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Last update 08 May 2025

WDR6

Last update 08 May 2025

Basic Info

Synonyms

WD repeat domain 6, WD repeat-containing protein 6, WDR6

Introduction

Together with methyltransferase FTSJ1, methylates the 2'-O-ribose of nucleotides at position 34 of the tRNA anticodon loop of substrate tRNAs (PubMed:32558197, PubMed:33771871). Required for the correct positioning of the substrate tRNA for methylation (PubMed:32558197). Required to suppress amino acid starvation-induced autophagy (PubMed:22354037). Enhances the STK11/LKB1-induced cell growth suppression activity (PubMed:17216128).

Drugs associated with WDR6

XLIX

Target

WDR6

Mechanism

WDR6 inhibitors

Active Org.

Provincial Hospital Affiliated to Shandong First Medical University (Shandong Provincial Hospital)

Originator Org.

Provincial Hospital Affiliated to Shandong First Medical University (Shandong Provincial Hospital)

Active Indication

Fatty Liver

Inactive Indication-

Drug Highest PhasePreclinical

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

100 Clinical Results associated with WDR6

100 Translational Medicine associated with WDR6

0 Patents (Medical) associated with WDR6

Literatures (Medical) associated with WDR6

01 Mar 2025·Behavioural Brain Research

Investigating the shared genetic architecture between anxiety and stroke

Article

Author: Zhang, Zile ; Zhang, Yan ; Cai, Jianhui ; Zhang, Yichen ; Yuan, Raorao ; Cheng, Shiqi ; Fan, Hengyi ; Jiang, Yong'An ; Zhong, Bo ; Qin, Qian

BACKGROUNDAn epidemiological association between anxiety and stroke is well-established; however, the role of shared genetic factors remain unclear. This study aimed to investigate the shared genetic architecture between anxiety and stroke.METHODSUsing public genome-wide association study (GWAS) summary statistics of anxiety and stroke, we performed linkage disequilibrium score regression and super genetic covariance analyzer for global and local genetic correlation studies. Risk single nucleotide polymorphisms (SNPs) were identified through genome-wide association meta-analysis, multi-trait analysis of GWAS and PLINK, followed by functional mapping and annotation. Additionally, we conducted transcriptome-wide association studies to explore the relationship between genes and associated disease risk.RESULTSOur analysis revealed a significant genome-wide genetic correlation between anxiety and stroke. We also identified one previously unreported significant SNP (rs62099231), one risk loci, as well as identified three shared risk genes for anxiety and stroke (WDR6, CCDC71, NCKIPSD).CONCLUSIONOur study demonstrated a shared genetic structure between anxiety and stroke, enhancing our understanding of their pathogenesis and highlighting potential therapeutic targets.

01 Dec 2024·Molecular Biology Reports

PABPN1 functions as a predictive biomarker in colorectal carcinoma

Article

Author: Yao, Li-Qian ; Gao, Xiao-Jiao ; Yan, Pei-Ci ; Zhou, Ming-Hui ; Shi, Li-Zhou ; Liang, Zhi-Wei ; Han, Wei ; Li, Rui ; Teng, Ya-Jie ; Wang, Qing-Hua

PURPOSEPABPN1 acts as a modulator of poly(A) tail length and alternative polyadenylation. This research was aimed to explore the role of PABPN1 in colorectal cancer (CRC).METHODSPublic databases were performed to analyze expression, location, roles of prognosis and tumor immunity and interaction with RNAs and proteins of PABPN1. To investigate PABPN1 expression in tissues, 78 CRC specimens were collected to conduct IHC, and 30 pairs of frozen CRC and corresponding adjacent normal tissues were used to conduct qRT-PCR and WB. In addition, in vitro experiments were then carried out to identify the role of PABPN1 in CRC.RESULTSCompared with normal tissues, PABPN1 expression was significant higher in CRC. Its high level predicted poor outcome of CRC. Th1 and Treg had significant negative relationships not only with PABPN1 expression, but also with six molecules interacting with PABPN1, including IFT172, KIAA0895L, RECQL4, WDR6, PABPC1 and NCBP1. In addition, PABPN1 had negative relationships with quite a few immune markers, such as CSF1R, IL-10, CCL2 and so on. In cellular experiments, silencing PABPN1 inhibited proliferation and promoted apoptosis in HCT-116 CRC cells.CONCLUSIONIn summary, PABPN1 might become a novel biomarker and correlate with tumor immunity in CRC.

01 Oct 2023·Nature metabolism

Upregulation of WDR6 drives hepatic de novo lipogenesis in insulin resistance in mice.

Article

Author: Song, Yongfeng ; Zhao, Jiajun ; Xu, Jiawen ; Yao, Zhenyu ; Wang, Dawei ; Yang, Rui ; Liu, Jun ; Wu, Yingjie ; Gao, Ling ; Gong, Ying ; Niu, Shaona ; Kong, Junjie ; Shao, Shanshan ; Fu, Lili ; Zhao, Xinya ; Wang, Xuemin ; Lin, Xiaoyan ; Xu, Yunyun ; Chen, Wenbin ; Zhang, Zhenhai ; Wan, Qiang ; Xuan, Qiuhui ; Proud, Christopher G ; Guo, Honglin ; Li, Qihang ; Liu, Sijin ; Bo, Tao ; Wang, Ximing ; Wang, Qian

Under normal conditions, insulin promotes hepatic de novo lipogenesis (DNL). However, during insulin resistance (IR), when insulin signalling is blunted and accompanied by hyperinsulinaemia, the promotion of hepatic DNL continues unabated and hepatic steatosis increases. Here, we show that WD40 repeat-containing protein 6 (WDR6) promotes hepatic DNL during IR. Mechanistically, WDR6 interacts with the beta-type catalytic subunit of serine/threonine-protein phosphatase 1 (PPP1CB) to facilitate PPP1CB dephosphorylation at Thr316, which subsequently enhances fatty acid synthases transcription through DNA-dependent protein kinase and upstream stimulatory factor 1. Using molecular dynamics simulation analysis, we find a small natural compound, XLIX, that inhibits the interaction of WDR6 with PPP1CB, thus reducing DNL in IR states. Together, these results reveal WDR6 as a promising target for the treatment of hepatic steatosis.

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WDR6

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