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Last update 08 May 2025

bFGF x VEGFR

Last update 08 May 2025

Basic Info

Related Targets

bFGFVEGFR

Drugs associated with bFGF x VEGFR

BMS-584622

Target

PDGFRs x VEGFR1 x VEGFR2 x VEGFR3 x bFGF

Mechanism

PDGFR antagonists [+4]

Active Org.-

Originator Org.

Bristol Myers Squibb Co.

Active Indication-

Inactive Indication

Vascular Diseases

Drug Highest PhaseDiscontinued

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

SU-9803

Target

VEGFR x bFGF

Mechanism

VEGFR antagonists [+1]

Active Org.-

Originator Org.

Sugen, Inc.

Active Indication-

Inactive Indication

Glioma

Drug Highest PhasePending

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

R-90324

Target

VEGFR x bFGF

Mechanism

VEGFR antagonists [+1]

Active Org.-

Originator Org.

The Janssen Research Foundation

Active Indication-

Inactive Indication

Neoplasms

Drug Highest PhasePending

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

100 Clinical Results associated with bFGF x VEGFR

100 Translational Medicine associated with bFGF x VEGFR

0 Patents (Medical) associated with bFGF x VEGFR

635

Literatures (Medical) associated with bFGF x VEGFR

21 Mar 2025·Int. Journal of Clinical Pharmacology and Therapeutics

Network pharmacology of ginsenoside Rg3 in the treatment of ovarian cancer: Mechanism of action and experimental verification

Article

Author: Lu, Xizi ; Ding, Xiaofeng ; Wei, Liliang ; Zhu, Lujia ; Yun, Yi ; Zhu, Yibo ; Li, Xiang ; Ren, Boyu ; Zeng, Guishu

OBJECTIVEThe aim of this study was to investigate the mechanism of action of ginsenoside Rg3 (Rg3) in the treatment of ovarian cancer (OC).MATERIALS AND METHODSWe used a network pharmacology approach to identify overlapping targets of OC- and Rg3-related genes. The overlapping targets were used for enrichment analysis to construct protein-protein interaction (PPI) networks and identify hub genes. Significantly enriched pathways were validated using in vitro experiments.RESULTSAfter identifying the relevant targets of OC and Rg3, 53 overlapping targets were identified. Enrichment analysis revealed that the PI3K-Akt, Ras, Rap1 pathways were significantly enriched. Ten hub genes (AKT1, MMP9, STAT3, JUN, MMP2, EGFR, FGF2, PPARG, KDR, and HSP90AA1) were identified in the PPI network. In vitro experiments revealed that Rg3 exerted therapeutic effects by promoting the apoptosis of OC cells and inhibiting the PI3K-Akt signaling pathway.CONCLUSIONThe combination of network pharmacology and in vitro experimental validation revealed that Rg3 may play a therapeutic role in the treatment of OC by promoting the apoptosis of OC cells via the inhibition of the PI3K-Akt signaling pathway. This provides a new idea for the clinical application of Rg3 in the treatment of OC.

01 Mar 2025·Advances in Medical Sciences

Knockout of histone deacetylase 8 gene in breast cancer cells may alter the expression pattern of the signaling molecules

Article

Author: Abdi, Mohammad ; Bahrami, Nahid

PURPOSEBreast cancer (BC) is the most common cancer diagnosed in the world and it is also the main leading cause of cancer deaths in women. Change in epigenetic mechanisms promotes BC initiation and progression. Histone deacetylase 8 (HDAC8) was found to act as a potential oncogene in different malignancies. For better understanding of the HDAC8 function in BC development, we investigated the effect of HDAC8 deletion on the expression of genes involved in signaling pathways.MATERIALS AND METHODSIn this study, CRISPR technology was used to knockout the HDAC8 gene in MDA-MB-468, MDA-MB-231 and MCF-7 cell lines. For this purpose, two gRNAs were designed and cloned into the PX459 vector. The gRNA-containing vectors were transfected into the BC cell lines and then the effect of this deletion on the expression of genes involved in signaling pathway was determined using quantitative real-time PCR (qRT-PCR).RESULTSAnalysis of qRT-PCR results showed a reduction in the expression of studied genes in BC cell lines after deletion of the HDAC8 gene compared to untreated controls. Although this decline was not significant for FGF2 and FGFR1 genes, however the mTOR, IGF1R, INSR, VEGFA and VEGFR2 genes showed statistically significant reduction in the studied BC cell lines. In addition, the down-regulation of PDGFC and PDGFRA genes were only significant in the TNBC cell lines.CONCLUSIONOverall, our study showed that HDAC8 can exert its oncogenic effects by altering the expression level of molecules involved in some signaling pathways, and inhibiting HDAC8 can revert these effects.

01 Jan 2025·Journal of Animal Science and Technology

Genetic insights into avian influenza resistance in Jeju Island chickens: the roles of Mx1 and oligoadenylate synthetase-like single nucleotide polymorphisms

Article

Author: Jeong, Seohyun ; Yang, Hyoung-Seok ; Ko, Eun-A ; Ko, Jae-Hong ; Yang, Ju-Hee ; Kim, Young-Won ; Kang, Sung Hyun ; Tark, Dongseob ; Mun, Seong-Hwan ; Kim, Woo Hyun

Influenza A virus (FLUAV) causes serious diseases in both poultry and humans. Various host proteins, including Mx1, are considered candidates for avian influenza (AI) resistance. After infecting Jeju Native chicken embryo fibroblasts (CEFs) with three types of AI viruses, we performed gene expression profiling, identified single nucleotide polymorphisms (SNPs) through RNA-sequencing, and confirmed phenotypes showing antiviral activity in vitro. Highly pathogenic AI viruses upregulated FGF2, LYN, and FLT4 and downregulated HGF, ANGPT1, and ROR2, while a low pathogenicity AI upregulated PARK7, RACK1, and DTX3L and downregulated SIRT1, LRRK2, and WAC. However, no virus affected Mx1 expression. Although SNPs in Mx1 could not discriminate antiviral activity alone, the only CEF resistant to H5N6, strain AN4, contained the Mx1 631 R/R genotype and strongly expressed an oligoadenylate synthetase-like (OASL) variant with a unique SNP: c.G880A (p.E294K). Using transfected cell lines, H5N6-infected cells expressing OASL with the c.G880A SNP showed minimal cytopathic effects and the lowest M gene expression. This study confirms that Jeju Native chickens with specific SNP combinations in both Mx1 and OASL showed H5N6 resistance and demonstrates the interplay of genetic factors in host-pathogen dynamics, suggesting a need for integrated analyses of multiple resistance genes to inform AI prevention strategies.

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