Last update 01 Nov 2024

PPAR x LPL

Last update 01 Nov 2024

Basic Info

Related Targets

PPARLPL

Drugs associated with PPAR x LPL

ZBH-2011-02

Target

LPL x PPAR

Mechanism

LPL stimulants [+1]

Active Org.-

Originator Org.

Academy of Military Med Sci, Inst of Toxicology & Pharmacology

Active Indication-

Inactive Indication

Hyperlipidemias

Drug Highest PhasePending

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

100 Clinical Results associated with PPAR x LPL

100 Translational Medicine associated with PPAR x LPL

0 Patents (Medical) associated with PPAR x LPL

1,179

Literatures (Medical) associated with PPAR x LPL

01 Jan 2025·Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology

Hyperthermal stress potentiates enhanced lipid utilisation in genetically improved farmed Tilapia, Oreochromis niloticus juveniles

Article

Author: Dasgupta, Subrata ; Mannur, Vijayakumar Sidramappa ; Varghese, Tincy ; Akhila, S. ; Akhila, S ; Sahu, Narottam Prasad ; Chandan, Nitish Kumar ; Paul Nathaniel, T. ; Deo, Ashutosh D. ; Nathaniel T, Paul ; Deo, Ashutosh D ; Gupta, Subodh

The present experiment evaluated whether dietary protein (P) or lipid (L) is preferred as an energy source by genetically improved farmed tilapia (GIFT) reared at high temperatures. A 60-day feeding trial was conducted at 28.3 °C and 33.3 °C, testing five diets with varying protein (34,36,38 %) and lipid (8,10,12 %) levels, viz., P₃₈L₈, P₃₆L₈, P₃₄L₈, P₃₄L₁₀, P₃₄L₁₂. Parameters assessed included growth, body composition, serum lipids, enzyme activities, fatty acid profiles, and PPAR-α mRNA expression. Results indicated that the fish fed optimum protein and highest lipid level (P₃₄L₁₂) showed significantly higher (P < 0.05) weight gain percent and thermal growth coefficient. Increasing dietary lipid content reduced whole-body lipid deposition and mobilised serum triglycerides and cholesterol at higher temperatures (HT). Hepatic malic enzyme activity decreased with rising temperature and lipid content, while lipoprotein lipase activity in muscle increased. The fatty acid composition altered substantially with the changes in rearing temperature and diets. Unsaturated fats were preferred as direct fuels for β-oxidation, wherein the P₃₄L₁₂ groups preserved body (area %) EPA, DHA, and linolenic acid, especially at HT. The expression of PPAR-α, a lipolytic marker, was upregulated with increasing temperature and high dietary lipid content, peaking in P₃₄L₁₂ groups. The study concludes that high-lipid diets (12 %) are metabolically superior to high-protein diets for GIFT tilapia at elevated temperatures, optimising growth, enhancing metabolic efficiency, and maintaining essential fatty acid profiles under hyperthermal stress.

16 Dec 2024·Animal Biotechnology

Effect of DHCR7 on adipocyte differentiation in goats

Article

Author: Hu, Tingting ; Lin, Yaqiu ; Wang, Yong ; Jiani, Xing ; Li, Zhibin ; Li, Yanyan ; Li, Jinlan ; Li, Ruiwen ; Wang, Youli

Cholesterol is regarded as a signaling molecule in regulating the metabolism and function of fat cells, in which 7-Dehydrocholesterol reductase (DHCR7) is a key enzyme that catalyzes the conversion of 7-dehydrocholesterol to cholesterol, however, the exact function of DHCR7 in goat adipocytes remains unknown. Here, the effect of DHCR7 on the formation of subcutaneous and intramuscular fat in goats was investigated in vitro, and the result indicated that the mRNA level of DHCR7 showed a gradual downward trend in subcutaneous adipogenesis, but an opposite trend in intramuscular adipogenesis. In the process of subcutaneous preadipocytes differentiation, overexpression of DHCR7 inhibited the expression of adipocytes differentiation marker genes (CEBP/α, CEBP/β, SREBP1 and AP2), lipid metabolism-related genes (AGPAT6, FASN, SCD1 and LPL), and the lipid accumulation. However, in intramuscular preadipocyte differentiation, DHCR7 overexpression showed a promoting effect on adipocyte differentiation marker genes (CEBP/α, CEBP/β, PPARγ and SREBP1) and lipid metabolism-related genes (GPAM, AGPAT6, DGAT1 and SCD1) expression, and on lipid accumulation. In summary, our work demonstrated that DHCR7 played an important role in regulating adipogenic differentiation and lipid metabolism in preadipocytes in goats, which is of great significance for uncovering the underlying molecular mechanism of adipocyte differentiation and improving goat meat quality.

01 Nov 2024·Poultry Science

Butyric acid reduced lipid deposition in immortalized chicken preadipocyte by inhibiting cell proliferation and differentiation

Article

Author: Wang, Chaohui ; Liu, Xiaoying ; Li, Yun ; Liu, Yanli ; Sun, Xi ; Yang, Xiaojun ; Qin, Kailong

The hyperplasia and hypertrophy of preadipocytes were closely related to lipid deposition in animals. Butyric acid was reported to be involved in lipid metabolism. The aim of the current study was to investigate the effect of butyric acid on the proliferation and differentiation of the immortalized chicken preadipocyte 2 (ICP2). ICP2 were treated respectively with 12mM butyric acid for 48h in proliferation trial and 4mM butyric acid plus 200 μM oleic acid for 3 d in differentiation trial. For the proliferation trial, RNA-seq analysis revealed that 2039 genes were significantly up-regulated and 780 genes were significantly down-regulated with 12 mM butyric acid after 48 h treatment. Concurrently, Cell cycle, DNA replication and p53 signaling pathways were down-regulated in Butyric acid group. More importantly, 12 mM butyric acid restrained the expression of cell proliferation genes such as PCNA, CDK1 and CDK2 in Butyric acid group (P < 0.05), and the protein expression levels of PCNA and CDK1 were also significantly decreased (P < 0.05). The Oil red staining revealed a fewer presence of red fat droplets in ICP2 following treatment with 4 mM butyric acid, accompanied by decreased levels of total cholesterol (TC) and triglycerides (TG). RNA-seq analysis shown that the number of up and down-regulated genes were 2095 and 1042 respectively in OAB group (oleic acid+butyric acid) when compared with OA group (oleic acid). Meanwhile the AMPK signaling pathway, FOXO signaling pathway and focal adhesion were significantly enriched in OAB group. Additionally, 4 mM butyric acid inhibited the expression of lipid differentiation genes including FABP4, C/EBPα, PPARγ and LPL in OAB group (P < 0.05), as well as lipogenesis proteins such as FABP4, C/EBP-α and PPARγ (P < 0.05). In conclusion, 12 mM butyric acid effectively inhibited the proliferation of ICP2 by slowing down cell cycle progression, while 4 mM butyric acid alleviated lipid deposition by reducing the production of lipid droplets through inhibiting the expression of lipid differentiation marker genes and proteins.

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