Last update 01 Nov 2024

CDS1

Last update 01 Nov 2024

Basic Info

Synonyms

CDP-DAG synthase 1, CDP-DG synthase 1, CDP-diacylglycerol synthase 1

+ [7]

Introduction

Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol (PubMed:9407135, PubMed:25375833). Exhibits almost no acyl chain preference for PA, showing no discrimination for the sn-1/sn-2 acyl chain composition of PAs (PubMed:25375833). Plays an important role in regulating the growth of lipid droplets which are storage organelles at the center of lipid and energy homeostasis (PubMed:26946540, PubMed:31548309). Positively regulates the differentiation and development of adipocytes (By similarity).

Drugs associated with CDS1

CN116801889

Patent Mining

Target

CDS1

Mechanism-

Active Org.

Memorial Sloan Kettering Cancer Center

Originator Org.

Memorial Sloan Kettering Cancer Center

Active Indication

Neoplasms

Inactive Indication-

Drug Highest PhaseDiscovery

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

CP-380867

Target

CDS1

Mechanism

CDS1 inhibitors

Active Org.-

Originator Org.

Pfizer Inc.

Active Indication-

Inactive Indication

Diabetes Complications [+1]

Drug Highest PhasePending

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

100 Clinical Results associated with CDS1

100 Translational Medicine associated with CDS1

0 Patents (Medical) associated with CDS1

2,087

Literatures (Medical) associated with CDS1

01 Feb 2025·Journal of Colloid and Interface Science

Ultrahigh-performance photodetectors based on low-dimensional Cs2AgBiBr6/CdS heterojunction

Article

Author: Liu, Yingkai ; Yang, Peizhi ; Wang, Qianjin ; Ding, Jun ; Liu, Aimin ; Tan, Qiuhong

Lead-free double perovskite Cs₂AgBiBr₆ has garnered increasing attention in photoelectric applications owing to its good stability and excellent photoelectric properties. However, the poor carrier transport in Cs₂AgBiBr₆ thin films constraints their further application in photodetection. To overcome this issue, we have developed an innovative low-dimensional Cs₂AgBiBr₆/CdS heterojunction photodetector with substantially improved performance. The device achieved a high responsivity of 6.66 × 10³ A/W, an outstanding specific detectivity of 2.10 × 10¹⁴ Jones, and an impressive external quantum efficiency of 1.88 × 10⁶ %. Additionally, the on/off current ratio of the heterojunction device reached an impressive 6.18 × 10⁷. These key parameters are significantly better than those of most previously reported Cs₂AgBiBr₆-based photodetectors. Furthermore, scanning photocurrent mapping and band arrangement analysis were performed to elucidate the mechanism of photocurrent generation and transport in the low-dimensional Cs₂AgBiBr₆/CdS heterojunction photodetectors. This study highlights the outstanding performance of Cs₂AgBiBr₆/CdS heterojunction and provides a simple and effective strategy for developing high-performance Cs₂AgBiBr₆-based photodetectors.

01 Jan 2025·Journal of Colloid and Interface Science

Reinforcing Cd-S bonds through morphology engineering for enhanced intrinsic photocatalytic stability of CdS

Article

Author: Mao, Chang-Jie ; Jiang, Yong ; Wu, Enci ; Chen, Jingshuai ; Zhang, Jun ; Bai, Jia-Qi ; Qian, Baohao ; Cai, Mengdie ; Sun, Song

Effectively mitigating photocorrosion is paramount for achieving high-efficiency and sustainable hydrogen production through photocatalytic water splitting over CdS. In this work, we develop a morphology engineering strategy with adjustable Cd-S bond energy through a simple chemical bath deposition method to synthesize novel hollow hemispherical CdS (H-CdS). The morphologic structure CdS can be precisely controlled by adjusting the reaction temperature, time and pH. Compared with common morphologies of CdS, H-CdS, with its reinforced Cd-S bonding, exhibits not only improved photocatalytic hydrogen evolution activity (20.04 mmol/g/h) but also exceptional resistance to photocorrosion, resulting in outstanding cyclic stability even without the aid of cocatalysts or the introduction of other semiconductors. Comprehensive characterizations reveal that the photocorrosion resistance of H-CdS stems from the high Cd-S bond strength. Moreover, in-situ infrared spectroscopy confirms alterations in the properties and activities of the various CdS morphologies after photocatalytic reaction due to photocorrosion. We thoroughly describe the relationship among morphology, surface energy, bond energy and photocorrosion resistance. Our findings present a novel strategy for mitigating the photocorrosion of CdS and offer valuable insights for future research on CdS photocatalysts aimed at stable water splitting.

01 Jan 2025·Journal of Colloid and Interface Science

Construction of a hollow heterojunction interface to accelerate the photocatalytic cleavage of lignin Cβ-O bonds

Article

Author: Niu, Yanan ; Yang, Shuai ; Li, Jianmin ; Wang, Jide ; Cao, Xianglei ; Guo, Changyan

Photocatalytic splitting of the C_β-O bond is regarded as a prospective strategy for transforming lignin, and it is imperative to develop novel photocatalysts with effective photogenerated charges separation and solar absorption capacity. Herein, a novel hollow ZIF-8/CdS heterostructure photocatalyst was synthesized for the catalytic splitting of lignin C_β-O bonds. The photocatalytic cleavage rate of C_β-O bond of ligin β-O-4 reached 30.3∙mmol∙h^-1∙g^-1 within 20 min under visible light exposure. It is noteworthy that the utilization of intricate natural lignin molecules in this photocatalytic system has yielded successful depolymerization. The DFT and XPS results indicate a potential unidirectional electron migration from ZIF-8 to CdS in ZIF-8/CdS composites transfer. This electron transport path follows the direct Z-scheme heterostructure mechanism, resulting in the generation of an internal electric field between ZIF-8 and CdS. Impressively, the synergistic combination of the hollow structure and Z-scheme heterostructure effectively enhances the efficiency of charge carrier separation and maintains a robust redox potential, thereby facilitating C_α-radical generation. This study proposes a novel photocatalyst design strategy that integrates hollow structures and Z-scheme heterojunctions, with the aim of targeting the depolymerization of the C_β-O bond in lignin.

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CDS1

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