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Last update 23 Jan 2025

C12orf73

Last update 23 Jan 2025

Basic Info

Synonyms

BR, BRAWNIN, C12orf73

+ [4]

Introduction

Required for the assembly and stability of the mitochondrial ubiquinol-cytochrome c reductase complex (complex III (CIII) or cytochrome b-c1 complex), a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain (ETC) which drives oxidative phosphorylation (PubMed:32161263). Mediates early complex III biogenesis (By similarity). Participates in regulating the levels of electron transport chain proteins, and therefore energy supply, in response to changes in energy demand (By similarity). Also required for cytochrome c oxidase complex (complex IV) assembly (PubMed:34969438).

Drugs associated with C12orf73

CN115552017

Patent Mining

Target

C12orf73

Mechanism-

Active Org.

Walking Fish Therapeutics, Inc.Startup

Originator Org.

Walking Fish Therapeutics, Inc.Startup

Active Indication

Cardiovascular Diseases [+3]

Inactive Indication-

Drug Highest PhaseDiscovery

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

100 Clinical Results associated with C12orf73

100 Translational Medicine associated with C12orf73

0 Patents (Medical) associated with C12orf73

2,037

Literatures (Medical) associated with C12orf73

01 Mar 2025·Plant Science

NcBRI1 positively regulate vascular development and promote biomass production in Neolamarckia cadamba

Article

Author: Lu, Wei ; Zhang, Jianjun ; Mao, Juan ; Huang, Mengjiao ; Wu, Huixiang ; Wang, Xiaoping ; Zhao, Zeping ; Li, Jianming ; Liu, Wenjie ; Liu, Linchuan ; Zhang, Xin

Brassinosteroids (BRs) are essential phytohormones that play a crucial role in plant growth and development. However, our understanding of BR receptors and their functions in tree species is currently limited. In this study, we looked for potential BR receptor genes in the burflower-tree (Neolamarckia cadamba) genome. We identified five candidate gene from sequence analysis and phylogenetic reconstruction. Among these genes, Neolamarckia cadamba BRASSINOSTEROID-INSENSITIVE 1 (NcBRI1) is ubiquitously expressed in all tested tissues and encodes a functional BR receptor localized to the plasma membrane. Ectopic expression of NcBRI1 in the Arabidopsis (Arabidopsis thaliana) loss-of-function BRI1 mutant bri1-5 not only rescued its growth retardation phenotype but also facilitated vascular development by reactivating BR signal transduction. Furthermore, overexpression of NcBRI1 promoted vascular formation and cell elongation in transgenic hairy roots of Neolamarckia cadamba. By contrast, microRNA-mediated knockdown of NcBRI1 resulted in delayed vascular development and smaller cells. Importantly, we found that manipulation of NcBRI1 in Neolamarckia cadamba can enhance the biomass of hairy roots. These findings highlight the critical role of NcBRI1 in BR signaling and its significant influence on vascular development and rapid growth in Neolamarckia cadamba.

01 Jan 2025·Plant Communications

Structural insights into brassinosteroid export mediated by the Arabidopsis ABC transporter ABCB1

Article

Author: Kvasnica, Miroslav ; Janssens, Hilde ; Ying, Wei ; Russinova, Eugenia ; Tan, Shutang ; Liu, Xin ; Wei, Hong ; Zhu, Heyuan ; Winne, Johan M. ; Sun, Linfeng ; Ma, Qian ; Gao, Yongxiang ; Winne, Johan M ; Friml, Jiří

Brassinosteroids (BRs) are steroidal phytohormones indispensable for plant growth, development, and responses to environmental stresses. The export of bioactive BRs to the apoplast is essential for BR signaling initiation, which requires binding of a BR molecule to the extracellular domains of the plasma membrane-localized receptor complex. We have previously shown that the Arabidopsis thaliana ATP-binding cassette (ABC) transporter ABCB19 functions as a BR exporter and, together with its close homolog ABCB1, positively regulates BR signaling. Here, we demonstrate that ABCB1 is another BR transporter. The ATP hydrolysis activity of ABCB1 can be stimulated by bioactive BRs, and its transport activity was confirmed in proteoliposomes and protoplasts. Structures of ABCB1 were determined in substrate-unbound (apo), brassinolide (BL)-bound, and ATP plus BL-bound states. In the BL-bound structure, BL is bound to the hydrophobic cavity formed by the transmembrane domain and triggers local conformational changes. Together, our data provide additional insights into ABC transporter-mediated BR export.

01 Jan 2025·The Plant Journal

Downy mildew effector HaRxL106 interacts with the transcription factor BIM1 altering plant growth, BR signaling and susceptibility to pathogens

Article

Author: Kourdova, Lucille Tihomirova ; Tamagnone, Nicolás ; Fabro, Georgina ; Bogino, Maria Florencia ; Lapegna Senz, Juan Marcos ; Romanowski, Andres ; Wirthmueller, Lennart

SUMMARYHyaloperonospora arabidopsidis (Hpa) is an oomycete pathogen that causes downy mildew disease on Arabidopsis. This obligate biotroph manipulates the homeostasis of its host plant by secreting numerous effector proteins, among which are the RxLR effectors. Identifying the host targets of effectors and understanding how their manipulation facilitates colonization of plants are key to improve plant resistance to pathogens. Here we characterize the interaction between the RxLR effector HaRxL106 and BIM1, an Arabidopsis transcription factor (TF) involved in Brassinosteroid (BR) signaling. We report that HaRxL106 interacts with BIM1 in vitro and in planta. BIM1 is required by the effector to increase the host plant susceptibility to (hemi)biotrophic pathogens, and thus can be regarded as a susceptibility factor. Mechanistically, HaRxL106 requires BIM1 to induce the transcriptional activation of BR‐responsive genes and cause alterations in plant growth patterns that phenocopy the shade avoidance syndrome. Our results support previous observations of antagonistic interactions between activation of BR signaling and suppression of plant immune responses and reveal that BIM1, a new player in this crosstalk, is manipulated by the pathogenic effector HaRxL106.

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C12orf73

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