α-Klotho

Highly Accomplished Pharmaceutical Leader, Riad El-Dada, Further Enhances Board ExpertiseNEW YORK, Dec. 03, 2024 (GLOBE NEWSWIRE) -- Klotho Neurosciences, Inc. (NASDAQ: KLTO), a U.S.-based biotechnology company pioneering cell and gene therapies for neurodegenerative and age-related disorders, including ALS, Alzheimer’s, and Parkinson’s, today announced the appointment of Riad El-Dada, former US President of Merck, to its Board of Directors. With decades of leadership in the pharmaceutical industry, Mr. El-Dada brings extensive experience in product development, commercialization, and strategic partnerships. During his tenure as US President of Merck, he oversaw commercial teams across a dozen therapeutic areas, managing over $12 billion in revenue. Prior to that role, he served as Managing Director for Merck’s Australian and New Zealand operations. Mr. El-Dada’s career is marked by impactful achievements, including negotiating key development and commercialization deals, as well as building collaborations across all phases of the pharmaceutical lifecycle. Before joining Merck, he advised Fortune 500 clients as a consultant with McKinsey & Company. He has also served on the Healthcare Leadership Council in Washington, DC, where he actively engaged with policymakers on Capitol Hill. Dr. Shalom Hirschman, Chair of the Board’s Nominating Committee, commented: “On behalf of the Board, I am thrilled to welcome Riad El-Dada to Klotho Neurosciences. Riad’s unparalleled expertise in pharmaceutical innovation, strategic leadership, and operational excellence will be invaluable as we advance our mission to develop groundbreaking therapies for neurodegenerative diseases. His proven track record of success positions him as a tremendous asset to Klotho Neurosciences as we accelerate the development of our patent-protected Klotho gene therapy, S-KL, aimed at addressing ALS, Alzheimer’s, and Parkinson’s. We are honored to have him join our Board.” Expressing his enthusiasm, Mr. El-Dada stated: “I am honored to join Klotho Neurosciences’ Board of Directors. The company is developing potentially life-changing therapies using its innovative, patent-protected Klotho anti-aging gene, S-KL. I am eager to contribute to advancing Klotho’s mission, helping realize its vision for transforming the treatment landscape for devastating diseases such as ALS, Alzheimer’s, and Parkinson’s. I look forward to playing my part on the Board where we aim to drive value for our shareholders and, most importantly, bring hope to millions of patients and families worldwide.” About Klotho Neurosciences, Inc. Klotho Neurosciences, Inc. (NASDAQ: KLTO), is a biopharmaceutical company focused on the development of innovative, disease-modifying cell and gene therapies using a protein derived from a patented form of the “anti-aging” human Klotho gene (s-KL), and it’s novel delivery system (s-KL/AAV.myo) to transform and improve the treatment of neurodegenerative and age-related disorders such as ALS, Alzheimer's, and Parkinson's disease. The company’s current portfolio consists of its proprietary cell and gene therapy programs using DNA and RNA as therapeutics and genomics-based diagnostics. Other assets include clinical-stage programs involving antibody biologics targeting cancer and autoimmune diseases, and drug delivery via a needle-free dry powder jet autoinjector called Nanoject. The company is managed by a team of individuals and advisors who are highly experienced in biopharmaceutical product development and commercialization. For more information, contact:Eric BoydInvestor RelationsEmail: IR@klothoneuro.comWebsite: www.klothoneuro.com Forward-Looking Statements: This press release contains forward-looking statements. These statements are made under the “safe harbor” provisions of the U.S. Private Securities Litigation Reform Act of 1995. These forward-looking statements generally are identified by the words “believe,” “project,” “expect,” “anticipate,” “estimate,” “intend,” “strategy,” “future,” “opportunity,” “plan,” “may,” “should,” “will,” “would,” “will be,” “will continue,” “will likely result,” and similar expressions. Without limiting the generality of the foregoing, the forward-looking statements in this press release include descriptions of the Company’s future commercial operations. Forward-looking statements are predictions, projections and other statements about future events that are based on current expectations and assumptions and, as a result, are subject to risks and uncertainties. Many factors could cause actual future events to differ materially from the forward-looking statements in this press release, such as the Company’s inability to implement its business plans, identify and realize additional opportunities, or meet or exceed its financial projections and changes in the regulatory or competitive environment in which the Company operates. You should carefully consider the foregoing factors and the other risks and uncertainties described in the documents filed or to be filed by the Company with the U.S. Securities and Exchange Commission (the “SEC”) from time to time, which could cause actual events and results to differ materially from those contained in the forward-looking statements. Copies of these documents are available on the SEC’s website, www.sec.gov. All information provided herein is as of the date of this press release, and the Company undertakes no obligation to update any forward-looking statement, except as required under applicable law.

Renowned Biotech Leader to Contribute Expertise in Neuroscience and Therapeutics DevelopmentNEW YORK, Sept. 29, 2024 (GLOBE NEWSWIRE) -- Klotho Neurosciences, Inc. (NASDAQ: KLTO), a cutting-edge biotechnology company focused on developing innovative therapies for neurodegenerative diseases and promoting healthy longevity, is proud to announce that Dr. Robert Langer, co-founder of Moderna, has joined its Scientific Advisory Board. In addition to lending his world-class scientific expertise to guide the company’s strategic direction, this also signals Dr. Langer’s strong belief in the company’s mission and potential. Dr. Langer is a world-renowned scientist, entrepreneur, and biotechnology pioneer. His groundbreaking work in drug delivery systems and tissue engineering has earned him numerous awards and recognition, including the prestigious National Medal of Science and the Charles Stark Draper Prize. As a co-founder of Moderna, Dr. Langer played a pivotal role in revolutionizing the biotech industry with the development of mRNA-based therapeutics, including the COVID-19 vaccine. He is a Professor at the Massachusetts Institute of Technology (MIT) and a faculty member of the Harvard–MIT Program in Health Sciences and Technology. Klotho Neurosciences is working on the development of novel therapies aimed at addressing major unmet medical needs in neurodegenerative disorders, including ALS, Alzheimer’s and Parkinson’s disease. The company’s platform leverages groundbreaking research surrounding the Klotho protein, a powerful anti-aging factor that has shown significant neuroprotective potential in preclinical models. Patents covering the company’s secreted form of Klotho, s-KL, have been issued in the USA, Europe, Hong Kong and China. “We are thrilled to welcome Dr. Langer to our Scientific Advisory Board,” commented Dr. Joseph Sinkule, the Chairman and CEO of Klotho Neurosciences. “His vast experience in translational medicine, biotechnology, and therapeutic innovation will be invaluable as we advance our pipeline and explore new approaches to treating devastating neurodegenerative diseases. I would also like to note that I was privileged to have worked with Bob Langer some years ago when I co-authored a scientific paper with him.” Dr. Langer expressing his enthusiasm for joining Klotho Neurosciences commented, “I am excited to collaborate with the team at Klotho Neurosciences as they explore the therapeutic potential of the Klotho protein in combating neurodegenerative conditions. The company is working on something incredibly promising, and I’m eager to support their efforts.” As a member of the Scientific Advisory Board, Dr. Langer will provide guidance on the scientific and clinical development of the company’s product candidates. Klotho Neurosciences is positioning itself at the forefront of the biotech sector's efforts to address one of the most pressing challenges of modern medicine, which is the treatment of neurodegenerative diseases. Dr. Langer’s involvement represents a significant milestone for the company as it moves forward in its mission to develop life-changing therapies for patients worldwide based on its patented s-KL technology platform. About Klotho Neurosciences, Inc. Klotho Neurosciences, Inc. (NASDAQ: KLTO), a biopharmaceutical company specializing in the development of patented, novel disease-modifying technologies targeting the brain and central nervous system (CNS) that are seen as key developments in treating neurodegenerative and age-related disorders. The Company obtained exclusive worldwide rights to platform technologies and knowhow to develop cutting edge protein, gene and cell therapies to treat age-related pathologies such as ALS, Alzheimer’s and Parkinson’s Disease, multiple sclerosis and rare neurodegenerative diseases. The company’s current portfolio consists of its proprietary gene therapy program using DNA and RNA as therapeutics and diagnostics. Other assets include clinical-stage programs involving antibody biologics targeting cancer and autoimmune diseases, and drug delivery via a needle-free dry powder jet autoinjector called Nanoject. The company is managed by a team of individuals and advisors who are highly experienced in biopharmaceutical product development and commercialization. For more information, contact: Eric Boyd Investor Relations Email: IR@klothoneuro.com Website: www.klothoneuro.com Forward-Looking Statements: This press release contains forward-looking statements. These statements are made under the “safe harbor” provisions of the U.S. Private Securities Litigation Reform Act of 1995. These forward-looking statements generally are identified by the words “believe,” “project,” “expect,” “anticipate,” “estimate,” “intend,” “strategy,” “future,” “opportunity,” “plan,” “may,” “should,” “will,” “would,” “will be,” “will continue,” “will likely result,” and similar expressions. Without limiting the generality of the foregoing, the forward-looking statements in this press release include descriptions of the Company’s future commercial operations. Forward-looking statements are predictions, projections and other statements about future events that are based on current expectations and assumptions and, as a result, are subject to risks and uncertainties. Many factors could cause actual future events to differ materially from the forward-looking statements in this press release, such as the Company’s inability to implement its business plans, identify and realize additional opportunities, or meet or exceed its financial projections and changes in the regulatory or competitive environment in which the Company operates. You should carefully consider the foregoing factors and the other risks and uncertainties described in the documents filed or to be filed by the Company with the U.S. Securities and Exchange Commission (the “SEC”) from time to time, which could cause actual events and results to differ materially from those contained in the forward-looking statements. Copies of these documents are available on the SEC’s website, www.sec.gov. All information provided herein is as of the date of this press release, and the Company undertakes no obligation to update any forward-looking statement, except as required under applicable law.

Strategic Rebranding Reflects Focus on Neurodegenerative Therapies and Healthy LongevityNEW YORK, Sept. 17, 2024 (GLOBE NEWSWIRE) -- The Board of ANEW MEDICAL, INC. (NASDAQ: WENA), today announced a name and ticker symbol change to Klotho Neurosciences, Inc. (NASDAQ: KLTO), and has launched a new website, www.klothoneuro.com. The name and ticker change will have no impact on current shareholders, and there is no action required on their part. The new name embodies the Company's commitment to strategically direct its core investments of time and financial resources toward the multibillion-dollar market opportunities for the company’s patented Klotho gene technology assets in the neurosciences sector. Through its exclusive worldwide license, the company’s patent protected secreted form of the Klotho gene, s-KL, provides Klotho Neurosciences with the opportunity to invest its strategic resources into two distinct major market segments. Innovative Prescription Drugs for Neurodegenerative Diseases The first is the development of new and highly innovative prescription drugs for the treatment of neurodegenerative diseases and age related disorders. From this point forward, Klotho Neurosciences will focus significant attention on the development of its lead candidate, a novel treatment for Amyotrophic Lateral Sclerosis (ALS - also known as Lou Gehrig’s disease), where the company hopes to expeditiously gain FDA approval to enter the clinic. The other key neurological areas of strategic focus for the company are the development of novel therapeutics to treat Alzheimer’s and Parkinson’s disease utilizing the company’s proprietary s-KL gene therapy platform. In these indication areas, and other age-related disorders, the company foresees the potential of entering into research collaborations and partnership agreements with major pharmaceutical companies that are strategically investing in these specific areas. Healthy Longevity The second is the potential to increase healthy longevity or lifespan using the company’s patented s-KL. In pursuit of this, Klotho Neurosciences has entered into an important collaboration with the “Blue Zone” researchers at the Okinawa Research Center for Longevity Science (ORCLS) based in Japan and Hawaii. These researchers have been studying Centenarians and healthy long life spans for many years, and have collected and stored blood samples from these healthy long living individuals. By analyzing these samples, the company anticipates that it will be possible to determine s-KL and Klotho blood and tissue levels in these healthy, long-living persons. Based on preliminary data, the company anticipates that the data will confirm that Klotho protein expression is normalized (not depleted) in these people with long life spans as compared to age-matched control groups. This work will also enable Klotho Neurosciences to validate the clinical assays that are needed for this study which, in the future, may be used to identify persons at high risk for the development of ‘accelerated aging’ and neurologic pathologies. The benefit of this would be that physicians would be able to intercede more promptly in an intervention to provide treatments for these neurologic pathologies prior to persons presenting with advanced disease. Dr. Joseph Sinkule, Chairman, CEO, and Founder commented: “Our new name truly reflects our strategic area of focus going forward. We are excited in particular about the potential of developing novel therapeutics to treat the devastating neurodegenerative disorders such as ALS. Alzheimer’s and Parkinson’s disease, based on our patented secreted form of the Klotho gene, s-KL. The Klotho gene is referred to as the ‘anti-aging gene’ because studies have shown that over-expression of the gene results in improved cognition and a prolonged life span, whereas, conversely, an absence of the gene and gene transcript causes rapid death from age-related pathologies.” Dr. Shalom Hirschman, the company’s Chief Medical Advisor, added: “The data in a severe animal model of human ALS is very compelling. Our plan is to meet with the FDA as soon as possible to discuss the IND and propose a timetable for the potential commencement of clinical trials in ALS patients.” About Klotho Neurosciences, Inc.Klotho Neurosciences, Inc. formerly ANEW MEDICAL, INC., is a Nasdaq-listed pharmaceutical company with the ticker symbol KLTO. The company specializes in the development of patented, novel disease-modifying technologies targeting the brain and central nervous system (CNS) that are seen as key developments in treating neurodegenerative and age-related disorders. The Company obtained exclusive worldwide rights to platform technologies and knowhow to develop cutting edge protein, gene and cell therapies to treat age-related pathologies such as ALS, Alzheimer’s and Parkinson’s disease, multiple sclerosis, and rare neurodegenerative diseases. The company is managed by a team of individuals and advisors that are highly experienced in medical product development and commercialization of medical products. For additional information, please visit www.klothoneuro.com. For more information, contact:Eric Boyd, Investor RelationsEmail: IR@klothoneuro.com Website: www.klothoneuro.com Forward-Looking Statements:This press release contains forward-looking statements. These statements are made under the “safe harbor” provisions of the U.S. Private Securities Litigation Reform Act of 1995. These forward-looking statements generally are identified by the words “believe,” “project,” “expect,” “anticipate,” “estimate,” “intend,” “strategy,” “future,” “opportunity,” “plan,” “may,” “should,” “will,” “would,” “will be,” “will continue,” “will likely result,” and similar expressions. Without limiting the generality of the foregoing, the forward-looking statements in this press release include descriptions of the Company’s future commercial operations. Forward-looking statements are predictions, projections and other statements about future events that are based on current expectations and assumptions and, as a result, are subject to risks and uncertainties. Many factors could cause actual future events to differ materially from the forward-looking statements in this press release, such as the Company’s inability to implement its business plans, identify and realize additional opportunities, or meet or exceed its financial projections and changes in the regulatory or competitive environment in which the Company operates. You should carefully consider the foregoing factors and the other risks and uncertainties described in the documents filed or to be filed by the Company with the U.S. Securities and Exchange Commission (the “SEC”) from time to time, which could cause actual events and results to differ materially from those contained in the forward-looking statements. Copies of these documents are available on the SEC’s website, www.sec.gov. All information provided herein is as of the date of this press release, and the Company undertakes no obligation to update any forward-looking statement, except as required under applicable law.