PAX8

Presentations on cMyc, ADAR1, and PAX8 inhibitors to be held on October 25, 2024 SAN JOSE, Calif., Oct. 9, 2024 /PRNewswire/ -- BridGene Biosciences, a leader in the discovery of small molecule drugs for traditionally "hard-to-drug" targets, today announced it will present three groundbreaking posters at the American Association for Cancer Research (AACR) 2024 Annual Meeting in Barcelona, on October 25, 2024. The posters will showcase the company's latest advancements in the development of covalent inhibitors for key oncogenic targets, including cMyc, ADAR1, and PAX8, each representing promising new treatment avenues for various cancers. "These three presentations represent significant strides in our mission to develop novel therapeutics for cancer patients," said Ping Cao, Ph.D., Co-Founder and CEO of BridGene Biosciences. "By focusing on these high-value, historically hard-to-drug targets, we aim to create first-in-class therapies that address critical gaps in cancer treatment. Our platform continues to unlock new possibilities in drug discovery, and we are excited to share these advancements with the scientific community at AACR." BridGene's work on cMyc, titled "Discovery of a Covalent Inhibitor Targeting the Undruggable Oncogene cMyc," focuses on overcoming the challenges posed by its intrinsically disordered structure, which has historically rendered the protein hard-to-drug. Through its proprietary Isobaric Mass Tagged Affinity Characterization (IMTAC™) platform, BridGene identified two hit compounds, which effectively inhibit cMyc signaling. These inhibitors showed potent activity in reducing transcriptional function and offering a potential therapeutic strategy for cancers driven by cMyc amplification, which accounts for nearly one-third of all tumors. In addition to its work on cMyc, BridGene will present research titled "Discovery of a Novel Covalent ADAR1 Inhibitor," focusing on a novel covalent inhibitor targeting ADAR1, an enzyme that plays a critical role in RNA editing and immune suppression in cancer. By inhibiting ADAR1, BridGene's compounds, could be expected to enhance the efficacy of immune checkpoint blockade therapies. This research highlights the potential for ADAR1 inhibitors to reshape the tumor microenvironment, paving the way for more effective immunotherapies. BridGene's third poster presentation, "Discovery of a Novel Covalent PAX8 Inhibitor," will unveil a covalent inhibitor of PAX8, a transcription factor linked to poor prognosis in renal cell carcinoma and ovarian cancer. Utilizing its IMTAC™ platform, BridGene discovered a compound that disrupts the DNA binding activity of PAX8. This discovery opens the door to new therapeutic strategies for cancers with elevated PAX8 expression, which have traditionally been difficult to target. About BridGene Biosciences BridGene is a biotechnology company focused on discovering and developing innovative small molecules that drug traditionally undruggable targets, providing new paths to treat diseases. By using its proprietary chemoproteomic platform, IMTAC™, BridGene can screen small molecules against all proteins in live cells to discover drug candidates for high-value and previously undruggable targets. BridGene is advancing a diversified pipeline of first-in-class drugs for targets in multiple disease areas. For more information, visit . Contact Tiberend Strategic Advisors, Inc. Jonathan Nugent (investors) 205-566-3026 [email protected] Dave Schemelia (media) 609-468-9325 [email protected] SOURCE BridGene Biosciences WANT YOUR COMPANY'S NEWS FEATURED ON PRNEWSWIRE.COM? 440k+ Newsrooms & Influencers 9k+ Digital Media Outlets 270k+ Journalists Opted In GET STARTED

Annual award honors exceptional Colorado leaders living their legacy DENVER, Nov. 30, 2023 /PRNewswire/ -- This year's honorees for the Colorado Governor's Citizenship Medals were announced by Governor Jared Polis in partnership with CiviCO, the state's premier nonprofit leadership development organization. The medals are bestowed upon citizens and organizations who inspire excellence and service. 2023's six recipients will be honored with a dedicated ceremony on January 25, 2024 at History Colorado Center as part of Colorado Leadership Month. The 2023 recipients and categories and link to photos: John Fielder, Photographer — Colorado Mountain Leader Award (posthumous) Dr. Carlotta Walls LaNier, Civil Rights Leader — Vanguard Legacy Medal John Street, CEO and co-founder, PAX8 — Growth and Innovation Medal Lauren Young Casteel, President and CEO, The Women's Foundation of Colorado— Public and Community Service Medal Osvaldo Garcia Barron, Student — Emerging Community Leader Medal Steamboat Ski and Resort Corporation, Rob Perlman, President and COO — Corporate Citizenship Medal The medals, established in 2015, and inspired by the Presidential Medal of Freedom, represent the highest honor recognizing each recipient's significant contributions to communities across Colorado. Nominating partners cultivate a list of community leaders, which are presented to the Governor for his final selection process. Each of the 2023 medal recipients share the distinct quality of living their legacies through their life's work. "Each year, it is an honor to award the Governor's Citizenship medals and celebrate the incredible people, organizations, nonprofits, and businesses, committed to bettering Colorado, " said Governor Jared Polis. "The six recipients selected this year have gone above and beyond in their commitment to our state. On behalf of all Coloradans, I thank those being honored for working to make Colorado a great place to live and inspiring others to do the same." "This year's medal recipients are bold leaders who lived their legacy," said Ryan Heckman, chairman of CiviCO. "It is an honor to partner with Governor Polis and former governors to celebrate the power of leadership and recognize the enduring and powerful impact these award honorees have made and continue to make in Colorado." Ticket and sponsorship opportunities for the medal ceremony are limited. Please visit for more information. SOURCE CiviCO

DENVER, March 19, 2021 (GLOBE NEWSWIRE) -- Pax8, the best place for IT professionals to buy cloud products, today announced it has been honored with three 2021 XCellence awards for Best in Show, XCellence in Keynote Presentation, and XCellence in Booth Strategy at this year’s XChange+ hybrid conference, hosted by The Channel Company. The XChange+ hybrid conference unites remote live events with an interactive virtual experience. “With the cloud technology market expected to experience hyper-growth in 2021, we are dedicated to enabling our partners with the capabilities to capitalize on the latest opportunities,” said Ryan Walsh, Channel Chief and Chief Product Officer at Pax8. “Pax8 continues developing advanced technologies and providing innovative solutions, empowering our partners to grow and succeed in the modern channel. Thank you to the XChange community for their vote and trust in Pax8.” Pax8 was selected for this award by leading solution providers attending the XChange+ conference in appreciation of its innovative products, services and partner programs. This award recognizes Pax8’s exceptional commitment to helping solution providers meet the needs of their customers in even the most challenging of times. “Our innovative XChange+ hybrid conference delivered the core elements that are at the heart of our IT channel events and attracted the industry’s elite technology vendors. The hybrid event provided the ideal format for vendors to showcase their technology solutions and programs specifically designed to enable solution providers to accelerate their business,” said Bill Jones, Senior Vice President and General Manager, Events at The Channel Company. “Through their products, programs and services, these vendors exhibited their unwavering commitment to helping solution providers find new growth paths in 2021 and capitalize on the business lessons learned over the past year. We congratulate Pax8 and thank all the recipients of 2021 XCellence Awards for their valuable contributions to the IT channel.” The Channel Company’s XChange+ hybrid conference was held from March 8-11, with three remote live events taking place between March 8-10 and a virtual experience on March 11. XChange+ provides attendees with empowering insight, actionable business intelligence and unmatched connections through strategic thought leadership, interactive boardroom appointments, peer-to-peer breakout sessions and networking time, and access to leading tech vendors in the Solutions Pavilion. Attendees learn from industry leaders, who present the latest technologies, programs and business models that are profoundly impacting the channel landscape. To view the full list of 2021 XChange+ XCellence Award winners, visit: To learn more about Pax8, please visit . About Pax8 Pax8 is modernizing how partners buy, sell, and manage cloud. As a born-in-the-cloud company, Pax8 simplifies the buying journey, empowering its partners to achieve more with cloud technology. The company’s technology displaces legacy distribution by connecting the channel ecosystem to its award-winning transactional cloud marketplace. Through billing, provisioning, automation, industry-leading PSA integrations, and pre and post-sales support, and education, Pax8 is a proven disruptor in the market. Pax8 has ranked in the Inc. 5000 for three consecutive years — #68 in 2018, #60 in 2019, and #111 in 2020 — as one of the fastest-growing private companies in the US. If you want to be successful with cloud, you want to work with Pax8. Get started today at . Follow Pax8 on Facebook, LinkedIn, and Twitter. About The Channel Company The Channel Company enables breakthrough IT channel performance with our dominant media, engaging events, expert consulting and education, and innovative marketing services and platforms. As The Channel Catalyst, we connect and empower technology suppliers, solution providers and end users. Backed by more than 30 years of unequalled channel experience, we draw from our deep knowledge to envision innovative new solutions for ever-evolving challenges in the technology marketplace. Follow The Channel Company: Twitter, LinkedIn, and Facebook. Media contact: John Trent PR Manager at Pax8 jtrent@pax8.com