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Last update 23 Jan 2025

GFAT

Last update 23 Jan 2025

Basic Info

Synonyms

D-fructose-6-phosphate amidotransferase 1, GFA, GFAT

+ [8]

Introduction

Controls the flux of glucose into the hexosamine pathway. Most likely involved in regulating the availability of precursors for N- and O-linked glycosylation of proteins. Regulates the circadian expression of clock genes BMAL1 and CRY1 (By similarity). Has a role in fine tuning the metabolic fluctuations of cytosolic UDP-GlcNAc and its effects on hyaluronan synthesis that occur during tissue remodeling (PubMed:26887390).

Drugs associated with GFAT

RO0509347

Target

GFAT

Mechanism

GFAT inhibitors

Active Org.

Hoffmann-La Roche, Inc.

Originator Org.

Hoffmann-La Roche, Inc.

Active Indication

Diabetes Mellitus, Type 2

Inactive Indication-

Drug Highest PhasePreclinical

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

100 Clinical Results associated with GFAT

100 Translational Medicine associated with GFAT

0 Patents (Medical) associated with GFAT

1,092

Literatures (Medical) associated with GFAT

01 Feb 2025·Bioresource Technology

Metabolic coupling of aerobic methane oxidation and short-cut nitrification and denitrification for anaerobic effluent treatment in photo-sequencing batch biofilm reactor

Article

Author: Fu, Jiachen ; Zhou, Zhongbo ; An, Xiao ; Yang, Caiyun ; Chen, Siqi ; Xiao, Yeyuan

This study explored the use of algae to supply oxygen in situ as an alternative to mechanical aeration for anaerobic effluent treatment in a photo-sequencing batch biofilm reactor (PSBBR). By establishing alternating aerobic (dissolved oxygen (DO) > 2 mg /L)/anoxic conditions (<0.5 mg-DO/L) through a 6-h off/6-h on biogas sparging cycle and continuous illumination (1500-3000 lux), the PSBBR achieved a significant ammonia removal rate of 15-25 mg N L^-1d^-1. This system demonstrated robust partial nitrification and nitrite reduction activities, coupled with aerobic methane oxidation. Metagenomic analysis revealed the enrichment of key microbial groups, including Leptolyngbyaceae, Methylocystis, Nitrosomonas and Hyphomicrobium. The key functional genes of methane (mmo, mdh, gfa, frm and fdh) and nitrogen (amo, hao, narGHI, and napAB) metabolisms were identified, while notably lacking nitrite oxidation genes. In conclusion, this study provides a promising post-treatment approach for anaerobic effluent through integrating biogas utilization with efficient nitrogen removal.

01 Jan 2025·Carbohydrate Polymers

β-Cyclodextrin-based geometrically frustrated amphiphiles as one-component, cell-specific and organ-specific nucleic acid delivery systems

Article

Author: Mellet, Carmen Ortiz ; López-Fernández, José ; Benito, Juan M ; García Fernández, José M. ; Mendicuti, Francisco ; Di Giorgio, Christophe ; Juárez-Gonzálvez, Inmaculada ; Fernández-Clavero, Carlos ; Garrido, María J. ; García Fernández, José M ; de Ilarduya, Conchita Tros ; Tros de Ilarduya, Conchita ; Rivero-Barbarroja, Gonzalo ; Garrido, María J ; Vélaz, Itziar ; Ortiz Mellet, Carmen ; Benito, Juan M.

We introduce an innovative β-cyclodextrin (βCD)-prototype for delivering nucleic acids: "geometrically frustrated amphiphiles (GFAs)." GFAs are designed with cationic centers evenly distributed across the primary O6 and secondary O2 positions of the βCD scaffold, while hydrophobic tails are anchored at the seven O3 positions. Such distribution of functional elements differs from Janus-type architectures and enlarges the capacity for accessing strictly monodisperse variants. Changes at the molecular level can then be correlated with preferred self-assembly and plasmid DNA (pDNA) co-assembly behaviors. Specifically, GFAs undergo pH-dependent transition between bilayered to monolayered vesicles or individual molecules. GFA-pDNA nanocomplexes exhibit topological and internal order characteristics that are also a function of the GFA molecular architecture. Notably, adjusting the pK_a of the cationic heads and the hydrophilic-hydrophobic balance, pupa-like arrangements implying axial alignments of GFA units flanked by quasi-parallel pDNA segments are preferred. In vitro cell transfection studies revealed remarkable differences in relative performances, which corresponded to distinct organ targeting outcomes in vivo. This allowed for preferential delivery to the liver and lung, kidney or spleen. The results collectively highlight cyclodextrin-based GFAs as a promising class of molecular vectors capable of finely tuning cell and organ transfection selectivity.

01 Dec 2024·Annals of Surgical Oncology

ASO Visual Abstract: Critical Role of Preoperative Hyperglycemia in Association with GFAT-1 Expression in Resected Pancreatic Cancer

Article

Author: Terai, Taichi ; Nagai, Minako ; Matsuo, Yasuko ; Sho, Masayuki ; Nakamura, Kota ; Doi, Shunsuke ; Sakata, Takeshi ; Kohara, Yuichiro ; Yasuda, Satoshi

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