Last update 01 Nov 2024

CEACAM7

Last update 01 Nov 2024

Basic Info

Synonyms

Carcinoembryonic antigen CGM2, Carcinoembryonic antigen-related cell adhesion molecule 7, CEA

+ [3]

Introduction-

Drugs associated with CEACAM7

TH015-01

Target

CEACAM7

Mechanism

CEACAM7 inhibitors

Active Org.

Bonentai (Shandong) Biomedical Technology Group Co., Ltd.

Originator Org.

Bonentai (Shandong) Biomedical Technology Group Co., Ltd.

Active Indication

Pancreatic Cancer

Inactive Indication-

Drug Highest PhasePreclinical

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

100 Clinical Results associated with CEACAM7

100 Translational Medicine associated with CEACAM7

0 Patents (Medical) associated with CEACAM7

Literatures (Medical) associated with CEACAM7

01 Feb 2024·Pathology - Research and Practice

Identification of miRNA, lncRNA and circRNA associated with gastric cancer metabolism through sequencing and bioinformatics analysis

Article

Author: Huang, Ningbo ; Zhu, Meng ; He, Shuixiang ; Zhang, Ning ; Zhu, Zenghui ; Ma, Jingwei ; Lu, Xinlan

Gastric cancer remains a highly prevalent malignancy worldwide with its molecular features poorly understood. To gain full insight into its genetic landscape, we performed whole-transcriptome sequencing on human tumors and adjacent non-tumors to predict the function of microRNA, long coding RNA, circular RNA, and mRNA, as well as estimate their correlation with gastric cancer characteristics through construction of ceRNA, WGCNA and PPI network. Functional enrichment analysis annotated nucleic acid binding, enzyme activity and binding related to differentially expressed miRNAs (dif-miRNAs); energy binding and enzyme binding related to dif-lncRNAs; protein binding and enzyme activity related to dif-circRNAs; protein digestion and absorption related to dif-mRNAs. The expression of key miR-135a-5p, lncRNAs-MSTRG.48856.1, ENST00000569981, MSTRG.22826.1, ENST00000564492, circRNAs-CCSER2, FNDC3B, CORO1C, FAM214A were validated by real-time PCR. The ceRNA network filtered 14 miRNAs, 30 lncRNAs, and 6 mRNA in the lncRNA-ceRNA axis and 8 miRNAs, 9 circRNAs, and 3 mRNA in the circRNA-ceRNA axis. Genes involved in ceRNA were annotated to be closely related to tumor material synthesis and metabolism. The WGCNA network filtered gene clusters related to TNM traits and extracted the hub genes CLDN10, CD177, newGene_35523, newGene_51201, CEACAM7, and newGene_46634. These genes were associated with cell proliferation, metabolism, and enzyme activity regulation. The PPI network analyzed the stable interaction relationships of the hub genes. Our research provides a valuable resource for understanding the molecular mechanisms of gastric cancer from the perspective of tumor metabolism.

01 Jan 2024·Journal of Advanced Research

CEACAM7 expression contributes to early events of pancreatic cancer

Article

Author: Haque, Shafiul ; Chauhan, Subhash C ; Dhasmana, Swati ; Dhasmana, Anupam ; Khan, Sheema ; Laskar, Partha ; Kotnala, Sudhir ; Yallapu, Murali M ; Jaggi, Meena

BACKGROUNDThe trends of pancreatic cancer (PanCa) incidence and mortality are on rising pattern, and it will be a second leading cause of cancer related deaths by 2030. Pancreatic ductal adenocarcinoma (PDAC), major form of PanCa, exhibits a grim prognosis as mortality rate is very close to the incidence rate, due to lack of early detection methods and effective therapeutic regimen. Considering this alarming unmet clinic need, our team has identified a novel oncogenic protein, carcinoembryonic antigen-related cell adhesion molecule 7 (CEACAM7), that can be useful for spotting early events of PDAC.METHODOLOGYThis study includes bioinformatics pre-screening using publicly available cancer databases followed by molecular biology techniques in PDAC progressive cell line panel and human tissues to evaluate CEACAM7 expression in early events of pancreatic cancer.RESULTSPanCa gene and protein expression analysis demonstrated the significantly higher expression of CEACAM7 in PDAC, compared to other cancers and normal pancreas. Overall survival analysis demonstrated an association between the higher expression of CEACAM7 and poor patients' prognosis with high hazard ratio. Additionally, in a performance comparison analysis CEACAM7 outperformed S100A4 in relation to PDAC. We also observed an increase of CEACAM7 in PDAC cell line panel model. However, poorly differentiated, and normal cell lines did not show any expression. Human tissue analysis also strengthened our data by showing strong and positive IHC staining in early-stage tumors.CONCLUSIONOur observations clearly cite that CEACAM7 can serve as a potential early diagnostic and/or prognostic marker of PDAC and may also potentiate the sensitivity of the existing biomarker panel of PDAC. However, further studies are warranted to determine its clinical significance.

01 Jun 2022·Journal of Microbiology, Immunology and InfectionQ2 · MEDICINE

CEACAM7 polymorphisms predict genetic predisposition to mortality in post-surgical septic shock patients

Q2 · MEDICINE

ArticleOA

Author: Gómez-Pesquera, Estefanía ; Martínez-Paz, Pedro ; Heredia-Rodríguez, María ; Pérez-García, Felipe ; Jiménez-Sousa, Maria Ángeles ; Gómez-Sánchez, Esther ; Tamayo, Eduardo ; Fernández-Rodríguez, Amanda ; Gonzalo-Benito, Hugo ; Resino, Salvador ; Lorenzo-López, Mario

We carried out a retrospective exploratory study on 173 patients who underwent major surgery and developed septic shock after surgery. Our findings suggest that CEACAM7 rs1001578, rs10409040, and rs889365 polymorphisms could influence septic shock-related death in individuals who underwent major surgery.

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CEACAM7

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