Last update 08 May 2025

RANGRF

Basic Info

Synonyms
HSPC165, HSPC236, MOG1
+ [4]
Introduction
May regulate the intracellular trafficking of RAN (PubMed:11290418). Promotes guanine nucleotide release from RAN and inhibits binding of new GTP by preventing the binding of the RAN guanine nucleotide exchange factor RCC1 (PubMed:29040603). Regulates the levels of GTP-bound RAN in the nucleus, and thereby plays a role in the regulation of RAN-dependent mitotic spindle dynamics (PubMed:29040603). Enhances the expression of SCN5A at the cell membrane in cardiomyocytes (PubMed:18184654, PubMed:21621375, PubMed:23420830).

Related

1
Drugs associated with RANGRF
AAV9-MOG1
Target
RANGRF
Mechanism
RANGRF modulators
Active Org.
The Cleveland Clinic FoundationThe Cleveland Clinic Foundation
Originator Org.
The Cleveland Clinic FoundationThe Cleveland Clinic Foundation
Active Indication
Brugada Syndrome
Inactive Indication-
Drug Highest PhasePreclinical
First Approval Ctry. / Loc.-
First Approval Date20 Jan 1800
100 Clinical Results associated with RANGRF
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100 Translational Medicine associated with RANGRF
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0 Patents (Medical) associated with RANGRF
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59
Literatures (Medical) associated with RANGRF
01 Sep 2023Stem Cell Research
Generation of a homozygous RANGRF knockout hiPSC line by CRISPR/Cas9 system
01 Sep 2022Biochimica et Biophysica Acta (BBA) - Molecular Basis of DiseaseQ2 · BIOLOGY
Mog1 deficiency promotes cardiac contractile dysfunction and isoproterenol-induced arrhythmias associated with cardiac fibrosis and Cx43 remodeling
Q2 · BIOLOGY
01 Aug 2022Nature Reviews Cardiology
Gene therapy for Brugada syndrome

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