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Last update 08 May 2025

CDS1

Last update 08 May 2025

Basic Info

Synonyms

CDP-DAG synthase 1, CDP-DG synthase 1, CDP-diacylglycerol synthase 1

+ [7]

Introduction

Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol (PubMed:25375833, PubMed:9407135). Exhibits almost no acyl chain preference for PA, showing no discrimination for the sn-1/sn-2 acyl chain composition of PAs (PubMed:25375833). Plays an important role in regulating the growth of lipid droplets which are storage organelles at the center of lipid and energy homeostasis (PubMed:26946540, PubMed:31548309). Positively regulates the differentiation and development of adipocytes (By similarity).

Drugs associated with CDS1

CN119875630

Patent Mining

Target

CDS1

Mechanism

CDS1 inhibitors

Active Org.

Shanxi Medical University

Originator Org.

Shanxi Medical University

Active Indication

Hemolysis [+1]

Inactive Indication-

Drug Highest PhaseDiscovery

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

CP-380867

Target

CDS1

Mechanism

CDS1 inhibitors

Active Org.-

Originator Org.

Pfizer Inc.

Active Indication-

Inactive Indication

Diabetes Complications [+1]

Drug Highest PhasePending

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

100 Clinical Results associated with CDS1

100 Translational Medicine associated with CDS1

0 Patents (Medical) associated with CDS1

2,040

Literatures (Medical) associated with CDS1

31 Dec 2025·Plant Signaling & Behavior

CDP-DAG synthases regulate plant growth and broad-spectrum disease resistance

Article

Author: Yang, Lei ; Du, Xin Qiao ; Xue, Hongwei ; Luo, Jie ; Li, Qiang ; Yang, Wei ; Tan, Ronglei ; Sha, Gan ; Gong, Qiuwen ; Li, Guotian ; Li, Yufei ; Cheng, Jiasen ; Liu, Xiaofan

Phosphatidic acid (PA) functions as a cell membrane component and signaling molecule in plants. PA metabolism has multiple routes, in one of which PA is converted into cytidine diphosphate diacylglycerol (CDP-DAG) by CDP-DAG synthases (CDSs). CDS genes are highly conserved in plants. Here, we found that knock-down of the CDS gene enhanced the resistance of Arabidopsis thaliana to multiple pathogens, with a growth penalty. When Arabidopsis leaves were treated with chitin or flg22, reactive oxygen species (ROS) production in cds mutants was significantly higher than that in the wild-type (WT). Similarly, phosphorylation of mitogen-activated protein kinases (MAPKs) in the cds1cds2 double mutant was significantly increased compared to the WT. By integrating lipidomics, transcriptomics, and metabolomics data, PA accumulation was observed in mutants cds1cds2, activating the jasmonic acid (JA) and salicylic acid (SA) signaling pathway, and increasing transcript levels of plant defense-related genes. Significant accumulation of the downstream metabolites including serotonin and 5-methoxyindole was also found, which plays important roles in plant immunity. In conclusion, our study indicated the role of CDSs in broad-spectrum disease resistance in Arabidopsis and that CDSs are involved in plant metabolic regulation.

01 Aug 2025·Journal of Colloid and Interface Science

Incorporation of ultrafine TiO2/CdS heterojunction in dendritic porphyrins mesoporous silica nanospheres for efficient photocatalytic oxidation of styrene

Article

Author: Wang, Runwei ; Qiao, Xiaoyun ; Qiu, Shilun ; Xiong, Zeshan ; Zhang, Zongtao ; Zhang, Huibin ; Zhang, Tingsong

In this paper, a novel host-guest assembly strategy is developed to incorporate TiO₂ nanoparticles and CdS quantum dots (CdS QDs) into the photoactive dendritic porphyrins mesoporous silica nanospheres (DPMSN) channels for establishing heterojunctions nanoreactors (designated as DPMSTNC). The well-defined dendritic architecture facilitates the high dispersion of TiO₂/CdS heterojunctions within the DPMSN matrix, effectively maximizing the interfacial contact area between the heterojunction components and the cobalt porphyrin framework. Crucially, the synergistic interplay of cobalt porphyrins incorporated in the silica framework and the ultra-small TiO₂/CdS heterojunction in the dendritic channels promotes efficient charge transfer and separation in the nanoreactor. The optimized DPMSTNC nanoreactor exhibits excellent catalytic performance with a conversion of 96.0 % and a selectivity of 92.0 % in styrene oxidation, which significantly surpasses that of single-component catalysts and simple composite heterostructure catalysts. This nanoreactor design strategy, which combines spatially confined heterojunctions with photoactive porous frameworks, provides a novel and versatile platform for developing high-efficiency photocatalytic systems through precise nanoarchitectural control.

01 Jul 2025·Journal of Colloid and Interface Science

One-pot synthesis of transition-metal-sulfides decorated CdS by low-temperature KSCN flux: An effective route to strengthen the interface for enhanced photocatalytic H2 evolution

Article

Author: You, Aichun ; Fu, Xianliang ; Zhao, Xuan ; Yang, Lei ; Xu, Man ; Shen, Jinni ; Fan, Yuge ; Zhu, Li

The performance of decorated photocatalysts is highly dependent on the interfacial contact between the cocatalyst and the substrate photocatalyst, which is essentially determined by their fabrication routes. Herein, a simple one-pot preparation method based on low-temperature KSCN flux was developed for the synthesis of sulfide photocatalysts with MS/CdS (MS = CoS₂, NiS₂, Cu_1.8S, SnS₂, MoS₂, and WS₂) as prototypes. The results indicate that a sulfidation of Cd²⁺ and the cocatalyst precursors can be achieved successively in the reaction system, which facilitates the formation of a welded interface as the cocatalysts can grow epitaxially on the formed CdS surface. The KSCN flux serves not only as a reaction medium but also as S^2- precursor. Most of the MS (except for WS₂) could be successfully fabricated and deposited in situ on CdS. However, only the transition-metal-sulfides (TMSs, MoS₂, CoS₂, and NiS₂) decorated samples showed enhanced photocatalytic H₂ evolution reaction (HER) performance and the activities decreased in the order of MoS₂ > CoS₂ > NiS₂. The sample loaded with 1 %MoS₂ demonstrated the highest activity, which was 25 times higher than that of the pristine CdS. The superior HER performance could be ascribed to the loading of the active MoS₂ sites for HER and the intimate tandem type I (between CdS and 2H-MoS₂) and Schottky (between 2H- and 1T-MoS₂) junctions for separation of photoinduced charge carriers. Compared to the conventional preparation methods, the developed one-pot flux route demonstrates remarkable advantages in fabricating highly efficient MoS₂/CdS photocatalyst besides its convenience, versatility, and scalability. We believe that, in addition to CdS, the developed route can also be applied to synthesize other sulfide-based photocatalysts.

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CDS1

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