Request Demo

Last update 23 Jan 2025

ROMO1

Last update 23 Jan 2025

Basic Info

Synonyms

bA353C18.2, C20orf52, Epididymis tissue protein Li 175

+ [8]

Introduction

Induces production of reactive oxygen species (ROS) which are necessary for cell proliferation. May play a role in inducing oxidative DNA damage and replicative senescence. May play a role in the coordination of mitochondrial morphology and cell proliferation. Has antibacterial activity against a variety of bacteria including S.aureus, P.aeruginosa and M.tuberculosis. Acts by inducing bacterial membrane breakage.

Drugs associated with ROMO1

SUL-121

Target

ROMO1

Mechanism

ROMO1 inhibitors

Active Org.

University of Manitoba [+3]

Originator Org.

Sulfateq BV

Active Indication

Diabetic Nephropathies [+1]

Inactive Indication-

Drug Highest PhasePreclinical

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

PER-3

Target

ROMO1

Mechanism

ROMO1 inhibitors

Active Org.-

Originator Org.

Peroxitech Therapeutics, Inc.

Active Indication-

Inactive Indication

Acute Lung Injury [+2]

Drug Highest PhaseDiscontinued

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

PER-002

Target

ROMO1

Mechanism

ROMO1 modulators

Active Org.-

Originator Org.

Peroxitech Therapeutics, Inc.

Active Indication-

Inactive Indication

Acute Lung Injury

Drug Highest PhasePending

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

Clinical Trials associated with ROMO1

NCT02383992

/ WithdrawnNot ApplicableIIT

Comparing the Efficacy of Hydrogen Peroxide Versus Normal Saline in Postoperative Care of Sutured Wounds

The primary objective of this study is to compare the efficacy of hydrogen peroxide versus normal saline in postoperative care of sutured wounds. Subjects will be randomly assigned to standard of care hydrogen peroxide or standard of care normal saline in postoperative care of sutured wounds followed by applying petroleum jelly and sterile gauze bandage. Data will be collected at day 0 and between days 7 to14. Subjects will provide irritation scale rating (0-4) with 0 being none/absent and 4 being severe/extreme.

Start Date01 Oct 2015

Sponsor / Collaborator

Northwestern University

100 Clinical Results associated with ROMO1

100 Translational Medicine associated with ROMO1

0 Patents (Medical) associated with ROMO1

142

Literatures (Medical) associated with ROMO1

01 Dec 2024·Aquatic Toxicology

Integrated physiological, energy metabolism, and metabonomic responses indicate the stress response in the hepatopancreas of Litopenaeus vannamei to nitrite stress

Article

Author: Nan, Yuxiu ; Wang, Yun ; Xiao, Meng ; Yang, Yukai ; Duan, Yafei ; Zhong, Guowei

Nitrite is a toxic substance found in rearing water that affects shrimp health. The hepatopancreas is an important digestive, immune, and metabolic organ in the shrimp. In this study, shrimps (Litopenaeus vannamei) were separately exposed to 1 and 5 mg/L nitrite stress for 48 h, and the toxicity of nitrite in the hepatopancreas was explored by integrating histology, physiological indicators, energy metabolism, and metabolomics. Nitrite stress induced morphological changes and stress responses in the hepatopancreas. Specifically, physiology-related indices, such as the relative gene expression levels of antioxidants (ROMO1, Nrf2, GPx), endoplasmic reticulum stress (Bip, IRE1 and XBP1), and immune genes (ALF, Pen-3, Lys) were decreased, whereas the gene expression of apoptosis (Casp-3), detoxification (CYP450), and glutamic oxaloacetic transaminase (GOT) activity were increased. The activities of osmotic adjustment-related enzymes (NKA, CMA, and ATPase) also decreased. Energy metabolism-related indices, such as pyruvate and hepatic glycogen contents, increased, whereas glucose, lactic acid, triglyceride, and ATP contents and ATPase activity decreased, and the relative gene expression levels of carbohydrate metabolism (PDH, HK, and LDH) and electron-transport chain genes (CytC, COI and CCO) decreased, and the expressions of lipid metabolism (AMPK, SREBP, and FAS), tricarboxylic acid cycle (MDH, CS, IDH and FH) genes were also disturbed. The metabolic pattern of the hepatopancreas was affected by nitrite stress. Glycine, serine, and threonine metabolism were highly affected, and more functional amino acids varied in the 5 mg/L nitrite stress group. These results reveal the toxic effects of nitrite stress on the stress response, physiology, energy metabolism, and metabolite homeostasis in the hepatopancreas of shrimp. Several potential metabolite biomarker candidates were identified for toxicological evaluation.

01 Dec 2024·Poultry Science

Oleanolic acid improves antioxidant capacity and the abundance of Faecalibacterium prausnitzii in the intestine of broilers

Article

Author: Kang, Mingxuan ; Xue, Chenyu ; Dong, Na ; Zhao, Qianwen ; Tu, Jianing ; Bi, Chongpeng

This study investigated the effect of dietary oleanolic acid (OA) addition on broiler intestinal morphology, intestinal antioxidant capacity, changes in cecum microbiota, and the relationship between microbiota and antioxidant capacity. A total of 288 Arbor Acres broilers at 1-day-old broilers were reared, and they were randomly divided into four groups. The control and experimental groups were fed the basal diet and the basal diet supplemented with 50, 100, and 150 mg/kg OA for a total of 42 d respectively. The results showed that OA does not affect the performance of broiler chickens. The OA supplementation increased the ratio between jejunum villus height and crypt depth (P < 0.05). The expression of antioxidant enzymes (GSH-PX and CAT) and antioxidant-related genes (HO-1, NQO1, Nrf2, and CAT) was significantly increased in the jejunum and cecum (P < 0.05). In addition, jejunal T-AOC activity (P < 0.05) and cecum antioxidant-related gene GPX-1 expression (P < 0.01) were significantly increased. The expression of oxidation-related genes (NOX and ROMO1) was significantly down-regulated in both jejunum and cecum (P < 0.05). The addition of 150 mg/kg of OA increased the relative abundance of potentially beneficial bacteria and Faecalibacterium prausnitzii was significantly and positively correlated with the expression levels of antioxidant-related genes. In conclusion, the addition of OA to the diet may improve the intestinal antioxidant capacity and modulate the intestinal microbiota of broilers. Moreover, OA improved intestinal antioxidant capacity by increasing the relative abundance of F. prausnitzii.

01 Oct 2024·FEBS Open Bio

Structure prediction analysis of human core TIM23 complex reveals conservation of the protein translocation mechanism

Article

Author: Draczkowski, Piotr ; Maruszczak, Klaudia K. ; Wnorowski, Artur ; Chacinska, Agnieszka

The majority of mitochondrial proteins are encoded in the nucleus, translated on cytosolic ribosomes, and subsequently targeted to the mitochondrial surface. Their further import into the organelle is facilitated by highly specialized protein translocases. Mitochondrial precursor proteins that are destined to the mitochondrial matrix and, to some extent, the inner membrane, utilize translocase of the inner membrane (TIM23). This indispensable import machinery has been extensively studied in yeast. The translocating unit of the TIM23 complex in yeast consists of two membrane proteins, Tim17 and Tim23. In contrast to previous findings, recent reports demonstrate the primary role of Tim17, rather than Tim23, in the translocation of newly synthesized proteins. Very little is known about human TIM23 translocase. Human cells have two orthologs of yeast Tim17, TIMM17A and TIMM17B. Here, using computational tools, we present the architecture of human core TIM23 variants with either TIMM17A or TIMM17B, forming two populations of highly similar complexes. The structures reveal high conservation of the core TIM23 complex between human and yeast. Interestingly, both TIMM17A and TIMM17B variants interact with TIMM23 and reactive oxygen species modulator 1 (ROMO1); a homolog of yeast Mgr2, a protein that can create a channel‐like structure with Tim17. The high structural conservation of proteins that form the core TIM23 complex in yeast and humans raises an interesting question about mechanistic and functional differences that justify existence of the two variants of TIM23 in higher eukaryotes.

Analysis

Perform a panoramic analysis of this field.

view full example data

Chat with Hiro

Get started for free today!

Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.

Start your data trial now!

Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.

Bio

Bio Sequences Search & Analysis

Chemical

Chemical Structures Search & Analysis

ROMO1

Basic Info

Related

Analysis