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Last update 08 May 2025

TUB

Last update 08 May 2025

Basic Info

Synonyms

rd5, TUB, TUB bipartite transcription factor

+ [1]

Introduction

Functions in signal transduction from heterotrimeric G protein-coupled receptors. Binds to membranes containing phosphatidylinositol 4,5-bisphosphate. Can bind DNA (in vitro). May contribute to the regulation of transcription in the nucleus. Could be involved in the hypothalamic regulation of body weight (By similarity). Contribute to stimulation of phagocytosis of apoptotic retinal pigment epithelium (RPE) cells and macrophages.

Drugs associated with TUB

MY-1442

Target

TUB

Mechanism

TUB inhibitors

Active Org.

Zhengzhou University

Originator Org.

Zhengzhou University

Active Indication

Neoplasms

Inactive Indication-

Drug Highest PhasePreclinical

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

RS6077

Target

TUB

Mechanism

TUB modulators

Active Org.

North-West University

Originator Org.

Sapienza University of Rome

Active Indication

Leishmaniasis, Visceral

Inactive Indication-

Drug Highest PhasePreclinical

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

SB-216

Target

TUB

Mechanism

TUB inhibitors

Active Org.

The University of Tennessee Health Science Center

Originator Org.

The University of Tennessee Health Science Center

Active Indication

Pancreatic Ductal Adenocarcinoma

Inactive Indication-

Drug Highest PhasePreclinical

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

100 Clinical Results associated with TUB

100 Translational Medicine associated with TUB

0 Patents (Medical) associated with TUB

638

Literatures (Medical) associated with TUB

30 Jun 2025·Fungal Systematics and Evolution

Requienella populi sp. nov. (Requienellaceae, Xylariales) from the bark of living aspen trees in Western Norway

Article

Author: Nordén, B. ; Jordal, J.B. ; Andreasen, M.

The new species Requienella populi in the Requienellaceae is described from Western Norway. Multigene analysis of the four molecular markers ITS, LSU, RPB2 and TUB revealed it as a strongly supported sister clade within the genus. The new species appears to be restricted to old aspen Populus tremula trees and can be morphologically distinguished by submuriform and somewhat smaller ascospores compared to the other species of the genus. A table comparing species of Requienella is provided. The Requienellaceae received a moderate statistical support as a sister group to the Cainiaceae in our analysis and the circumscriptions of the two families need to be studied further using additional genetic markers.

09 Apr 2025·mBio

Storage of the vital metal tungsten in a dominant SCFA-producing human gut microbe Eubacterium limosum and implications for other gut microbes

Article

Author: Shao, Nana ; Chen, Lirong ; Donaghy, Aaron P. ; Coffey, Sydney B. ; Zhou, Dayong ; Poole, Farris L. ; Rose, John ; Thorgersen, Michael P. ; Wang, Bi-Cheng ; Putumbaka, Saisuki ; Schut, Gerrit J. ; Adams, Michael W. W.

ABSTRACT Enzymes containing tungsten rather than the ubiquitous and analogous element molybdenum are prevalent in the human gut microbiome, especifically in microbes that contribute to overall gut health. Eubacterium limosum is a dominant human gut organism whose production of beneficial short-chain fatty acids (SCFAs) from lactate involves tungstoenzymes. Here, we characterized E. limosum Tub, a tungsten storage protein. Tub has a sub-nanomolar affinity for tungstate and contains a single TOBE domain first characterized in a molybdate storage protein. Crystal structures revealed Tub assembles as a hexamer composed of a trimer of dimers, capable of binding eight tungstate oxyanions at two distinct binding sites located at inter-subunit interfaces. Tungstate-saturated Tub exhibited unusually high thermal and chemical stability. Glucose-grown E. limosum accumulates tungsten in Tub and has low levels of two tungstoenzymes, termed WOR1 and FDH, which oxidize aldehydes and formate, respectively. Lactate-grown cells contain high concentrations of these two tungstoenzymes where WOR1 and FDH are involved in converting lactate to SCFAs. Glucose-grown cells appear to accumulate tungstate in Tub in preparation for lactate availability in the human gut. Tub and other TOBE-containing proteins are widespread in the human gut microbiome, and gene co-occurrence analysis predicts that there are comparable numbers of TOBE-containing proteins involved in the storage of tungstate as there are that bind molybdate. The results with E. limosum represent an important step for understanding tungsten storage mechanisms for tungstoenzymes within human gut microbes in general. IMPORTANCE Tungsten metabolism was found to be prevalent in the human gut microbiome, which is involved in the detoxification of food and antimicrobial aldehydes, as well as in the production of beneficial SCFAs. In this study, we characterized a protein in the human gut microbe, Eubacterium limosum , that stores tungstate in preparation for its use in enzymes involved in SCFA generation. This revealed several families of tungstate binding proteins that are also involved in tungstate transport and tungstate-dependent regulation and are widely distributed in the human gut microbiome. Elucidating how tungsten is stored and transported in the human gut microbes contributes to our understanding of the human gut microbiome and its impact on human health.

04 Mar 2025·Mycobiology

Gliocladiopsis koreensis sp. nov., Ilyonectria koreensis sp. nov., and Mariannaea koreensis sp. nov. (Nectriaceae), Novel Fungi Isolated from Soil in Jeju Island and Upo Wetland in the Republic of Korea

Article

Author: Noh, HyeongJin ; Kim, Seong Hwan

In this study, three novel fungal species belonging to the Nectriaceae family, Gliocladiopsis koreensis sp. nov., Ilyonectria koreensis sp. nov., and Mariannaea koreensis sp. nov., were discovered from soil samples collected at Iseung-ak Oreum on Jeju Island and the Upo Wetland in Changnyeong, Republic of Korea. They were confirmed as distinct species through molecular phylogenetic analyses using the ITS, TUB, Tef1, HIS3, and LSU sequences. Maximum-likelihood and Bayesian inference trees show that G. koreensis forms a sister clade with G. curvata, G. singaporiensis, and G. peggii, I. koreensis clusters closely with I. qitaiheensis and I. changbaiensis, and M. koreensis is phylogenetically related to M. atlantica, M. fusiformis, M. elegans var. punicea, and M. terricola. While all three new species exhibit unique morphological characteristics such as colony growth patterns, pigmentation, and microstructures that differentiate them from their closest relatives. The findings of these novel species contribute to the understanding of fungal diversity in these ecologically significant regions and highlight their potential applications in agriculture, nutrient cycling, and environmental restoration.

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