LHCGR x ER

Last update 08 May 2025

Basic Info

Related Targets

LHCGRER

Drugs associated with LHCGR x ER

Decapeptide GnRH-II receptor antagonists/Estrogen receptor down regulators(University of Gottingen/MBM Science Bridge)

Target

ER x LHCGR

Mechanism

ERs antagonists [+1]

Active Org.-

Originator Org.

University of Gottingen

Active Indication-

Inactive Indication

Neoplasms

Drug Highest PhasePending

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

100 Clinical Results associated with LHCGR x ER

100 Translational Medicine associated with LHCGR x ER

0 Patents (Medical) associated with LHCGR x ER

Literatures (Medical) associated with LHCGR x ER

01 Feb 2025·Fish Physiology and Biochemistry

Reproduction in yellow drum (Nibea albiflora): insights from endocrine regulation and intestinal microbiota changes during reproductive season

Article

Author: Li, Haidong ; Ye, Huan ; Hu, Weihua ; Su, Kangjia ; Chen, Ruiyi ; Xu, Dongdong

The yellow drum (Nibea albiflora), a pivotal species within the Sciaenidae family, is economically important in the mariculture along the coastal regions of China. A comprehensive understanding gonadal maturation and spawning processes is crucial for seed production in the artificial propagation of yellow drum. This study investigates serum hormonal fluctuations, gonadal histological features, sex hormone receptor gene expression, and intestinal microbiota composition in both male and female yellow drum during the reproductive season. Twenty individuals were sampled from reproductive stages IV, V, and VI, respectively. During the spawning season, no significant differences were observed in the levels of PROG, E2, and 11-KT across different stages, in both males and females, with no significant sex-based differences. Subsequent analysis indicated a significant upregulation of fshr, lhcgr, and esr expression in the ovary during spawning stages. In contrast, within the testis, the expression levels of fshr, ar, and esr remained relatively constant across different stages, whereas lhcgr expression was markedly higher during the spawning stages compared with prespawning and post-spawning stages. Analysis of intestinal microbiota revealed a predominance of Bacteroidota, Firmicutes, and Proteobacteria, with no significant sex differences. At the class level, the abundances of Alphaproteobacteria, Gammaproteobacteria, and Bacilli exhibited significant fluctuations during the spawning and post-spawning stages in both sexes. At the genus level, g_Muribaculaceae and g_Bacteroides were abundant during spawning stages in both sexes. A Mantel test showed significant positive correlations between PROG levels and the abundances of g_Bacteroides in males. In females, PROG levels were positively correlated with the abundance of g_Prevotella. These findings enhance our understanding of the interplay between reproductive biology and the biological functions of intestinal microbiota in yellow drum broodstock during the reproductive season, thereby laying a foundation for the development of artificial propagation technology in this species.

01 Feb 2025·Journal of Environmental Management

Maternal exposure to chronic, low-dose nonylphenol in zebrafish: Disruption of ovarian health, reproductive function, and embryogenesis

Article

Author: Samanta, Anwesha ; Banerjee, Sambuddha ; Biswas, Subhasri ; Dam, Bomba ; Maitra, Sudipta ; Ghosh, Sandip

Nonylphenol (NP), a non-ionic surfactant and potent endocrine disruptor, is known for its environmental persistence, biotic accumulation potential and toxicity. Nonetheless, mechanisms underlying NP modulation of female fertility with potential impact on embryogenesis in the unexposed offspring remain elusive. This study investigates the effects and toxic mechanisms of maternal exposure to NP at varying concentrations (50 and 100 μg/L) on zebrafish (Danio rerio), specifically focusing on ovarian health, reproductive parameters, and early developmental potential in the F1 generation. Our findings indicate a higher accumulation of NP in the ovaries compared to muscle tissue. Further, chronic (28 days) NP exposure promotes ovarian reactive oxygen species (ROS) accumulation, activates the MAPK (JNK, p38 MAPK, ERK1/2) pathways, AP-1 induction, and elevated expression of pro-inflammatory cytokines (Tnf-α, Il-1β, Il-6) triggering inflammation. Besides, heightened follicular atresia in NP-treated ovaries relates to increased Bax/Bcl2 ratio, cleaved caspase 3 and Parp1 activation prompting apoptosis. While it showed higher affinity to zebrafish ERα (in silico analysis), NP exposure in vivo promotes a robust increase in ovarian ERα but abrogated ERβ expression and a significant alteration in fshr and lhcgr transcripts. While attenuated StAR and P450 aromatase expression at both mRNA and protein levels and reduced igf3 expression reveal impaired ovarian microenvironment, NP-induced dysregulated NO/NOS/cyclooxygenase signaling and attenuation of hCG-induced p34cdc2 activation and oocyte maturation correspond well with decreased fecundity and fertilization efficiency. Intriguingly, maternal exposure to NP resulted in delayed embryogenesis, developmental aberrations, and reduced hatching rates in the unexposed offspring, risking F1 generation. Collectively, this study provides mechanistic insights into the detrimental influence of maternal exposure to NP on ovarian dysfunction, reproductive insufficiency and embryotoxicity.

01 Jan 2025·Poultry Science

Evaluating ovarian follicles and their steroid hormone gene expression patterns in a high egg-producing research turkey line

Article

Author: Hall, George B ; Long, Julie A ; Diehl, Kristen ; Hildenberger, Diane

Low egg-producing turkeys reduce the profitability of a flock by limiting the number of poults that can be hatched. Understanding the biological mechanics behind egg-production rates will greatly benefit the industry. Two lines with vastly different egg production rates are the Ohio State University E line, and its unselected counterpart, the random-bred control one (RBC1). Differences between E Line and RBC1 hens (n = 4 per line) were investigated by measuring egg production traits, ovarian and follicle anatomical characteristics, and gene expression for reproductively important genes within different follicle types. Data were analyzed by an ANOVA mixed model procedure in SAS. The E line hens produced 20% more eggs than the RBC1 hens, even though they had similar numbers of preovulatory follicles in their ovaries. This was accomplished by increasing clutch length and keeping the pause length the same. On the gene expression side small white follicles (SWF) within E line hens had less LHCGR expression which coincided with downregulation of CYP11A1 and CYP17A1. Along with an upregulation of PRLR in small yellow follicles (SYF) which also coincided with downregulation of CYP17A1. In both cases changes in pituitary hormone receptor transcription levels appeared to affect the steroid hormone synthesis pathway. In SWF from E line hens ESR2 was downregulated, however in the large white follicles and selected follicles ESR1 was the estradiol receptor which was downregulated. The similarity in preovulatory numbers suggests that E line hens aren't selecting more follicles to grow, but instead, follicles are growing faster. Based on the gene expression patterns, the reduction of steroid hormone synthesis might hint at the follicles putting more energy into growth and differentiation. At the same time, the decrease in estradiol receptor might limit the negative effects of estradiol on granulosa cells and allow for more rapid growth, suggesting a possible mechanism for the higher egg production trait of the E line.

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