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Last update 08 May 2025

C12orf73

Last update 08 May 2025

Basic Info

Synonyms

BR, BRAWNIN, C12orf73

+ [4]

Introduction

Required for the assembly and stability of the mitochondrial ubiquinol-cytochrome c reductase complex (complex III (CIII) or cytochrome b-c1 complex), a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain (ETC) which drives oxidative phosphorylation (PubMed:32161263). Mediates early complex III biogenesis (By similarity). Participates in regulating the levels of electron transport chain proteins, and therefore energy supply, in response to changes in energy demand (By similarity). Also required for cytochrome c oxidase complex (complex IV) assembly (PubMed:34969438).

Drugs associated with C12orf73

CN115552017

Patent Mining

Target

C12orf73

Mechanism-

Active Org.

Walking Fish Therapeutics, Inc.

Originator Org.

Walking Fish Therapeutics, Inc.

Active Indication

Cardiovascular Diseases [+3]

Inactive Indication-

Drug Highest PhaseDiscovery

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

100 Clinical Results associated with C12orf73

100 Translational Medicine associated with C12orf73

0 Patents (Medical) associated with C12orf73

2,035

Literatures (Medical) associated with C12orf73

01 Jul 2025·Biotechnology Advances

Genetic manipulations of brassinosteroid-related genes improve various agronomic traits and yield in cereals enabling new biotechnological revolution: Achievements and perspectives

Review

Author: Zolkiewicz, Karolina ; Ahmar, Sunny ; Gruszka, Damian

Brassinosteroids (BRs) are steroid phytohormones which regulate various developmental and physiological processes throughout plant life cycle, from seed development and germination, up to modulation of reproduction and senescence. Importantly, mutants defective in the BR biosynthesis or response show various degree of plant height reduction (dwarfism or semi-dwarfism). This agronomic trait is of particular importance considering that in contrast to tall cereal varieties, semi-dwarf cereal plants are more tolerant to lodging which occurs during unfavorable weather conditions and constitutes a serious threat to plant reproduction and yield. Moreover, it was shown that the BR deficiency or insensitivity lead to erect stature of cereal plants what enables increase in planting density and yield. The valuable combinations of these traits make the BR-related mutants exceptional alternatives in breeding programs. Noteworthy, BRs play a noticeable role in regulation of grain/kernel shape and size. Therefore, these crucial agronomic traits may be manipulated specifically in BR-dependent manner. Importantly, the semi-dwarf mutants have been successfully introduced into cereal breeding programs in the past, and new semi-dwarf mutants developed through application of gene editing approach have been recently reported as promising alternatives for development of novel, high-yielding cereal cultivars. This review presents a comprehensive description of genetic manipulations of the BR-related genes aimed at improvements of various agronomic traits in the major cereal crops - rice, wheat, maize, and barley. These improvements may be achieved through application of panicle- or grain-specific promoters, overexpression or gain-of-function approaches, gene silencing, and targeted gene editing.

01 Jul 2025·Bioorganic & Medicinal Chemistry Letters

Redox-responsive ferulic acid-biotin conjugate: Design, synthesis, and enhanced anticancer efficacy

Article

Author: Liu, Jianpeng ; Dai, Xiaoshuang ; Sun, Bin ; Mei, Ke ; Qiu, Neng

In this study, ferulic acid (FA) was conjugated with biotin via a disulfide bond to improve its anticancer activity. The resulting conjugate (FA-SS-Bio) was characterized by proton nuclear magnetic resonance (¹H NMR) and exhibited an amorphous structure, in contrast to the crystalline nature of FA. FA-SS-Bio demonstrated accelerated drug release under reductive and oxidative conditions. Biotinylation significantly increased cell uptake of the drug in biotin receptor (BR)-positive HeLa and MCF-7 cells, as confirmed by cellular uptake studies and molecular docking, which revealed strong biotin-BR interactions. Additionally, the cytotoxicity of FA-SS-Bio was significantly improved, with IC₅₀ values that were 2.94-fold and 2.95-fold lower than those of free FA against HeLa and MCF-7 cells, respectively. BR blockade with biotin reduced FA-SS-Bio cytotoxicity in a concentration-dependent manner, confirming biotin-mediated targeting. Apoptosis assays showed enhanced FA-induced apoptosis due to biotin and disulfide bonds. FA-SS-Bio demonstrated excellent blood compatibility, with a hemolysis rate below 0.5 %, compared to ∼1.5 % for FA. Additionally, FA-SS-Bio exhibited higher cell viability in MCF-10 A cells than in cancer cells, highlighting its favorable safety profile. These findings provide a novel perspective on the design of prodrug conjugates for improved cancer therapy.

01 Jun 2025·Plant Physiology and Biochemistry

Multi-omics reveal the molecular mechanisms of Sodium Nitrophenolate in enhancing cold tolerance through hormonal and antioxidant pathways in cucumber

Article

Author: Yan, Yan ; Yu, Xianchang ; Di, Qinghua ; Wang, Jun ; Sun, Mintao ; Zhou, Mengdi ; He, Chaoxing ; Li, Yansu

Sodium nitrophenate (CSN) enhanced cold tolerance of cucumber. However, at the omics-level, the molecular mechanism of CSN to cold stress remains unclear. Here, we found that CSN was comparable to abscisic acid and much stronger than 2, 4-epibrassinolide (EBR) in enhancing cold tolerance. RNA-seq indicated that CSN regulated the brassinolides (BR) and cytokinin (CK) synthesis in the late stage of cold stress (LS-CS). CSN reduced the source of BR synthesis, accelerated the conversion of intermediate substances to BR and the deactivation of BR. While, CSN accelerated CK synthesis and CK deactivation by cytokinin dehydrogenase. Hormone content determination showed that CSN increased BR and decreased CK contents during most time-points of cold stress. Kinds of hormone signaling genes at LS-CS were activated by CSN, which may be due to changes in BR and CK contents. CSN also enhanced the expression of 90 % phenylalanine ammonia-lyase genes, participated in phenylpropanoid biosynthesis, at LS-CS. Genes of phenylpropanoid biosynthesis pathway and hormones signal were co-expression during cold stress. The metabolome also showed that CSN participated phenylpropanoid biosynthesis at LS-CS too. However, as for lipid metabolome, CSN up-regulated anthocyanin, flavones and flavonols metabolism at the early stage of cold stress. The autumn and winter field yield test showed that CSN increase cucumber yield by approximately 17.67 % and economic income by 207.67 dollars/667 m². Collectedly, CSN may regulate lipid metabolism and hormone signaling mediated antioxidant pathways to enhance cold tolerance in the early and late stages of cold stress, respectively.

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C12orf73

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