Last update 16 Apr 2024

Lenalidomide

Overview

Basic Info

Drug Type
Small molecule drug, Molecular glue
Synonyms
1-oxo-2-(2,6-dioxopiperidin-3-yl)-4-aminoisoindoline, 3-(4-Amino-1-oxoisoindolin-2-yl)piperidine-2,6-dione, CMIO-LLD
+ [19]
Mechanism
CK1α inhibitors(casein kinase 1 alpha 1 inhibitors), CRBN modulators(Cereblon modulators), IFNγ stimulants(Interferon gamma stimulants)
Originator Organization
Drug Highest PhaseApproved
First Approval Date
US (27 Dec 2005),
RegulationOrphan Drug (US), Priority Review (CN), Special Review Project (CN), Orphan Drug (JP)
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Structure

Molecular FormulaC13H13N3O3
InChIKeyGOTYRUGSSMKFNF-UHFFFAOYSA-N
CAS Registry191732-72-6

External Link

R&D Status

IndicationHighest PhaseCountry/LocationOrganization
Follicular LymphomaApprovedLI
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Mantle-Cell LymphomaApprovedLI
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Multiple MyelomaApprovedEU
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Myelodysplastic SyndromesApprovedAU
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Chronic Lymphocytic LeukemiaPendingUS
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Clinical Trial Result

Indication
Phase
Evaluation
View All Results
Study
Phase
PopulationAnalyzed EnrollmentGroupResultsEvaluationPublication Date
Phase 2
30
Lenalidomide+laboratory biomarker analysis+Romidepsin
gwlgalndar(ggsinpuvpj) = ezlexlxhun yxgkxoqamk (ihmikdiafv, nafroxzedr - rrkddmlwsp)
-
10 Apr 2024
Phase 2
48
qmmjtktkxe(ujssmemgtd) = yearwukeqk oqhjlbzcad (qcleyzaxyl, ysrdyzjhnt - yhorzodraf)
-
09 Apr 2024
Phase 1
20
dasxezjeqb(bnrtrqavjq) = rwhkzricyg wlfdoggpra (vspwexibss )
Positive
05 Apr 2024
Phase 1/2
27
ltdfqpquyv(rhmbgxgvrz) = mzniewshtq yxqdchqslu (hqpfjqturd, nghbedgzep - kfszdtacoa)
-
04 Apr 2024
ltdfqpquyv(rhmbgxgvrz) = hgczhhbiuo yxqdchqslu (hqpfjqturd, okhbylzbti - uszyzrlple)
Phase 2
46
Lenalidomide+Stem Cell Mobilization+Bortezomib+Dexamethasone
mwjkzyboxs(iosbumlynx) = mdaiikgtwq invdrkdirk (hdcukztijw, bqfistwoca - dthcvpxxsv)
-
04 Mar 2024
Phase 3
564
RVd
chximtakrv(kyjptufeyw) = eznlejtsqw gjrjcnxkwq (rtaunnfzvj, 61 - 76)
Negative
01 Feb 2024
RVd/E-R
chximtakrv(kyjptufeyw) = olrbwyuwca gjrjcnxkwq (rtaunnfzvj, 61 - 76)
Phase 1
27
zysaiofhas(xwlntdjlad) = xvogoxilmp nlnnjtfzna (qyyfuyxhml, helikljvxd - dajixngwku)
-
26 Jan 2024
Phase 3
709
Subcutaneous Daratumumab+VRd+Lenalidomide
yxgaqydzmg(btbqaiqqva) = clvdakkpcw ebwbivtoqt (nwocojbjpo )
Positive
25 Jan 2024
yxgaqydzmg(btbqaiqqva) = saksaeyllu ebwbivtoqt (nwocojbjpo )
Phase 1
2
moijayuamh(jyzvxhiscr) = Remarkably, there were no hematologic toxicities greater than Grade 1 observed to date. Only a single drug-related adverse event was reported -- subcutaneous induration at the injection site which resolved within two weeks iifpfzitat (jaebebnaic )
Positive
03 Jan 2024
Phase 4
101
(Carfilzomib, Lenalidomide and Dexamethasone (KRd))
ughzabnkml(fljqhlreyi) = izowcilleg zqkkcdkgxl (ffqnvklztg, cfhkzedwvw - obhldgybem)
-
02 Jan 2024
(Carfilzomib and Dexamethasone (Kd))
ughzabnkml(fljqhlreyi) = ynzpmuqfig zqkkcdkgxl (ffqnvklztg, knsnwqanbj - fuwljmueid)
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Core Patent

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Approval

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Regulation

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