Last update 01 Nov 2024

α1B-AR

Last update 01 Nov 2024

Basic Info

Synonyms

ADRA1B, adrenergic, alpha-1B-, receptor, adrenoceptor alpha 1B

+ [3]

Introduction

This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes.

Drugs associated with α1B-AR

Lisdexamfetamine Dimesylate

Target

DAT x α1B-AR

Mechanism

DAT antagonists [+1]

Active Org.

Takeda Pharmaceutical Co., Ltd. [+3]

Originator Org.

New River Pharmaceuticals, Inc.

Active Indication

Binge-Eating Disorder [+2]

Inactive Indication

Amphetamine-Related Disorders [+11]

Drug Highest PhaseApproved

First Approval Ctry. / Loc.

First Approval Date23 Feb 2007

Norepinephrine Bitartrate

Target

α1A-AR x α1B-AR

Mechanism

α1A-AR agonists [+1]

Active Org.

Hospira, Inc. [+7]

Originator Org.

Hospira, Inc.

Active Indication

Shock [+7]

Inactive Indication-

Drug Highest PhaseApproved

First Approval Ctry. / Loc.

First Approval Date13 Jul 1950

Thioproperazine

Target

D1 receptor x D2 receptor x α1A-AR x α1B-AR

Mechanism

D1 receptor antagonists [+3]

Active Org.-

Originator Org.-

Active Indication-

Inactive Indication-

Drug Highest PhaseApproved

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

505

Clinical Trials associated with α1B-AR

NCT06158035 / Not yet recruitingNot ApplicableIIT

ED90 of Norepinephrine and Phenylephrine Boluses for Treating Postspinal Anesthesia Hypotension Under Intensive Treatment in Preeclamptic Patients During Cesarean Section

The objective of this study is to investigate the ED90 of norepinephrine and phenylephrine boluses for treating postspinal anesthesia hypotension under intensive treatment in preeclamptic patients during cesarean section

Start Date01 Jul 2025

Sponsor / Collaborator

General Hospital of Ningxia Medical University

NCT06158009 / Not yet recruitingNot ApplicableIIT

ED90 of Norepinephrine and Phenylephrine Boluses for Treating Postspinal Anesthesia Hypotension Under Intensive Treatment During Cesarean Section

The objective of this study is to investigate the ED90 of norepinephrine and phenylephrine boluses for treating postspinal anesthesia hypotension under intensive treatment during cesarean section

Start Date01 Apr 2025

Sponsor / Collaborator

General Hospital of Ningxia Medical University

NCT06508359 / Not yet recruitingNot ApplicableIIT

Prophylactic vs Rescue Norepinephrine and Phenylephrine for Spinal Anesthesia-induced Hypotension on Neonatal Outcomes During Cesarean Section: A Multicenter, Single-blind, Crossover, Factorial Cluster Trial

This study aims to explore the effects of different application modes (prophylactic and rescue strategy) of norepinephrine and norepinephrine on neonate umbilical artery pH undergoing cesarean section.

Start Date01 Mar 2025

Sponsor / Collaborator

General Hospital of Ningxia Medical University

100 Clinical Results associated with α1B-AR

100 Translational Medicine associated with α1B-AR

0 Patents (Medical) associated with α1B-AR

850

Literatures (Medical) associated with α1B-AR

01 Nov 2024·American Journal of Physiology-Endocrinology and Metabolism

Liver adrenoceptor alpha-1b plays a key role in energy and glucose homeostasis in female mice

Article

Author: Elmquist, Joel K. ; Mouchiroud, Mathilde ; Beji, Sarra ; Silva, Anisia ; Lavoie, Olivier ; Caron, Alexandre

The sympathetic nervous system plays an important role in regulating hepatic physiology and metabolism. However, the identity of the adrenoceptors involved in these effects is still elusive. Using CRISPR-Cas9, we developed a novel transgenic tool to study the role of liver α-1b adrenoceptor (ADRA1B). We show that ADRA1B plays a key role in mediating the effects of the sympathetic nervous system on hepatic metabolism, particularly in female mice.

01 Oct 2024·Neuropsychopharmacology

Smoking-informed methylation and expression QTLs in human brain and colocalization with smoking-associated genetic loci

Article

Author: Marks, Jesse A ; Page, Grier P ; Han, Shizhong ; Bierut, Laura J ; Won, Hyejung ; Zhou, Linran ; Hyde, Thomas M ; Mandal, Meisha ; Quach, Bryan C ; Carnes, Megan Ulmer ; Jaffe, Andrew E ; Kleinman, Joel E ; Maher, Brion S ; Hancock, Dana B ; Deep-Soboslay, Amy ; Tao, Ran ; Johnson, Eric O

AbstractSmoking is a leading cause of preventable morbidity and mortality. Smoking is heritable, and genome-wide association studies (GWASs) of smoking behaviors have identified hundreds of significant loci. Most GWAS-identified variants are noncoding with unknown neurobiological effects. We used genome-wide genotype, DNA methylation, and RNA sequencing data in postmortem human nucleus accumbens (NAc) to identify cis-methylation/expression quantitative trait loci (meQTLs/eQTLs), investigate variant-by-cigarette smoking interactions across the genome, and overlay QTL evidence at smoking GWAS-identified loci to evaluate their regulatory potential. Active smokers (N = 52) and nonsmokers (N = 171) were defined based on cotinine biomarker levels and next-of-kin reporting. We simultaneously tested variant and variant-by-smoking interaction effects on methylation and expression, separately, adjusting for biological and technical covariates and correcting for multiple testing using a two-stage procedure. We found >2 million significant meQTL variants (padj < 0.05) corresponding to 41,695 unique CpGs. Results were largely driven by main effects, and five meQTLs, mapping to NUDT12, FAM53B, RNF39, and ADRA1B, showed a significant interaction with smoking. We found 57,683 significant eQTL variants for 958 unique eGenes (padj < 0.05) and no smoking interactions. Colocalization analyses identified loci with smoking-associated GWAS variants that overlapped meQTLs/eQTLs, suggesting that these heritable factors may influence smoking behaviors through functional effects on methylation/expression. One locus containing MUSTN1 and ITIH4 colocalized across all data types (GWAS, meQTL, and eQTL). In this first genome-wide meQTL map in the human NAc, the enriched overlap with smoking GWAS-identified genetic loci provides evidence that gene regulation in the brain helps explain the neurobiology of smoking behaviors.

01 Aug 2024·Life Science Alliance

Chemokine receptor hetero-oligomers regulate monocyte chemotaxis

Article

Author: Gao, Xianlong ; Weche, McWayne ; Majetschak, Matthias ; Enten, Garrett A ; McGee, Michelle Y

It is known that stress influences immune cell function. The underlying molecular mechanisms are unclear. We recently reported that many chemokine receptors (CRs) heteromerize with α1-adrenoceptors (α1-ARs) through which CRs are regulated. Here, we show that arginine vasopressin receptor 1A (AVPR1A) heteromerizes with all human CRs, except chemokine (C-X-C motif) receptor (CXCR)1, in recombinant systems and that such heteromers are detectable in THP-1 cells and human monocytes. We demonstrate that ligand-free AVPR1A differentially regulates the efficacy of CR partners to mediate chemotaxis and that AVPR1A ligands disrupt AVPR1A:CR heteromers, which enhances chemokine (C-C motif) receptor (CCR)1-mediated chemotaxis and inhibits CCR2-, CCR8-, and CXCR4-mediated chemotaxis. Using bioluminescence resonance energy transfer to monitor G protein activation and CRISPR/Cas9 gene-edited THP-1 cells lacking AVPR1A or α1B-AR, we show that CRs that share the propensity to heteromerize with α1B/D-ARs and AVPR1A exist and function within interdependent hetero-oligomeric complexes through which the efficacy of CRs to mediate chemotaxis is controlled. Our findings suggest that hetero-oligomers composed of CRs, α1B/D-ARs, and AVPR1A may enable stress hormones to regulate immune cell trafficking.

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