Synonyms 组织蛋白酶K, Cathepsin K, cathepsin K (pycnodysostosis) + [8] |
Introduction Thiol protease involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation. Involved in the release of thyroid hormone thyroxine (T4) by limited proteolysis of TG/thyroglobulin in the thyroid follicle lumen (PubMed:11082042). |
Mechanism CD11b antagonists [+3] |
Active Org. |
Originator Org. |
Active Indication |
Inactive Indication- |
Drug Highest PhasePreclinical |
First Approval Ctry. / Loc.- |
First Approval Date20 Jan 1800 |
Target |
Mechanism CTSK inhibitors |
Active Org. |
Originator Org. |
Active Indication |
Inactive Indication- |
Drug Highest PhasePreclinical |
First Approval Ctry. / Loc.- |
First Approval Date20 Jan 1800 |
Mechanism CAPN1 inhibitors [+3] |
Active Org. |
Originator Org. |
Active Indication |
Inactive Indication- |
Drug Highest PhasePreclinical |
First Approval Ctry. / Loc.- |
First Approval Date20 Jan 1800 |
Start Date13 Sep 2022 |
Sponsor / Collaborator Aristea Therapeutics, Inc.Startup |
Start Date18 Jul 2022 |
Sponsor / Collaborator Aristea Therapeutics, Inc.Startup |
Start Date27 Apr 2022 |
Sponsor / Collaborator Aristea Therapeutics, Inc.Startup |