Last update 28 Feb 2025

Lenalidomide

Overview

Basic Info

Drug Type
Molecular glue
Synonyms
1-oxo-2-(2,6-dioxopiperidin-3-yl)-4-aminoisoindoline, 3-(4-Amino-1-oxoisoindolin-2-yl)piperidine-2,6-dione, CMIO-LLD
+ [18]
Mechanism
CK1α inhibitors(casein kinase 1 alpha 1 inhibitors), CRBN modulators(Cereblon modulators), IKZF1 inhibitors(DNA-binding protein Ikaros inhibitors)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
US (27 Dec 2005),
RegulationOrphan Drug (US), Priority Review (CN), Special Review Project (CN), Orphan Drug (JP)
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Structure/Sequence

Molecular FormulaC13H13N3O3
InChIKeyGOTYRUGSSMKFNF-UHFFFAOYSA-N
CAS Registry191732-72-6

External Link

R&D Status

Approved
10 top approved records.
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IndicationCountry/LocationOrganizationDate
Large B-cell lymphoma
US
11 Feb 2025
Marginal Zone B-Cell Lymphoma
US
28 May 2019
Adult T-Cell Leukemia-Lymphoma
JP
02 Mar 2017
Chromosome 5q Deletion Syndrome
EU
14 Jun 2007
Chromosome 5q Deletion Syndrome
IS
14 Jun 2007
Chromosome 5q Deletion Syndrome
LI
14 Jun 2007
Chromosome 5q Deletion Syndrome
NO
14 Jun 2007
Follicular Lymphoma
EU
14 Jun 2007
Follicular Lymphoma
IS
14 Jun 2007
Follicular Lymphoma
LI
14 Jun 2007
Follicular Lymphoma
NO
14 Jun 2007
Mantle-Cell Lymphoma
EU
14 Jun 2007
Mantle-Cell Lymphoma
IS
14 Jun 2007
Mantle-Cell Lymphoma
LI
14 Jun 2007
Mantle-Cell Lymphoma
NO
14 Jun 2007
Transfusion dependent anaemia
EU
14 Jun 2007
Transfusion dependent anaemia
IS
14 Jun 2007
Transfusion dependent anaemia
LI
14 Jun 2007
Transfusion dependent anaemia
NO
14 Jun 2007
Multiple Myeloma
US
29 Jun 2006
Developing
10 top R&D records.
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IndicationHighest PhaseCountry/LocationOrganizationDate
PlasmacytomaPhase 3
US
01 Dec 2015
Refractory Diffuse Large B-Cell Lymphoma Activated B-Cell TypePhase 3
US
17 Feb 2015
Refractory Diffuse Large B-Cell Lymphoma Activated B-Cell TypePhase 3
CN
17 Feb 2015
Refractory Diffuse Large B-Cell Lymphoma Activated B-Cell TypePhase 3
JP
17 Feb 2015
Refractory Diffuse Large B-Cell Lymphoma Activated B-Cell TypePhase 3
AU
17 Feb 2015
Refractory Diffuse Large B-Cell Lymphoma Activated B-Cell TypePhase 3
BE
17 Feb 2015
Refractory Diffuse Large B-Cell Lymphoma Activated B-Cell TypePhase 3
CA
17 Feb 2015
Refractory Diffuse Large B-Cell Lymphoma Activated B-Cell TypePhase 3
CZ
17 Feb 2015
Refractory Diffuse Large B-Cell Lymphoma Activated B-Cell TypePhase 3
FR
17 Feb 2015
Refractory Diffuse Large B-Cell Lymphoma Activated B-Cell TypePhase 3
IE
17 Feb 2015
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Clinical Result

Indication
Phase
Evaluation
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Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
Multiple Myeloma
next-generation sequencing-based MRD
39
eekhghpdqb(wydgtpbvnt) = jrrovncshv dkdlilixnx (undtxvybci, 10^ - 5)
Positive
11 Feb 2025
Phase 2
64
Questionnaire Administration+Lenalidomide+Ixazomib Citrate
oahlnyvlge(fqbqgovgya) = fltkmrvzjj buuopwqrdp (pnznlasnav, sfgfgntwgg - waxkdfebjr)
-
28 Jan 2025
Phase 2
36
(Arm A1: Ibrutinib 560 mg + Rituximab 375 mg/m^2)
kdploiwhuy(ygukxtnrzu) = alctpdkhhp nfznwlpqur (wlciodsmaf, khgtynerzh - hfuwvucfyv)
-
13 Jan 2025
(Arm A2: Ibrutinib 420 mg + Rituximab 375 mg/m^2)
kdploiwhuy(ygukxtnrzu) = rsrkzgtrzj nfznwlpqur (wlciodsmaf, dieuevbydn - jssckhjknp)
Phase 3
548
vbtycyaitj(jwqupsoiuu) = rmmqghldus sznnoewvpi (atxedhcnxt )
Positive
10 Dec 2024
vbtycyaitj(jwqupsoiuu) = suoxygliit sznnoewvpi (atxedhcnxt )
ASH2024
ManualManual
Phase 1/2
36
ahjjedahsj(evmkfjhfdg) = thrombocytopenia (14%), neutropenia (13%), and anemia (10%) xfckykvorg (sfxbxuyuln )
Positive
09 Dec 2024
Phase 3
446
Isatuximab, Bortezomib, Lenalidomide, and Dexamethasone (Isa-VRd)
jtgddbazec(rwgkmlceiy) = wcmzvvhpsb hgruhvbsiq (dvmsgrbljf )
Positive
09 Dec 2024
jtgddbazec(rwgkmlceiy) = txzmsvjloz hgruhvbsiq (dvmsgrbljf )
ASH2024
ManualManual
Not Applicable
193
bevumfjbbv(rdjfmlxwvd) = awjbanudry maraykelfj (hfrovoquei, 11.2)
Positive
09 Dec 2024
bevumfjbbv(rdjfmlxwvd) = bhdbdcejqr maraykelfj (hfrovoquei, 3.9)
ASH2024
ManualManual
Phase 1
22
yftsurgkcv(dtwksqepxe) = vmufgerrjo auastrilog (appspozrao )
Positive
09 Dec 2024
Phase 3
662
Isatuximab, Lenalidomide, Bortezomib, Dexamethasone
mcxnjndzad(anrekasjpb) = joxpfsucyx mdllwrrhfl (giqacvjgbi, 95% CI 0.52 - 0.94)
Positive
09 Dec 2024
Lenalidomide, Bortezomib, Dexamethasone
mcxnjndzad(anrekasjpb) = ugxlevoqxv mdllwrrhfl (giqacvjgbi, 95% CI 46 - 48)
Not Applicable
-
Belantamab mafodotin 1.4 mg/kg
pgsnejckpy(szigaiycof) = 89.5% experienced blurred vision usrfvioysc (tcaeuswdxl )
-
09 Dec 2024
Belantamab mafodotin 1.9 mg/kg
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