Synonyms casein kinase 1 alpha 1, casein kinase 1, alpha 1, Casein kinase I isoform alpha + [8] |
Introduction Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates (PubMed:18305108, PubMed:11955436, PubMed:1409656, PubMed:23902688). It can phosphorylate a large number of proteins (PubMed:18305108, PubMed:11955436, PubMed:1409656, PubMed:23902688). Participates in Wnt signaling (PubMed:11955436). Phosphorylates CTNNB1 at 'Ser-45' (PubMed:11955436). May phosphorylate PER1 and PER2 (By similarity). May play a role in segregating chromosomes during mitosis (PubMed:1409656). May play a role in keratin cytoskeleton disassembly and thereby, it may regulate epithelial cell migration (PubMed:23902688). Acts as an inhibitor of NLRP3 inflammasome assembly by mediating phosphorylation of NLRP3 (By similarity). |
Mechanism CK1α inhibitors [+7] |
Active Org. |
Originator Org. |
Active Indication |
Inactive Indication |
Drug Highest PhaseApproved |
First Approval Ctry. / Loc. US |
First Approval Date27 Dec 2005 |
Target |
Mechanism CDK7 gene inhibitors [+2] |
Active Org. |
Originator Org. |
Active Indication |
Inactive Indication- |
Drug Highest PhasePhase 2 |
First Approval Ctry. / Loc.- |
First Approval Date20 Jan 1800 |
Target |
Mechanism CK1α inhibitors |
Active Org. |
Originator Org. |
Active Indication |
Inactive Indication- |
Drug Highest PhasePhase 1 |
First Approval Ctry. / Loc.- |
First Approval Date20 Jan 1800 |
Start Date17 Jan 2025 |
Sponsor / Collaborator |
Start Date01 Jan 2025 |
Sponsor / Collaborator |
Start Date31 Dec 2024 |
Sponsor / Collaborator |