NR4A1

Preclinical Data Published in the Peer-Reviewed Journal of Medicinal Chemistry Identifies Vidofludimus Calcium as a Potent Nurr1 Activator Nurr1 Activation Suggested to Prevent Neurodegeneration Which is Relevant in Multiple Sclerosis, Parkinson's Disease and Beyond NEW YORK, May 17, 2023 /PRNewswire/ -- Immunic, Inc. (Nasdaq: IMUX), a biotechnology company developing a clinical pipeline of orally administered, small molecule therapies for chronic inflammatory and autoimmune diseases, today announced the publication of preclinical data confirming that vidofludimus calcium (IMU-838) acts as a potent nuclear receptor related 1 (Nurr1) activator, in addition to its known mode of action as a dihydroorotate dehydrogenase (DHODH) inhibitor. Activation of Nurr1 could be responsible for the drug's postulated neuroprotective effects and may contribute to the previously reported reduction of confirmed disability worsening events in multiple sclerosis patients. Specifically, preclinical data shows potent Nurr1 activation by vidofludimus calcium at low concentrations in several test systems. The data was published in the peer-reviewed, high impact Journal of Medicinal Chemistry, in a paper entitled, "Development of a potent Nurr1 agonist tool for in vivo applications." Nurr1 is a neuroprotective transcription factor and an emerging target in neurodegenerative diseases. Immunic, together with its collaboration partner at Ludwig-Maximilians-University Munich, has discovered in preclinical testing strong, meaningful Nurr1 activation by vidofludimus calcium and a range of derivative compounds in Immunic's portfolio. In addition, vidofludimus calcium has shown preference over the highly related receptors Nur77 and NOR-1. Prof. Dr. Daniel Merk, Chair of Pharmaceutical and Medicinal Chemistry, Department of Pharmacy, Ludwig-Maximilians-University Munich, commented, "Nurr1 has been identified as a promising target for neuroprotection in diseases such as multiple sclerosis or Parkinson's disease. However, there has been a lack of potent and selective Nurr1 agonists for sufficient target validation. From what we have now seen in our preclinical models, vidofludimus calcium and structurally related molecules are among the most potent Nurr1 agonists in literature." "The neuroprotective characteristics of Nurr1 suggest broad therapeutic potential for pharmacological activation of this transcription factor in neurodegenerative pathologies. In preclinical testing, we have discovered strong Nurr1 agonism by vidofludimus calcium," stated Hella Kohlhof, Ph.D., Chief Scientific Officer of Immunic. "The neuroprotective properties of vidofludimus calcium were already identified in our phase 2 EMPhASIS trial in patients with relapsing-remitting multiple sclerosis, where the trial data showed encouraging clinical signals regarding prevention of confirmed disability worsening as well as a remarkable reduction of the biomarker neurofilament light chain (NfL)." "The preclinical data confirming vidofludimus calcium as a potent Nurr1 activator is another exciting milestone for our lead development program as it suggests that Nurr1 may be responsible for the drug's postulated neuroprotective effects," added Daniel Vitt, Ph.D., Chief Executive Officer and President of Immunic. "With this data, we have also taken steps to strengthen our intellectual property position with the submission of a new patent application in the United States and European Union. Importantly, our ongoing phase 2 CALLIPER trial in progressive multiple sclerosis is designed to further corroborate the neuroprotective potential of vidofludimus calcium in a progressive patient population, for which we expect to report an interim analysis providing selected biomarker data, including serum NfL and glial fibrillary acidic protein (GFAP), in the second half of this year." About Vidofludimus Calcium (IMU-838) Vidofludimus calcium is a small molecule investigational drug in development as an oral next-generation treatment option for patients with multiple sclerosis and other chronic inflammatory and autoimmune diseases. The selective immune modulator is a known inhibitor of the enzyme dihydroorotate dehydrogenase (DHODH), which is a key enzyme in the metabolism of overactive immune cells and virus-infected cells. This mechanism is associated with the anti-inflammatory and anti-viral effects of vidofludimus calcium. Additionally, vidofludimus calcium activates the neuroprotective transcription factor nuclear receptor related 1 (Nurr1), which is associated with direct neuroprotective properties. Vidofludimus calcium has been observed to selectively act on hyperactive T and B cells while leaving other immune cells largely unaffected and enabling normal immune system function, e.g., in fighting infections. To date, vidofludimus calcium has been tested in more than 1,400 individuals and has shown an attractive pharmacokinetic, safety and tolerability profile. Vidofludimus calcium is not yet licensed or approved in any country. About Immunic, Inc. Immunic, Inc. (Nasdaq: IMUX) is a biotechnology company developing a clinical pipeline of orally administered, small molecule therapies for chronic inflammatory and autoimmune diseases. The company's lead development program, vidofludimus calcium (IMU-838), currently in phase 3 clinical trials for the treatment of multiple sclerosis and which has shown therapeutic activity in phase 2 clinical trials in patients suffering from relapsing-remitting multiple sclerosis and moderate-to-severe ulcerative colitis, selectively inhibits activated immune cells and shows combined anti-inflammatory, anti-viral and neuroprotective effects. IMU-856 is targeted to restore intestinal barrier function and regenerate bowel epithelium, which would be applicable in numerous gastrointestinal diseases, such as celiac disease, where it is currently in preparations for a phase 2 clinical trial. For further information, please visit: . Cautionary Statement Regarding Forward-Looking Statements This press release contains "forward-looking statements" that involve substantial risks and uncertainties for purposes of the safe harbor provided by the Private Securities Litigation Reform Act of 1995. All statements, other than statements of historical facts, included in this press release regarding strategy, future operations, future financial position, future revenue, projected expenses, sufficiency of cash, expected development, timing and results of clinical trials, prospects, plans and objectives of management are forward-looking statements. Examples of such statements include, but are not limited to, statements relating to Immunic's development programs and the targeted diseases; the potential for vidofludimus calcium to safely and effectively target diseases; preclinical and clinical data for vidofludimus calcium; the timing of current and future clinical trials and anticipated clinical milestones; the nature, strategy and focus of the company and further updates with respect thereto; and the development and commercial potential of any product candidates of the company. Immunic may not actually achieve the plans, carry out the intentions or meet the expectations or projections disclosed in the forward-looking statements and you should not place undue reliance on these forward-looking statements. Such statements are based on management's current expectations and involve substantial risks and uncertainties. Actual results and performance could differ materially from those projected in the forward-looking statements as a result of many factors, including, without limitation, the COVID-19 pandemic, increasing inflation, impacts of the Ukraine – Russia conflict on planned and ongoing clinical trials, risks and uncertainties associated with the ability to project future cash utilization and reserves needed for contingent future liabilities and business operations, the availability of sufficient financial and other resources to meet business objectives and operational requirements, the fact that the results of earlier preclinical studies and clinical trials may not be predictive of future clinical trial results, the protection and market exclusivity provided by Immunic's intellectual property, risks related to the drug development and the regulatory approval process and the impact of competitive products and technological changes. A further list and descriptions of these risks, uncertainties and other factors can be found in the section captioned "Risk Factors," in the company's Annual Report on Form 10-K for the fiscal year ended December 31, 2022, filed with the SEC on February 23, 2023, and in the company's subsequent filings with the Securities and Exchange Commission. Copies of these filings are available online at or ir.imux.com/sec-filings. Any forward-looking statement made in this release speaks only as of the date of this release. Immunic disclaims any intent or obligation to update these forward-looking statements to reflect events or circumstances that exist after the date on which they were made. Immunic expressly disclaims all liability in respect to actions taken or not taken based on any or all the contents of this press release. Contact Information Immunic, Inc. Jessica Breu Head of Investor Relations and Communications +49 89 2080 477 09 jessica.breu@imux.com US IR Contact Rx Communications Group Paula Schwartz +1 917 633 7790 immunic@rxir.com US Media Contact KOGS Communication Edna Kaplan +1 617 974 8659 kaplan@kogspr.com View original content to download multimedia: SOURCE Immunic, Inc. Company Codes: NASDAQ-NMS:IMUX

Company progressing with plans to focus on its RNA business Advancing discussions for divestiture or spin-off of legacy assets, including BentrioTM and AM-125 nasal sprays Bentrio revenues were $1.3 million in first half of 2022 HAMILTON, Bermuda, Aug. 30, 2022 (GLOBE NEWSWIRE) -- Altamira Therapeutics Ltd. (NASDAQ:CYTO), a company dedicated to developing therapeutics that address important unmet medical needs, today provided a business update on its strategic repositioning and key developments in its business. “We continue to be on track with our plan to refocus the Company around our exciting RNA delivery platform and to divest or spin off our legacy business to unlock the intrinsic value of our assets,” commented Thomas Meyer, the Company’s founder, CEO and Chairman. “Over the past few months, we made great progress in raising awareness of our patented OligoPhore / SemaPhore technology for efficient and safe RNA delivery to extrahepatic target tissues. “In addition, we reached important milestones with our nasal spray programs, Bentrio and AM-125, obtaining positive study data for both as well as regulatory clearance for Bentrio in the US and elsewhere. We are making good progress in our efforts to partner both programs, on which we have spent approximately $15 million and $18 million, respectively, to date.” Altamira expects to report its first-half 2022 financial results in early October 2022. Preliminary figures show that the Company recorded revenues related to Bentrio of $1.3 million during that period. LeveragingBentrio’s commercial potential in US and Europe through partnering As previously announced, Altamira’s strategy is to commercialize Bentrio globally through well-established OTC consumer health companies with a strong footprint in the respiratory health market, respectively the “allergy” and “cough and cold” categories. While the Company has already established distribution agreements with partners covering most of the important Asian markets except Japan, and the Middle East, the Company’s current partnering activities are focusing on the US, EU and other key international markets. Since receiving 510(k) clearance from the US Food and Drug Administration (FDA) for marketing Bentrio Allergy Blocker, Altamira has advanced partnering discussions with a number of interested parties in a structured process. In this context, the Company has suspended preparations for launching the product in the US on its own as well as major market initiatives in Europe. The US and Europe together represent the largest OTC markets worldwide by far. Major potential in allergy management… One of the key indications for Bentrio is the treatment of mild to moderate allergic rhinitis. In the US, 7.8% of people over 18 have hay fever,1 and the market for OTC allergy medicines was $4 billion in 2020.2 Traditionally, allergy management has been based on treatment with antihistamine or corticosteroid drugs and the use of decongestants to address nasal inflammation and the classic symptoms of nasal congestion, sneezing, nasal itching, and rhinorrhea. Among drug-free options, which have been growing in importance, saline nasal sprays are used for rinsing allergen particles off the nasal cavity. Bentrio as a drug-free and preservative-free nasal spray is designed to protect allergy sufferers by forming a mucous-like gel barrier that coats the nasal membranes for several hours, trapping inhaled allergens within the nasal cavity and helping with their clearance via the digestive tract. Bentrio’s protective effects have already been demonstrated clinically with controlled exposure to house dust mites and grass pollen in allergen challenge chambers for 3 to 4 hours. A larger clinical trial comparing Bentrio with a seawater nasal spray (the “NASAR” study) in Australia under “everyday conditions” over 14 days was started in 2021. Positive interim safety and efficacy data from the trial helped to support the successful 510(k) application to the FDA. NASAR is expected to resume enrollment with the upcoming start of the allergy season and to complete the enrollment target of 100 patients for a read-out in Q1 2023. … and in viral infection prevention and treatment The second key indication for Bentrio is the protection against airborne viral particles. COVID-19 dramatically raised peoples’ awareness of the risk of viral infections and has created a heightened interest in, and demand for, protection. Human rhinovirus (HRV) is the most common cause of upper respiratory tract infection, and influenza resulted in 9-45 million illnesses, 140,000-810,000 hospitalizations and 12,000-61,000 deaths annually since 2010.3 US revenues for cold and cough remedies in 2021 were more than $12 billion.4 Bentrio has been successfully tested on human nasal epithelium cells for protection against SARS-CoV-2, H1N1 influenza and, most recently, HRV. Bentrio’s mode of action is the same regardless of whether it shall provide a barrier against airborne virus or allergen particles. Altamira considers that the spray can also help to reduce the viral load in the nose and the risk of viral infection. However, certain countries and regions require specifically clinical performance data to clear Bentrio for this indication, in particular related to COVID-19. In this context, the Company recently stopped marketing Bentrio in the viral infection indication in the EU and Switzerland and will re-introduce the product in the coming weeks with a labeling for allergy only. COVAMID is a randomized, placebo-controlled clinical trial to evaluate the safety, tolerability, and efficacy of Bentrio in the treatment of acute COVID-19. It began enrolling patients in March 2022. Following a blinded interim analysis, Altamira recently announced that the trial will add 24 patients bringing the total to 160, with top-line data expected in Q4 2022. The Company expects the trial to be essential for supporting its plans to expand Bentrio’s product label to include viral infections in those countries and regions requesting such data. AM-125 moving towards IND filing In June 2022, the Company announced key results from its TRAVERS phase 2 trial with AM-125, a nasal spray with betahistine as active ingredient for the treatment of vertigo. The trial enrolled a total of 124 patients who suffered from acute vestibular syndrome (AVS) following surgery for the removal of a tumor growing behind the inner ear. TRAVERS demonstrated good safety and tolerability of AM-125 at doses up to 20 mg administered three times daily for four weeks. Further, administration of AM-125 resulted in a dose- and time-dependent improvement in balance and vestibular function. On the primary efficacy endpoint, the improvement in the "Tandem Romberg" balance test, the trial showed a statistically significant increase in the time to failure (i.e. for how long balance could be maintained) for the 20 mg dose over placebo. TRAVERS thus served as proof of concept for AM-125 acting as a vestibular stimulant and helping patients to ‘get back on their feet’ more quickly. Following further analyses of the TRAVERS outcomes, the study team has been drafting an article for publication in a scientific journal. Meanwhile, the Company has been working to move the AM-125 development program forward. Altamira is planning to Investigational New Drug (IND) application with the FDA in Q4 2022, which will include the protocol for the next clinical trial with AM-125. Benefitting from its intranasal administration route, AM-125 can achieve significantly higher betahistine concentrations in blood plasma than those obtained with the currently available tablets for oral administration. Globally, there has been a dearth of innovation for treating vertigo for decades. In the context of its strategic repositioning, Altamira has initiated partnering discussions on AM-125 with a number of interested parties. Increasing recognition of our RNA delivery platform Within its new RNA business, Altamira has continued to make great progress in development and in building awareness around its patented peptide-based platforms for RNA delivery to extrahepatic tissues. The Company recently announced the launch of AM-411 for the treatment of rheumatoid arthritis (RA), the second largest therapeutic area after oncology. This second program follows AM-401 for the treatment of KRAS-driven tumors and is built on its patented OligoPhore™ delivery platform and siRNA targeting NF-kB (p65), a key checkpoint in RA inflammation. AM-411 has already been shown to potently suppress early inflammatory arthritis in a collagen antibody-induced arthritis mouse model.5 The Company intends to develop both AM-401 and AM-411 with the objective of out-licensing the drug products at a later stage. Altamira’s RNA delivery platforms OligoPhore / SemaPhore™ are increasingly being recognized for their ability to deliver RNA payloads to tissues outside the liver which are challenging to reach for currently available technologies such as lipid nanoparticles (LNPs). Recently, two publications in peer-reviewed journals by independent research groups presented fresh evidence for the technology’s effects and comparative advantages in areas of great unmet medical need. A study by a Korean group highlighted the benefits of cell-penetrating peptides over LNPs. In addition, this study compared eight such peptides in their ability to mediate cellular uptake and promote protein expression of mRNA in cancer cells and found Altamira’s SemaPhore to be the most efficient among the technologies tested.6 Another study by a Chinese group showed a remarkably mitigated severity of joint degeneration in a mouse model of osteoarthritis after treatment with OligoPhore-based nanoparticles comprising siRNA targeting the JMJD3 gene.7 In order to further increase awareness among research scientists and drug developers, Altamira will present its technology in a series of specialized conferences in the coming months. In addition, the Company will continue to expand its business development efforts for selective out-licensing of its delivery platforms as it becomes an RNA-focused company. About Altamira Therapeutics Altamira Therapeutics (NASDAQ:CYTO) is dedicated to developing therapeutics that address important unmet medical needs. The Company is currently active in three areas: the development of RNA therapeutics for extrahepatic therapeutic targets (OligoPhore™ / SemaPhore™ platforms; preclinical), nasal sprays for protection against airborne allergens and, where approved, viruses (Bentrio™; commercial) or for the treatment of vertigo (AM-125; post Phase 2), and the development of therapeutics for intratympanic treatment of tinnitus or hearing loss (Keyzilen® and Sonsuvi®; Phase 3). Founded in 2003, it is headquartered in Hamilton, Bermuda, with its main operations in Basel, Switzerland. For more information, visit: Forward-Looking Statements This press release may contain statements that constitute "forward-looking statements" within the meaning of Section 27A of the Securities Act of 1933 and Section 21E of the Securities Exchange Act of 1934. Forward-looking statements are statements other than historical facts and may include statements that address future operating, financial or business performance or Altamira Therapeutics' strategies or expectations. In some cases, you can identify these statements by forward-looking words such as "may", "might", "will", "should", "expects", "plans", "anticipates", "believes", "estimates", "predicts", "projects", "potential", "outlook" or "continue", or the negative of these terms or other comparable terminology. Forward-looking statements are based on management's current expectations and beliefs and involve significant risks and uncertainties that could cause actual results, developments and business decisions to differ materially from those contemplated by these statements. These risks and uncertainties include, but are not limited to, the approval and timing of commercialization of AM-301, Altamira Therapeutics' need for and ability to raise substantial additional funding to continue the development of its product candidates, the timing and conduct of clinical trials of Altamira Therapeutics' product candidates, the clinical utility of Altamira Therapeutics' product candidates, the timing or likelihood of regulatory filings and approvals, Altamira Therapeutics' intellectual property position and Altamira Therapeutics' financial position, including the impact of any future acquisitions, dispositions, partnerships, license transactions or changes to Altamira Therapeutics' capital structure, including future securities offerings. These risks and uncertainties also include, but are not limited to, those described under the caption "Risk Factors" in Altamira Therapeutics' Annual Report on Form 20-F for the year ended December 31, 2021, and in Altamira Therapeutics' other filings with the SEC, which are available free of charge on the Securities Exchange Commission's website at: . Should one or more of these risks or uncertainties materialize, or should underlying assumptions prove incorrect, actual results may vary materially from those indicated. All forward-looking statements and all subsequent written and oral forward-looking statements attributable to Altamira Therapeutics or to persons acting on behalf of Altamira Therapeutics are expressly qualified in their entirety by reference to these risks and uncertainties. You should not place undue reliance on forward-looking statements. Forward-looking statements speak only as of the date they are made, and Altamira Therapeutics does not undertake any obligation to update them in light of new information, future developments or otherwise, except as may be required under applicable law. CONTACT Investors@altamiratherapeutics.com 800-460-0183 1 National Ambulatory Medical Care Survey 2 3 Centers for Disease Control and Prevention 4 5 Zhou et al. (2014), Peptide-siRNA nanocomplexes targeting NF-κB subunit p65 suppress nascent experimental arthritis, J Clin Invest 124(10):4363-74. 6 Kim et al. (2022), The potential of cell-penetrating peptides for mRNA delivery to cancer cells, Pharmaceutics 14(6), 1271. 7 Jin et al. (2022), Histone demethylase JMJD3 downregulation protects against aberrant force-induced osteoarthritis through epigenetic control of NR4A1, Int J Oral Sci 14:34.

•Independent peer-reviewed study confirms high potential for OligoPhoreTM delivery platform in RNA-based treatments for osteoarthritis •Knock down of JMJD3 gene remarkably mitigated severity of joint degeneration in animal modelHAMILTON, BERMUDA , July 28, 2022 (GLOBE NEWSWIRE) -- Altamira Therapeutics ("Altamira" or the "Company") (NASDAQ:CYTO), a company dedicated to developing therapeutics that address important unmet medical needs, today announced the publication of a peer-reviewed article in the scientific journal International Journal of Oral Science titled, "Histone demethylase JMJD3 downregulation protects against aberrant force-induced osteoarthritis through epigenetic control of NR4A1" that covers an independently funded study evaluating novel treatment approaches for osteoarthritis (OA) conducted by a Shanghai-based research group. Study highlights The study used different approaches to downregulate the Jumonji domain-containing protein D3 (JMJD3) gene to assess whether this strategy would be beneficial for the treatment of OA. Nanoparticles comprising a siRNA targeting the JMJD3 gene, and Altamira’s peptide-based OligoPhore delivery platform (also known as “p5RHH”), were used to locally downregulate the expression of JMJD3 in a mouse model of OA. The study authors observed that, “the severity of joint degeneration was remarkably mitigated” thanks to administration of the nanoparticles and highlighted their “advantage of specifically targeting inflammation in the joint without off-target toxicities.” They propose JMJD3 inhibition – based on the OligoPhore platform – as an “innovative epigenetic therapy approach for joint diseases.” In their study, the authors pursued an epigenetic-based therapeutic approach (i.e. targeting gene regulation) to mitigate cartilage inflammation and damage in a murine model of osteoarthritis. OligoPhore was used to formulate siRNA polyplexes that inhibited chondrocyte production of a histone demethylase, JMJD3, in response to joint damage. JMJD3 is upregulated in joint injury and drives other inflammatory pathways to elicit further damage and chondrocyte programmed cell death. Injection of 2 weekly doses of OligoPhore-siRNA into the affected joint over 8 weeks significantly attenuated inflammation and preserved cartilage viability and integrity. CSO comments "The study's results confirm prior findings reporting the benefit of RNA therapeutics based on our nanoparticle delivery platform in models in rheumatoid arthritis and, now, osteoarthritis," commented Samuel Wickline, MD, Altamira Therapeutics’ Chief Scientific Officer." One of the key features of OligoPhore is the targeted delivery to inflamed tissues, making it particularly well suited for the treatment of arthritis with oligonucleotides, both in terms of efficacy and safety. "Osteoarthritis can have a significantly detrimental impact on the well-being and quality of life of patients, often over many years or even decades, yet there is still no disease-modifying treatment available,” Dr. Wickline added. “While our AM-411 program is targeting rheumatoid arthritis, we envision extending its potential use to osteoarthritis as well." Earlier this week, the Company announced the initiation of AM-411, a development program based on its proprietary OligoPhore delivery platform and siRNA targeting NF-κB, for a novel generation of rheumatoid arthritis (RA) therapeutics. Osteoarthritis to become one of the most prevalent diseases in the coming decades Osteoarthritis is a degenerative joint disease that can affect the many tissues of the joint.1 It can degrade cartilage, change bone shape and cause inflammation, resulting in pain, stiffness and loss of mobility. OA can affect any joint, but typically affects hands, knees, hips, lower back and neck. Its signs and symptoms typically show up more often in individuals over age 50, but OA can affect much younger people, too, especially those who have had a prior joint injury. There is no cure for OA, but there are ways to manage OA to minimize pain, continue physical activities, maintain a good quality of life and remain mobile. OA is by far the most common form of arthritis, affecting more than 32.5 million adults in the United States, according to the Centers for Disease Control and Prevention. The global prevalence of OA is increasing and the burden of the disease will rise.2 The medical cost of osteoarthritis in various high-income countries has been estimated to account for between 1% and 2.5% of the gross domestic product of these countries, with hip and knee joint replacements representing the major proportion of these health-care costs. About International Journal of Oral Science The International Journal of Oral Science seeks to publish all aspects of oral science and interdisciplinary fields, including basic, applied and clinical research. The Journal publishes peer-reviewed articles that describe new research results and review articles that provide succinct summaries of an area in oral science. The International Journal of Oral Science is published by Springer Nature. For more information, visit: https://www.nature.com/ijos/aims About OligoPhore OligoPhore is a versatile platform for safe and effective delivery of oligonucleotides such as siRNA (small interfering ribonucleic acid) into target cells. It is based on a proprietary 21-amino acid peptide that can engage any type of RNA in rapid self-assembly into a polyplex. The polyplex has a size, charge, and other physical features that allow it to escape hepatic clearance and thus to reach other target tissues than the liver. OligoPhore protects the RNA payload from degradation in the circulation and allows for rapid cellular uptake, while enabling pH-dependent nucleotide endosomal escape and cytoplasmic delivery. Effective delivery and positive treatment outcomes have been demonstrated in more than 10 murine models of disease for targets in the NF-κB family, various members of the ETS transcription factor family, and targets in the JNK and TAM pathways. About Altamira Therapeutics Altamira Therapeutics (NASDAQ:CYTO) is dedicated to developing therapeutics that address important unmet medical needs. The Company is currently active in three areas: the development of RNA therapeutics for extrahepatic therapeutic targets (OligoPhore™ / SemaPhore™ platforms; preclinical), nasal sprays for protection against airborne allergens and, where approved, viruses (Bentrio™; commercial) or for the treatment of vertigo (AM-125; Phase 2), and the development of therapeutics for intratympanic treatment of tinnitus or hearing loss (Keyzilen® and Sonsuvi®; Phase 3). Founded in 2003, it is headquartered in Hamilton, Bermuda, with its main operations in Basel, Switzerland. For more information, visit: https://altamiratherapeutics.com/ Forward-Looking Statements This press release may contain statements that constitute "forward-looking statements" within the meaning of Section 27A of the Securities Act of 1933 and Section 21E of the Securities Exchange Act of 1934. Forward-looking statements are statements other than historical facts and may include statements that address future operating, financial or business performance or Altamira Therapeutics' strategies or expectations. In some cases, you can identify these statements by forward-looking words such as "may", "might", "will", "should", "expects", "plans", "anticipates", "believes", "estimates", "predicts", "projects", "potential", "outlook" or "continue", or the negative of these terms or other comparable terminology. Forward-looking statements are based on management's current expectations and beliefs and involve significant risks and uncertainties that could cause actual results, developments and business decisions to differ materially from those contemplated by these statements. These risks and uncertainties include, but are not limited to, the approval and timing of commercialization of AM-301, Altamira Therapeutics' need for and ability to raise substantial additional funding to continue the development of its product candidates, the timing and conduct of clinical trials of Altamira Therapeutics' product candidates, the clinical utility of Altamira Therapeutics' product candidates, the timing or likelihood of regulatory filings and approvals, Altamira Therapeutics' intellectual property position and Altamira Therapeutics' financial position, including the impact of any future acquisitions, dispositions, partnerships, license transactions or changes to Altamira Therapeutics' capital structure, including future securities offerings. These risks and uncertainties also include, but are not limited to, those described under the caption "Risk Factors" in Altamira Therapeutics' Annual Report on Form 20-F for the year ended December 31, 2021, and in Altamira Therapeutics' other filings with the SEC, which are available free of charge on the Securities Exchange Commission's website at: www.sec.gov. Should one or more of these risks or uncertainties materialize, or should underlying assumptions prove incorrect, actual results may vary materially from those indicated. All forward-looking statements and all subsequent written and oral forward-looking statements attributable to Altamira Therapeutics or to persons acting on behalf of Altamira Therapeutics are expressly qualified in their entirety by reference to these risks and uncertainties. You should not place undue reliance on forward-looking statements. Forward-looking statements speak only as of the date they are made, and Altamira Therapeutics does not undertake any obligation to update them in light of new information, future developments or otherwise, except as may be required under applicable law. CONTACT Investors@altamiratherapeutics.com 800-460-0183 1 https://www.arthritis.org/diseases/osteoarthritis 2 Hunter DJ & Bierma-Zeinstra S (2019), Osteoarthritis, Lancet 393:1745-59.