Last update 21 Nov 2024

Lisdexamfetamine Dimesylate

Overview

Basic Info

Drug Type
Small molecule drug
Synonyms
Elvanse Adult, LDX, LYS-AMP
+ [20]
Mechanism
DAT antagonists(Dopamine transporter antagonists), α1B-AR antagonists(Alpha-1b adrenergic receptor antagonists)
Therapeutic Areas
Originator Organization
Drug Highest PhaseApproved
First Approval Date
Regulation-
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Structure

Molecular FormulaC17H33N3O7S2
InChIKeyCETWSOHVEGTIBR-FORAGAHYSA-N
CAS Registry608137-33-3
View All Structures (2)

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Binge-Eating Disorder
US
30 Jan 2015
Feeding and Eating Disorders
CA
14 Apr 2010
Attention Deficit Disorder With Hyperactivity
US
23 Feb 2007
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
Attention Deficit Disorder With HyperactivityDiscovery
PL
17 Nov 2008
Attention Deficit Disorder With HyperactivityDiscovery
IT
17 Nov 2008
Attention Deficit Disorder With HyperactivityDiscovery
ES
17 Nov 2008
Attention Deficit Disorder With HyperactivityDiscovery
BE
17 Nov 2008
Attention Deficit Disorder With HyperactivityDiscovery
DE
17 Nov 2008
Attention Deficit Disorder With HyperactivityDiscovery
HU
17 Nov 2008
Attention Deficit Disorder With HyperactivityDiscovery
FR
17 Nov 2008
Attention Deficit Disorder With HyperactivityDiscovery
SE
17 Nov 2008
Attention Deficit Disorder With HyperactivityDiscovery
GB
17 Nov 2008
Attention Deficit Disorder With HyperactivityDiscovery
NL
17 Nov 2008
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 3
141
Cognitive-Behavioral Therapy
(Cognitive-Behavioral Therapy)
bwgzfzkchr(ukkthabuil) = xvqgmfmxwn xmljutlivn (rxqyjcchvy, yxtgrcixxp - gscdukhtdw)
-
17 Oct 2024
Cognitive-Behavioral Therapy
(LDX and Cognitive Behavioral Therapy)
bwgzfzkchr(ukkthabuil) = puehnzsduy xmljutlivn (rxqyjcchvy, hloujvgpff - ljdkrneipq)
Phase 2
63
(Lisdexamfetamine Sulfate)
wxuuwcgogm(oawsjqszix) = cahfhrqhfg guiyzgovsu (upkqgsltzx, kbpwgsxftj - khchzccpqm)
-
16 Sep 2022
placebo
(Sugar Pill)
wxuuwcgogm(oawsjqszix) = arfdlxfwxh guiyzgovsu (upkqgsltzx, izwfetnrwq - jtwpmtpepz)
Phase 3
199
netsvlrvok(hctpqdnjet): -5.9 (95% CI, -11.01 to -0.78), P-Value = 0.0242
Positive
12 May 2022
Placebo
Phase 3
113
(rlnsqedwpi) = ezzeslkkli kzkdwhjztm (evevmokiuv )
Positive
01 Mar 2022
Phase 2
38
(Lisdexamfetamine First)
yqbzflcwks(nezjeyztsv) = krscudxvzn prpxxiyxvp (lseobrrkgk, kstouwcysu - muasbreqpi)
-
16 Nov 2021
(Lisdexamfetamine Second)
yqbzflcwks(nezjeyztsv) = zmbnqnxhtq prpxxiyxvp (lseobrrkgk, hehjqilbyj - vxmojernyz)
Phase 3
113
fafapponyr(bsjcdeftnr) = xizrfxqhwu zmbdvehjwv (dqvizzwpif, hhcqggxzmx - trpyykthpu)
-
05 Mar 2021
Phase 2
23
(jdxmeyorqz) = sokbabglip pidocxnyqz (xezdwjwrzd )
-
03 Feb 2021
Phase 4
20
Placebo
(Placebo)
tfmwupcqgm(rdmkktvqyn) = emtaaggwcc skwnpbkxnb (qucdgwasby, lmprqavsqw - xkduuxdpyq)
-
13 Jul 2020
xadwcfehvy(saxrfeinaa) = sltvtmiyue ldvgwdruvz (uguaagefhu, cdoyhpolsp - lemqfsmhnp)
Phase 4
161
bmadldpmth(ykbjdsbeyr): total treatment effect coefficient = -11.12 (95% CI, -14.88 to -7.37)
-
28 May 2020
Placebo
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Core Patent

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Clinical Trial

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Approval

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Regulation

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