Last update 01 Nov 2024

TOP2A

Basic Info

Synonyms
DNA topoisomerase 2-alpha, DNA topoisomerase II alpha, DNA topoisomerase II, alpha isozyme
+ [5]
Introduction
Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand (PubMed:17567603, PubMed:18790802, PubMed:22013166, PubMed:22323612). May play a role in regulating the period length of BMAL1 transcriptional oscillation (By similarity).

Analysis

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