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Last update 08 May 2025

MILR1

Last update 08 May 2025

Basic Info

Synonyms

Allergin-1, Allergy inhibitory receptor 1, C17orf60

+ [6]

Introduction

Immunoglobulin-like receptor which plays an inhibitory role in degranulation of mast cells. Negatively regulates IgE-mediated mast cell activation and suppresses the type I immediate hypersensitivity reaction (By similarity).

Drugs associated with MILR1

Anti Allergin-1 bispecific antibody (Ono Pharmaceutical)

Target

MILR1

Mechanism

MILR1 antagonists

Active Org.-

Originator Org.

Ono Pharmaceutical Co., Ltd.

Active Indication-

Inactive Indication

Neoplasms

Drug Highest PhasePending

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

100 Clinical Results associated with MILR1

100 Translational Medicine associated with MILR1

0 Patents (Medical) associated with MILR1

Literatures (Medical) associated with MILR1

01 Apr 2025·Gene

Comparative genome analysis of international transboundary cattle breeds

Article

Author: Ganguly, Indrajit ; Yadav, Anuka ; Dharamshaw, C A ; Dixit, S P ; Chinnareddyvari, Chandana Sree ; Singh, Sanjeev

Indian-origin Gir and Ongole cattle are international transboundary breeds that are reared in Brazil, The United States, Mexico, Malaysia, Panama, and other nations to provide meat and dairy products. These breeds have shown substantial genetic diversity in recent years and well suited to the ecological niche in Brazil. 90 cattle samples of Indian Gir (n = 15), Ongole (n = 17), Brazilian Gyr (n = 27), and Nellore (n = 31) breeds were genotyped using Illumina BovineHD BeadChip. Samples were analyzed to identify selection signature using two complementing approaches: Integrated Haplotype Score (iHS) and Fixation Index (FST). Gir versus Gyr and Ongole versus Nellore revealed Pairwise FST differences of 2.85 % and 2.35 %, respectively. Using integrated haplotype score (iHS) method, 4004, 3322, 3437, and 3485 genes were found in Gir, Gyr, Ongole, and Nellore, respectively, underlying top 1 % of selected regions. Under top 1 % of selected regions, FST based method identified1897 genes for the Ongole-Nellore pair and 1966 genes for the Gir-Gyr pair. Runs of homozygosity (ROH) analysis revealed that both recent as well as ancient inbreeding in these breeds were in range of 2.6-4.5 % indicating populations to be less inbred. Numerous candidate genes, including IER5, MILR1 (immunity related traits) in Gir; and FGF12, SV2C, JMY (average daily gain, body size, reproduction related traits) in Ongole, were found under the top-selected regions. Nellore breed had carcass/growth traits (PARP2, and KCNJ11) and genes linked to mammary gland development, udder size, and carcass (MYO16, MYO1B) were found in Gyr. Present findings reveals that Brazilian cattle population (Gyr and Nellore) is more selected for carcass and growth traits along with milk production traits, whereas in Indian cattle population (Gir and Ongole) selection signature related to immunity and adaptation were more prominent. Further, sufficient genetic diversity exist within these cattle breeds for their genetic improvement.

08 Jun 2024·International Immunology

An inhibitory immunoreceptor Allergin-1 regulates the intestinal dysbiosis and barrier function in mice

Article

Author: Shibuya, Akira ; Fukuda, Shinji ; Obana, Nozomu ; Lin, Yu-Hsien ; Tahara-Hanaoka, Satoko

AbstractThe intestinal barrier consists of mucosal, epithelial, and immunological barriers and serves as a dynamic interface between the host and its environment. Disruption of the intestinal barrier integrity is a leading cause of various gastrointestinal diseases, such as inflammatory bowel disease. The homeostasis of the intestinal barrier is tightly regulated by crosstalk between gut microbes and the immune system; however, the implication of the immune system on the imbalance of gut microbes that disrupts barrier integrity remains to be fully elucidated. An inhibitory immunoglobulin-like receptor, Allergin-1, is expressed on mast cells and dendritic cells and inhibits Toll-like receptor (TLR)-2 and TLR-4 signaling in these cells. Since TLRs are major sensors of microbiota and are involved in local epithelial homeostasis, we investigated the role of Allergin-1 in maintaining intestinal homeostasis. Allergin-1-deficient (Milr1−/−) mice exhibited more severe dextran sulfate sodium (DSS)-induced colitis than did wild-type (WT) mice. Milr1−/− mice showed an enhanced intestinal permeability compared with WT mice even before DSS administration. Treatment of Milr1−/− mice with neomycin, but not ampicillin, restored intestinal barrier integrity. The 16S rRNA gene sequencing analysis demonstrated that Bifidobacterium pseudolongum was the dominant bacterium in Milr1−/− mice after treatment with ampicillin. Although the transfer of B. pseudolongum to germ-free WT mice had no effect on intestinal permeability, its transfer into ampicillin-treated WT mice enhanced intestinal permeability. These results demonstrated that Allergin-1 deficiency enhanced intestinal dysbiosis with expanded B. pseudolongum, which contributes to intestinal barrier dysfunction in collaboration with neomycin-sensitive and ampicillin-resistant microbiota.

01 Dec 2023·Allergy

Annexin A5 inhibits mast cell activation via Allergin‐1 immunoreceptor

Letter

Author: Hitomi, Kaori ; Shibuya, Akira ; Shinkai, Yasuhiro ; Almeida, Mariana Silva ; Shibayama, Shiro ; Tahara-Hanaoka, Satoko ; Shibagaki, Shohei ; Niizuma, Kouta

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MILR1

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