic species, particularly stream fish, which are becoming more vulnerable due to fluctuating water temperatures and a scarcity of thermal refuges. The hsp70 gene family plays a crucial role in maintaining cellular homeostasis and mediating stress responses, especially under thermal stress. However, the evolutionary dynamics and functional diversity of this gene family remain relatively unexplored in stream fish. In this study, we investigated the hsp70 gene family in Acrossocheilus fasciatus, an economically important stream fish, by integrating full-length transcriptome data with genomic. Through the use of genomic and full-length transcriptome sequencing, we refined the genome annotation of A. fasciatus and identified 18 hsp70 family members, including six novel genes previously unannotated in the genome. Phylogenetic, domain, and motif analyses revealed significant structural variation among these genes. Chromosomal localization demonstrated their distribution across multiple chromosomes, while synteny analysis confirmed evolutionary conservation with A. fasciatus, Danio rerio and Onychostoma macrolepis. RNA-seq and qRT-PCR analyses revealed that hsp70 genes showed minimal differential expression in brain tissue under acute thermal stress and in muscle tissue under chronic thermal stress. qRT-PCR analysis revealed significant differential expression of hsp70 genes in muscle tissue under acute thermal stress, with hspa8b, hspa13, and hyou1 exhibited marked upregulation, whereas hspa14 was significantly downregulated. These genes could serve as potential biomarkers. The integration of full-length transcriptome data with genomic information improved the precision of gene identification and genome annotation. These findings carry significant and far-reaching implications for advancing our comprehension of thermal stress in aquatic organisms, potentially informing and enhancing conservation and breeding initiatives.

01 Feb 2025·American Journal of Physiology-Renal Physiology

Excess dietary sodium restores electrolyte and water homeostasis caused by loss of the endoplasmic reticulum molecular chaperone, GRP170, in the mouse nephron

Article

Author: Marciszyn, Allison ; Porter, Aidan W ; Buck, Teresa M ; Subramanya, Arohan R ; Mutchler, Stephanie M ; Kleyman, Thomas R ; Hendershot, Linda M ; Vorndran, Hannah E ; Brodsky, Jeffrey L

Loss of the endoplasmic reticulum chaperone, GRP170, results in widespread kidney injury and induction of the unfolded protein response (UPR). We now show that sodium supplementation is able to at least partially restore electrolyte imbalance and reduce kidney injury markers in a sex-dependent manner.

01 Nov 2024·Science of The Total Environment

Positive selection in cilia-related genes may facilitate deep-sea adaptation of Thermocollonia jamsteci

Article

Author: Chen, Hao ; Wang, Jing ; Li, Chaolun ; Chen, Nansheng ; Liu, Shuya ; Hui, Min ; Xu, Qing ; Duan, Zelin

Deep-sea hydrothermal vents are characterized by high hydrostatic pressure, hypoxia, darkness and toxic substances. However, how organisms adapt to such extreme marine ecosystems remain poorly understood. We hypothesize that adaptive evolution plays an essential role in generating novelty for evolutionary adaptation to the deep-sea environment because adaptive evolution has been found to be critical for species origin and evolution. In this project, the chromosome-level genome of the deep-sea hydrothermal vent gastropod T. jamsteci was constructed for the first time to examine molecular mechanisms of its adaptation to the deep-sea environment. The genome size was large (2.54 Gb), ranking at the top of all species in the Vetigastropoda subclass, driven primarily by the bursts of transposable elements (TEs). The transposition of TEs may also trigger chromosomal changes including both inter-chromosomal fusions and intra-chromosomal activities involving chromosome inversions, rearrangements and fusions, as revealed by comparing the genomes of T. jamsteci and its closely related shallow-sea species Gibbula magus. Innovative changes including the expansion of the ABC transporter gene family that may facilitate detoxification, duplication of genes related to endocytosis, immunity, apoptosis, and anti-apoptotic domains that may help T. jamsteci fight against microbial pathogens, were identified. Furthermore, comparative analysis identified positive selection signals in a large number of genes including the hypoxia up-regulated protein 1, which is a chaperone that may promote adaptation of the T. jamsteci to hypoxic deepsea environments, hox2, Rx2, Pax6 and cilia-related genes BBS1, BBS2, BBS9 and RFX4. Notably, because of the critical importance of cilia and IFT in development, positive selection in cilia-related genes may play a critical role in facilitating T. jamsteci to adapt to the high-pressure deep-sea ecosystem. Results from this study thus revealed important molecular clues that may facilitate further research on the adaptation of molluscs to deep-sea hydrothermal vents.

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HYOU1

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