Last update 01 Nov 2024

BMP2 x BMP4

Last update 01 Nov 2024

Basic Info

Related Targets

BMP2BMP4

Drugs associated with BMP2 x BMP4

Anti-BMP-2/4 neutralizing antibody (Stem Cell Medicine)

Target

BMP2 x BMP4

Mechanism

BMP2 inhibitors [+1]

Active Org.

Stem Cell Medicine Ltd.

Originator Org.

Stem Cell Medicine Ltd.

Active Indication

Multiple Sclerosis

Inactive Indication-

Drug Highest PhasePreclinical

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

Anti-BMP llama C8C8 antibody (Esocap)

Target

BMP2 x BMP4

Mechanism

BMP2 inhibitors [+1]

Active Org.

Esocap AGStartup

Originator Org.

Esocap AGStartup

Active Indication

Barrett Esophagus

Inactive Indication-

Drug Highest PhasePreclinical

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

100 Clinical Results associated with BMP2 x BMP4

100 Translational Medicine associated with BMP2 x BMP4

0 Patents (Medical) associated with BMP2 x BMP4

1,109

Literatures (Medical) associated with BMP2 x BMP4

01 Oct 2024·Ecotoxicology and Environmental Safety

Polystyrene nanoplastics mediate skeletal toxicity through oxidative stress and the BMP pathway in zebrafish (Danio rerio)

Article

Author: Li, Ye ; Wang, Jun ; Chen, Guanglong ; Zeng, Min ; Liu, Wanjing

The widespread presence of micro(nano)plastics (MNPs) has generated public concern. Studies have indicated that MNPs can accumulate in mammalian bones; however, research on the skeletal toxicity and underlying molecular mechanisms of MNPs in aquatic organisms remains limited. We subjected zebrafish embryos to three varying levels (1, 10, 100 μg/mL) of polystyrene nanoplastics (PSNPs) exposure over a period of 7 days in our research. The results revealed that PSNPs significantly reduced the body length and hatching rate of zebrafish, leading to skeletal deformities. mRNA level analysis showed significant upregulation of sp7, sparc, and smad1 genes transcription by PSNPs. Moreover, PSNPs markedly downregulated the mRNA levels associated with runx2a, bmp2a, and bmp4. Further investigations demonstrated that PSNPs dramatically increased ROS levels in zebrafish larvae, with significant downregulation of transcription levels of sod1 and cat genes, resulting in a sharp increase in transcription levels of apoptosis-related regulatory genes bcl-2 and bax. Furthermore, PSNPs led to a marked rise in Caspase 3 activity in zebrafish larvae, suggesting the initiation of apoptosis. PSNPs also notably inhibited alkaline phosphatase (AKP) activity. Compared to a 4-day exposure, a 7-day exposure to PSNPs intensified abnormalities across multiple indicators. In summary, our research indicates that PSNPs cause significant oxidative stress in zebrafish larvae, resulting in apoptosis. Moreover, PSNPs disrupt the transcription of genes related to skeletal development through the bone morphogenetic protein (BMP) pathway, further disrupting skeletal development processes and ultimately resulting in skeletal deformities in zebrafish larvae. This study provides new insights into the skeletal toxicity of MNPs.

07 Aug 2024·ACS Applied Materials & Interfaces

BMP-Binding Polysulfonate Brushes to Control Growth Factor Presentation and Regulate Matrix Remodelling

Article

Author: Quadir, Fauzia ; Nadal, Clemence ; Migliorini, Elisa ; Lambert, Elisa ; Luo, Jiajun ; Neri-Cruz, Carlos E ; Gautrot, Julien E ; Bogdanović, Bojana ; Marchena, Metzli Hernandez

Bone morphogenetic proteins (BMPs) are important targets to incorporate in biomaterial scaffolds to orchestrate tissue repair. Glycosaminoglycans (GAGs) such as heparin allow the capture of BMPs and their retention at the surface of biomaterials at safe concentrations. Although heparin has strong affinities for BMP2 and BMP4, two important types of growth factors regulating bone and tissue repair, it remains difficult to embed stably at the surface of a broad range of biomaterials and degrades rapidly in vitro and in vivo. In this report, biomimetic poly(sulfopropyl methacrylate) (PSPMA) brushes are proposed as sulfated GAG mimetic interfaces for the stable capture of BMPs. The growth of PSPMA brushes via a surface-initiated activator regenerated by electron transfer polymerization is investigated via ellipsometry, prior to characterization of swelling and surface chemistry via X-ray photoelectron spectroscopy and Fourier transform infrared. The capacity of PSPMA brushes to bind BMP2 and BMP4 is then characterized via surface plasmon resonance. BMP2 is found to anchor particularly stably and at high density at the surface of PSPMA brushes, and a strong impact of the brush architecture on binding capacity is observed. These results are further confirmed using a quartz crystal microbalance with dissipation monitoring, providing some insights into the mode of adsorption of BMPs at the surface of PSPMA brushes. Primary adsorption of BMP2, with relatively little infiltration, is observed on thick dense brushes, implying that this growth factor should be accessible for further binding of corresponding cell membrane receptors. Finally, to demonstrate the impact of PSPMA brushes for BMP2 capture, dermal fibroblasts were then cultured at the surface of functionalized PSPMA brushes. The presence of BMP2 and the architecture of the brush are found to have a significant impact on matrix deposition at the corresponding interfaces. Therefore, PSPMA brushes emerge as attractive coatings for scaffold engineering and stable capture of BMP2 for regenerative medicine applications.

01 Aug 2024·Australian Endodontic Journal

Investigation of polymorphisms in BMP2, BMP4, SMAD6 and RUNX2 genes and pulp stones

Article

Author: Baratto-Filho, Flares ; Gabardo, Marilisa Carneiro Leão ; Thuller, Katherine Azevedo Batistela Rodrigues ; Brancher, João Armando ; Silva-Sousa, Alice Corrêa ; Sousa-Neto, Manoel Damião ; Küchler, Erika Calvano ; Antunes, Lívia Azeredo Alves ; Antunes, Leonardo Santos ; Kublitski, Prescila Mota de Oliveira

AbstractThis study aimed to assess the association between genetic polymorphisms in BMP2 (rs1005464 and rs235768), BMP4 (rs17563), SMAD6 (rs2119261 and rs3934908) and RUNX2 (rs59983488 and rs1200425) and pulp stones (PS). A total of 117 participants, consisting of 63 individuals with PS and 54 without PS, were included. Digital radiographs and a demographic/clinical questionnaire were used. Genomic DNA from salivary cells was genotyped via real‐time polymerase chain reaction. Statistical analyses, including Chi‐Square, Fisher's exact tests, Poisson regression and dimensionality reduction, were conducted. The rs2119261 polymorphism in the SMAD6 gene showed an association with genotype distribution in the recessive model (p = 0.049). The T–T haplotype in the SMAD6 gene (rs2119261 and rs3934908) was more prevalent in the control group and significantly linked with PS (p = 0.029). No associations were found between PS risk and genetic polymorphisms in BMP2, BMP4 and RUNX2. Polymorphisms in the SMAD6 gene were associated with PS.

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