α-Klotho

Renowned Biotech Leader to Contribute Expertise in Neuroscience and Therapeutics DevelopmentNEW YORK, Sept. 29, 2024 (GLOBE NEWSWIRE) -- Klotho Neurosciences, Inc. (NASDAQ: KLTO), a cutting-edge biotechnology company focused on developing innovative therapies for neurodegenerative diseases and promoting healthy longevity, is proud to announce that Dr. Robert Langer, co-founder of Moderna, has joined its Scientific Advisory Board. In addition to lending his world-class scientific expertise to guide the company’s strategic direction, this also signals Dr. Langer’s strong belief in the company’s mission and potential. Dr. Langer is a world-renowned scientist, entrepreneur, and biotechnology pioneer. His groundbreaking work in drug delivery systems and tissue engineering has earned him numerous awards and recognition, including the prestigious National Medal of Science and the Charles Stark Draper Prize. As a co-founder of Moderna, Dr. Langer played a pivotal role in revolutionizing the biotech industry with the development of mRNA-based therapeutics, including the COVID-19 vaccine. He is a Professor at the Massachusetts Institute of Technology (MIT) and a faculty member of the Harvard–MIT Program in Health Sciences and Technology. Klotho Neurosciences is working on the development of novel therapies aimed at addressing major unmet medical needs in neurodegenerative disorders, including ALS, Alzheimer’s and Parkinson’s disease. The company’s platform leverages groundbreaking research surrounding the Klotho protein, a powerful anti-aging factor that has shown significant neuroprotective potential in preclinical models. Patents covering the company’s secreted form of Klotho, s-KL, have been issued in the USA, Europe, Hong Kong and China. “We are thrilled to welcome Dr. Langer to our Scientific Advisory Board,” commented Dr. Joseph Sinkule, the Chairman and CEO of Klotho Neurosciences. “His vast experience in translational medicine, biotechnology, and therapeutic innovation will be invaluable as we advance our pipeline and explore new approaches to treating devastating neurodegenerative diseases. I would also like to note that I was privileged to have worked with Bob Langer some years ago when I co-authored a scientific paper with him.” Dr. Langer expressing his enthusiasm for joining Klotho Neurosciences commented, “I am excited to collaborate with the team at Klotho Neurosciences as they explore the therapeutic potential of the Klotho protein in combating neurodegenerative conditions. The company is working on something incredibly promising, and I’m eager to support their efforts.” As a member of the Scientific Advisory Board, Dr. Langer will provide guidance on the scientific and clinical development of the company’s product candidates. Klotho Neurosciences is positioning itself at the forefront of the biotech sector's efforts to address one of the most pressing challenges of modern medicine, which is the treatment of neurodegenerative diseases. Dr. Langer’s involvement represents a significant milestone for the company as it moves forward in its mission to develop life-changing therapies for patients worldwide based on its patented s-KL technology platform. About Klotho Neurosciences, Inc. Klotho Neurosciences, Inc. (NASDAQ: KLTO), a biopharmaceutical company specializing in the development of patented, novel disease-modifying technologies targeting the brain and central nervous system (CNS) that are seen as key developments in treating neurodegenerative and age-related disorders. The Company obtained exclusive worldwide rights to platform technologies and knowhow to develop cutting edge protein, gene and cell therapies to treat age-related pathologies such as ALS, Alzheimer’s and Parkinson’s Disease, multiple sclerosis and rare neurodegenerative diseases. The company’s current portfolio consists of its proprietary gene therapy program using DNA and RNA as therapeutics and diagnostics. Other assets include clinical-stage programs involving antibody biologics targeting cancer and autoimmune diseases, and drug delivery via a needle-free dry powder jet autoinjector called Nanoject. The company is managed by a team of individuals and advisors who are highly experienced in biopharmaceutical product development and commercialization. For more information, contact: Eric Boyd Investor Relations Email: IR@klothoneuro.com Website: www.klothoneuro.com Forward-Looking Statements: This press release contains forward-looking statements. These statements are made under the “safe harbor” provisions of the U.S. Private Securities Litigation Reform Act of 1995. These forward-looking statements generally are identified by the words “believe,” “project,” “expect,” “anticipate,” “estimate,” “intend,” “strategy,” “future,” “opportunity,” “plan,” “may,” “should,” “will,” “would,” “will be,” “will continue,” “will likely result,” and similar expressions. Without limiting the generality of the foregoing, the forward-looking statements in this press release include descriptions of the Company’s future commercial operations. Forward-looking statements are predictions, projections and other statements about future events that are based on current expectations and assumptions and, as a result, are subject to risks and uncertainties. Many factors could cause actual future events to differ materially from the forward-looking statements in this press release, such as the Company’s inability to implement its business plans, identify and realize additional opportunities, or meet or exceed its financial projections and changes in the regulatory or competitive environment in which the Company operates. You should carefully consider the foregoing factors and the other risks and uncertainties described in the documents filed or to be filed by the Company with the U.S. Securities and Exchange Commission (the “SEC”) from time to time, which could cause actual events and results to differ materially from those contained in the forward-looking statements. Copies of these documents are available on the SEC’s website, www.sec.gov. All information provided herein is as of the date of this press release, and the Company undertakes no obligation to update any forward-looking statement, except as required under applicable law.

Strategic Rebranding Reflects Focus on Neurodegenerative Therapies and Healthy LongevityNEW YORK, Sept. 17, 2024 (GLOBE NEWSWIRE) -- The Board of ANEW MEDICAL, INC. (NASDAQ: WENA), today announced a name and ticker symbol change to Klotho Neurosciences, Inc. (NASDAQ: KLTO), and has launched a new website, www.klothoneuro.com. The name and ticker change will have no impact on current shareholders, and there is no action required on their part. The new name embodies the Company's commitment to strategically direct its core investments of time and financial resources toward the multibillion-dollar market opportunities for the company’s patented Klotho gene technology assets in the neurosciences sector. Through its exclusive worldwide license, the company’s patent protected secreted form of the Klotho gene, s-KL, provides Klotho Neurosciences with the opportunity to invest its strategic resources into two distinct major market segments. Innovative Prescription Drugs for Neurodegenerative Diseases The first is the development of new and highly innovative prescription drugs for the treatment of neurodegenerative diseases and age related disorders. From this point forward, Klotho Neurosciences will focus significant attention on the development of its lead candidate, a novel treatment for Amyotrophic Lateral Sclerosis (ALS - also known as Lou Gehrig’s disease), where the company hopes to expeditiously gain FDA approval to enter the clinic. The other key neurological areas of strategic focus for the company are the development of novel therapeutics to treat Alzheimer’s and Parkinson’s disease utilizing the company’s proprietary s-KL gene therapy platform. In these indication areas, and other age-related disorders, the company foresees the potential of entering into research collaborations and partnership agreements with major pharmaceutical companies that are strategically investing in these specific areas. Healthy Longevity The second is the potential to increase healthy longevity or lifespan using the company’s patented s-KL. In pursuit of this, Klotho Neurosciences has entered into an important collaboration with the “Blue Zone” researchers at the Okinawa Research Center for Longevity Science (ORCLS) based in Japan and Hawaii. These researchers have been studying Centenarians and healthy long life spans for many years, and have collected and stored blood samples from these healthy long living individuals. By analyzing these samples, the company anticipates that it will be possible to determine s-KL and Klotho blood and tissue levels in these healthy, long-living persons. Based on preliminary data, the company anticipates that the data will confirm that Klotho protein expression is normalized (not depleted) in these people with long life spans as compared to age-matched control groups. This work will also enable Klotho Neurosciences to validate the clinical assays that are needed for this study which, in the future, may be used to identify persons at high risk for the development of ‘accelerated aging’ and neurologic pathologies. The benefit of this would be that physicians would be able to intercede more promptly in an intervention to provide treatments for these neurologic pathologies prior to persons presenting with advanced disease. Dr. Joseph Sinkule, Chairman, CEO, and Founder commented: “Our new name truly reflects our strategic area of focus going forward. We are excited in particular about the potential of developing novel therapeutics to treat the devastating neurodegenerative disorders such as ALS. Alzheimer’s and Parkinson’s disease, based on our patented secreted form of the Klotho gene, s-KL. The Klotho gene is referred to as the ‘anti-aging gene’ because studies have shown that over-expression of the gene results in improved cognition and a prolonged life span, whereas, conversely, an absence of the gene and gene transcript causes rapid death from age-related pathologies.” Dr. Shalom Hirschman, the company’s Chief Medical Advisor, added: “The data in a severe animal model of human ALS is very compelling. Our plan is to meet with the FDA as soon as possible to discuss the IND and propose a timetable for the potential commencement of clinical trials in ALS patients.” About Klotho Neurosciences, Inc.Klotho Neurosciences, Inc. formerly ANEW MEDICAL, INC., is a Nasdaq-listed pharmaceutical company with the ticker symbol KLTO. The company specializes in the development of patented, novel disease-modifying technologies targeting the brain and central nervous system (CNS) that are seen as key developments in treating neurodegenerative and age-related disorders. The Company obtained exclusive worldwide rights to platform technologies and knowhow to develop cutting edge protein, gene and cell therapies to treat age-related pathologies such as ALS, Alzheimer’s and Parkinson’s disease, multiple sclerosis, and rare neurodegenerative diseases. The company is managed by a team of individuals and advisors that are highly experienced in medical product development and commercialization of medical products. For additional information, please visit www.klothoneuro.com. For more information, contact:Eric Boyd, Investor RelationsEmail: IR@klothoneuro.com Website: www.klothoneuro.com Forward-Looking Statements:This press release contains forward-looking statements. These statements are made under the “safe harbor” provisions of the U.S. Private Securities Litigation Reform Act of 1995. These forward-looking statements generally are identified by the words “believe,” “project,” “expect,” “anticipate,” “estimate,” “intend,” “strategy,” “future,” “opportunity,” “plan,” “may,” “should,” “will,” “would,” “will be,” “will continue,” “will likely result,” and similar expressions. Without limiting the generality of the foregoing, the forward-looking statements in this press release include descriptions of the Company’s future commercial operations. Forward-looking statements are predictions, projections and other statements about future events that are based on current expectations and assumptions and, as a result, are subject to risks and uncertainties. Many factors could cause actual future events to differ materially from the forward-looking statements in this press release, such as the Company’s inability to implement its business plans, identify and realize additional opportunities, or meet or exceed its financial projections and changes in the regulatory or competitive environment in which the Company operates. You should carefully consider the foregoing factors and the other risks and uncertainties described in the documents filed or to be filed by the Company with the U.S. Securities and Exchange Commission (the “SEC”) from time to time, which could cause actual events and results to differ materially from those contained in the forward-looking statements. Copies of these documents are available on the SEC’s website, www.sec.gov. All information provided herein is as of the date of this press release, and the Company undertakes no obligation to update any forward-looking statement, except as required under applicable law.

MIAMI, Sept. 09, 2024 (GLOBE NEWSWIRE) -- ADvantage Therapeutics, Inc., a leading clinical-stage biotechnology company dedicated to the advancement of innovative therapies for Alzheimer's disease, proudly announces the recent appointment of Dr. William A. Haseltine as Strategic Advisor. Dr. Haseltine brings a wealth of experience in biomedical research and biotechnology entrepreneurship that will significantly enhance the company's strategic direction and research initiatives. Dr. Haseltine is renowned for his pioneering contributions to the fields of virology, cancer research, and biotechnology. As the founder of several successful biotech companies, including Human Genome Sciences, Dr. Haseltine has been instrumental in advancing the understanding and treatment of numerous diseases. His extensive background includes significant roles in academia, industry, and public health, where his leadership and expertise have led to groundbreaking discoveries and therapeutic advancements. “We are thrilled to have Dr. Haseltine join our team as a Strategic Advisor,” said Jeffrey Madden, CEO of ADvantage Therapeutics, Inc. “His visionary approach to biomedical research will be invaluable as we advance our pipeline of innovative therapies for Alzheimer’s disease and other age-related diseases. Moreover, Dr. Haseltine's guidance will accelerate our work on Klotho which may represent a new class of therapeutic aimed towards diseases of aging as we seek to develop effective treatments that can make a profound impact on patients' lives.” Dr. Haseltine expressed his enthusiasm for the collaboration, stating, “I am excited to join ADvantage Therapeutics at such a pivotal time in the company’s development. Alzheimer’s disease remains one of the most challenging and complex neurological disorders, and I look forward to working with the talented team at ADvantage Therapeutics to explore new potential therapies including novel therapeutic solutions such as Klotho.” “The anti-aging protein Klotho is unique” says Dr. Carmela Abraham, ADvantage’s Chief Science Officer, who studied Klotho for over 20 years at Boston University School of Medicine and was the first to observe its decline with aging in the Central Nervous System. “Its pleotropic functions are beneficial to several organs and cells, while its absence leads to age-related diseases and early death. Our mRNA therapy will increase the levels of Klotho to those found in young and healthy individuals”. ADvantage Therapeutics, Inc. is at the forefront of developing next-generation therapies aimed at modifying the course of Alzheimer’s disease and other age-related conditions. With a robust pipeline that includes promising candidates in various stages of clinical development, the company is committed to addressing the unmet medical needs of patients through cutting-edge science and innovative treatment approaches, which it believes will ultimately have a significant impact on longevity. About Klotho Klotho, a protein encoded by the KL gene, is renowned for its significant anti-aging properties. Expressed in various cells, particularly in the kidneys and brain, Klotho acts as a circulating protein hormone with numerous health benefits, including neuroprotection, antioxidative effects, and tumor suppression. As Klotho levels naturally decline with age, the risk of age-related diseases such as cognitive decline, chronic kidney disease, and cancer increases. ADvantage Therapeutics is pioneering a novel approach of using mRNA technology to enhance Klotho expression by the body's own cells to produce this vital protein. Their proprietary mRNA sequences have shown promising results, significantly boosting Klotho production and overcoming some of the limitations of protein delivery methods. By enabling sustained Klotho expression and developing innovative delivery systems that can cross the blood-brain barrier, ADvantage Therapeutics is poised to revolutionize anti-aging therapies and potentially extend healthy human lifespan. About AD04™ ADvantage Therapeutics is developing AD04™ as a new class of therapeutic for mild Alzheimer’s disease that exhibits durable multifaceted effects, including both immediate symptomatic relief and long-term disease-modification. The compound has been used extensively as an adjuvant in human and animal vaccination programs. In a previous trial, AD04™ serving as a control against another compound appeared to demonstrate statistically significant slower decline in cognitive and quality of life clinical measures compared to other treatment groups. AD04™ also showed slower decline in hippocampal volume as a biomarker. The Company believes that rather than being limited to a specific aspect of AD pathology, such as amyloid beta or tau, AD04™ may restore expression of genes in lipid metabolism, improve phagocytosis and reduce inflammation. Through multiple mechanisms AD04™ functions as an immunomodulator, stimulating and/or regulating the immune system to reduce AD pathology. About Alzheimer’s Disease About fifty million people worldwide suffer from Alzheimer’s Disease, which is the sixth leading cause of death in industrialized countries. In 2019, the World Health Organization estimated the total worldwide cost of dementia at $1.3 trillion and expects this cost to rise to $2 trillion by 2030. The socio-economic burden of Alzheimer’s Disease is enormous. AD devastates the lives of patients and their families. AD victims lose their memory and independence. Alzheimer’s Disease is a high unmet medical need as there are currently no disease-modifying drugs approved worldwide. The availability of a safe, effective, affordable drug would transform the life of an AD patient from accepting a debilitating disease to the retention of personality, independence, and dignity. About ADvantage Therapeutics, Inc. Headquartered in the Wynwood neighborhood in Miami, ADvantage Therapeutics is developing therapies to treat neurodegenerative conditions with a central focus on Alzheimer’s Disease. The Company’s lead compound AD04™ is a subcutaneous injectable therapy that entered, in November 2023, confirmatory Phase 2b clinical trials in Europe, to evaluate its safety and efficacy in early AD patients. The Company believes that AD04™ may function as an immunomodulator, stimulating and regulating the immune system to reduce AD pathology, rather than limiting therapy to attack the misfolded proteins, beta amyloid and tau. The Company is exploring additional approaches to mitigating neurodegenerative disease, among them increasing the levels of Klotho, a life and health extending protein which will have an overall impact on longevity. About ADvantage Therapeutics GmbH ADvantage Therapeutics GmbH, founded in 2021, is the Vienna BioCenter-based subsidiary of ADvantage Therapeutics, Inc., where the Company conducts early preclinical research and drug development. Safe Harbor-Forward-Looking Statements This press release may contain forward-looking statements, including statements of potential mode of action, potential clinical effect, potential safety, and ADvantage’s potential clinical development program and pipeline program. ADvantage is in the early stages of developing and testing its AD04™ compound and may not receive future regulatory approvals needed for marketing it as a drug. The described clinical effect of our lead compound AD04™ is primarily based on results of a Phase 2 study designed to evaluate a different compound. The described results need to be confirmed for proof of concept, might not be representative of larger scale clinical trials, and do not guarantee future clinical success. Any preclinical results presented here are interim. The mechanism of action of AD04™, as potentially determined in our future investigations, particularly in future clinical trials with patients with Alzheimer’s Disease, might differ from the one presented. For more information, please contact: Jeffrey Madden, CEOADvantage Therapeutics, Inc.195 NW 40th StreetMiami, FL 33127Jeff@advantagetherapeutics.com