vimentin

Patent covers proprietary method using methylation of the CCNA1 gene to help detect esophageal precancer and cancer NEW YORK, Oct. 15, 2024 /PRNewswire/ -- Lucid Diagnostics Inc. (Nasdaq: LUCD) ("Lucid" or the "Company"), a commercial-stage, cancer prevention medical diagnostics company, and subsidiary of PAVmed Inc. (Nasdaq: PAVM), today announced that it has received a Notice of Allowance from the United States Patent and Trademark Office (USPTO) for a patent application covering its proprietary method of using methylation of the cyclin-A1 (CCNA1) gene to help detect esophageal precancer and cancer, a key component of its EsoGuard® Esophageal DNA Test. "This patent strengthens the already robust intellectual property portfolio underlying our groundbreaking technologies and will provide strong protection for the CCNA1 methylation assay method which is at the heart of the EsoGuard assay," said Lishan Aklog, M.D., Lucid's Chairman and Chief Executive Officer. "The allowance validates our strategy of focusing on the laboratory methods of our assay—a strategy we will continue to aggressively pursue for other components of the assay." EsoGuard utilizes next-generation sequencing (NGS) to assess DNA methylation at 31 sites on two genes, vimentin (VIM) and cyclin-A1 (CCNA1). Such methylation has been shown to be strongly associated with conditions along the spectrum from early esophageal precancer (non-dysplastic Barrett's Esophagus or BE), to late precancer (dysplastic BE), to cancer (esophageal adenocarcinoma). Although VIM methylation had been previously associated with gastrointestinal neoplasias, the association of CCNA1 methylation with esophageal neoplasia is novel and appears to be more specific. The technology behind EsoGuard and the EsoCheck® Esophageal Cell Collection Device was developed at Case Western Reserve University (CWRU) by faculty members Sanford Markowitz, M.D., PhD, Amitabh Chak, M.D., and Joseph Willis, M.D., with the support of research funds from the National Institutes of Health (NIH) and elsewhere. Lucid holds the exclusive worldwide license to commercialize this technology. The successful transfer of the assay from the academic research laboratory and its subsequent commercialization was the result of close, ongoing collaboration between Lucid and CWRU. About Lucid Diagnostics Lucid Diagnostics Inc. is a commercial-stage, cancer prevention medical diagnostics company and subsidiary of PAVmed Inc. (Nasdaq: PAVM). Lucid is focused on the millions of patients with gastroesophageal reflux disease (GERD), also known as chronic heartburn, who are at risk of developing esophageal precancer and cancer. Lucid's EsoGuard® Esophageal DNA Test, performed on samples collected in a brief, noninvasive office procedure with its EsoCheck® Esophageal Cell Collection Device, represent the first and only commercially available tools designed with the goal of preventing cancer and cancer deaths through widespread, early detection of esophageal precancer in at-risk patients. For more information about Lucid, please visit and for more information about its parent company PAVmed, please visit . Forward-Looking Statements This press release includes forward-looking statements that involve risk and uncertainties. Forward-looking statements are any statements that are not historical facts. Such forward-looking statements, which are based upon the current beliefs and expectations of Lucid's management, are subject to risks and uncertainties, which could cause actual results to differ from the forward-looking statements. Risks and uncertainties that may cause such differences include, among other things, volatility in the price of Lucid's common stock; general economic and market conditions; the uncertainties inherent in research and development, including the cost and time required to advance Lucid's products to regulatory submission; whether regulatory authorities will be satisfied with the design of and results from Lucid's clinical and preclinical studies; whether and when Lucid's products are cleared by regulatory authorities; market acceptance of Lucid's products once cleared and commercialized; Lucid's ability to raise additional funding as needed; and other competitive developments. In addition, Lucid continues to monitor the COVID-19 pandemic and the pandemic's impact on Lucid's businesses. These factors are difficult or impossible to predict accurately and many of them are beyond Lucid's control. In addition, new risks and uncertainties may arise from time to time and are difficult to predict. For a further list and description of these and other important risks and uncertainties that may affect Lucid's future operations, see Part I, Item 1A, "Risk Factors," in Lucid's most recent Annual Report on Form 10-K filed with the Securities and Exchange Commission, as the same may be updated in Part II, Item 1A, "Risk Factors" in any Quarterly Report on Form 10-Q filed by Lucid Diagnostics after its most recent Annual Report. Lucid disclaims any intention or obligation to publicly update or revise any forward-looking statement to reflect any change in its expectations or in events, conditions, or circumstances on which those expectations may be based, or that may affect the likelihood that actual results will differ from those contained in the forward-looking statements. SOURCE Lucid Diagnostics WANT YOUR COMPANY'S NEWS FEATURED ON PRNEWSWIRE.COM? 440k+ Newsrooms & Influencers 9k+ Digital Media Outlets 270k+ Journalists Opted In GET STARTED

BORDEAUX, France--( BUSINESS WIRE )--RebrAIn, a pioneering precision neuro-surgery platform company, has recently received its second FDA 510(k) clearance for its OptimMRI software, which now includes a new machine learning model to assist in targeting the infero-lateral part of the VIM for lesioning techniques such as MRgFUS and Radiosurgery. This new software version already features FDA-cleared machine learning models for the STN and VIM regions of interest to assist in targeting Deep Brain Stimulation (DBS). RebrAIn has secured its second FDA 510(k) clearance in the past year, expanding the software's capabilities to include the infero-lateral part of the VIM. RebrAIn’s software as a medical device (SaMD) is designed to revolutionize neurosurgical target planning by combining advanced AI algorithms, trained on clinical data, with MRI sequences to provide neurosurgeons with the most optimal targets for lesioning and electrode placement. David Caumartin, CEO of RebrAIn, stated, “Our extension to US customers to better plan targets for lesioning is a significant step in RebrAIn’s growth and strategic transformation. The US market represents the largest opportunity to enable personalized targeting for neurological disorders such as Essential Tremor. The ability to offer AI clinical targeting to neurosurgical suites will open many collaborations nationwide, which today are treated with DBS and MR-guided focused ultrasound. Since our recent discussions at US congresses, it was necessary for us to offer neurosurgeons a complete service.” RebrAIn’s co-founders, Prof. Emmanuel Cuny MD and Prof. Nejib Zemzemi PhD, will be presenting on “VIM Lesions in Radiosurgery and Focused Ultrasound: Assessment of the Accuracy of Two Targeting Models Based on Machine Learning” at the World Society for Stereotactic and Functional Neurosurgery (WSSFN) biennial meeting in Chicago, IL, on September 5, 2024. “Our extension to US customers to better plan targets for lesioning is a significant step in RebrAIn’s growth and strategic transformation,” said David Caumartin, CEO of RebrAIn. “The US market is the largest, and the ability to offer AI clinical targeting will open many national collaborations.” To learn more, visit us at Booth #9 during the WSSFN meeting, check out our website www.rebrain.eu , or contact us directly. About RebrAIn RebrAIn is a France-based company that enables precise targeting for DBS and lesioning treatments for patients suffering from severe Parkinson's or essential tremor disease. Its SaaS solution helps neurosurgeons to precisely identify the target area for surgical intervention. Its novel approach uses machine learning of clinical patient data to predict the optimal treatment zone in each patient’s brain. For more information, visit www.rebrain.eu . About the World Society for Stereotactic and Functional Neurosurgery Since 1961, the WSSFN has been regularly held and continues to be a leading neurosurgery conference. At the biennial meetings, the top leaders in the field present the most recent innovations in clinical and basic research as well as new and effective ways to provide material support. Meta Description: "RebrAIn receives its second FDA 510(k) clearance for OptimMRI software, enhancing targeting in stereotactic and functional neurosurgery for Deep Brain Stimulation and lesioning techniques. The company will present VIM targeting advancements at the WSSFN congress." Tags: FDA 510(k) Clearance, Deep Brain Stimulation (DBS), Stereotactic Neurosurgery, Functional Neurosurgery, Medical Device Software, Machine Learning in Healthcare, MR-guided Focused Ultrasound (MRgFUS), Radiosurgery, Neurotechnology, WSSFN Congress, RebrAIn, Essential Tremor Treatment, AI in Healthcare, Precision Neurosurgery, Healthcare Innovations.

BRANFORD, Conn.--(BUSINESS WIRE)-- Quantum-Si Incorporated (Nasdaq: QSI) (“Quantum-Si,” “QSI” or the “Company”), The Protein Sequencing Company™, today announced presentations at two upcoming industry conferences. Gloria Sheynkman, PhD, Assistant Professor in the Department of Molecular Physiology and Biological Physics at the University of Virginia’s lab will present a poster developed in collaboration with Quantum-Si at the American Society for Mass Spectrometry (ASMS) annual meeting being held June 2-6, 2024. Dr. Brian Reed, Head of Research at Quantum-Si will present at the European Society for Human Genetics (ESHG) annual meeting being held June 1-4, 2024. Results of the study to be presented, by Natchanon Sittipongpittaya from Dr. Sheynkman’s lab at ASMS, represent the first integration of single-molecule detection methods with proteogenomics to detect proteotypic and isoform-selective peptides. Long read transcriptomics (LR-RNA-seq) revealed multiple annotated and novel isoforms (i.e., spliceforms) of vimentin, TPM1 and TPM2. Like many alternatively spliced isoforms, much of the predicted protein sequences are highly overlapping and difficult to distinguish. Additionally, TPM1 and TPM2, being closely related paralogs, also have high sequence identity (87%). Using the Platinum platform, protein sequencing distinguished isoform-specific peptides for filament proteins involved in cancer and skeletal muscle diseases. At ESHG, Dr. Reed will discuss the expanding role of Next-Generation Protein Sequencing™ (NGPS) in advancing biological research by enabling any researcher to sequence proteins in their lab. Quantum-Si’s protein sequencer, Platinum®, is a compact and affordable benchtop device that enables direct sequencing of proteins with single-amino-acid resolution using a simple workflow. NGPS is a transformative technology that enables direct interrogation of protein primary structure, post-translational modifications (PTMs), and protein isoform diversity. Presentation details are as follows: ASMS Title: Integrated sequencing of transcripts and proteins at the single molecule level to detect isoforms and proteolytic peptides in filament biomarkers Session: Proteomics: New Approaches Authors: Gloria Shenykman, PhD and Natchanon Sittipongpittaya, both of the University of Virginia and Kenneth Skinner, PhD, Quantum-Si Date and Time: June 3, 10:30 am - 12:30 pm and 1:30 - 2:30 pm PDT ESHG Title: Beyond the Genome: Unlocking Proteomic Discoveries with Quantum-Si’s Next-Generation Protein Sequencing™ Technology Presenter: Brian Reed, PhD Date and Time: Sunday, June 2, 8:30 -10:00 a.m. BST About Quantum-Si Incorporated Quantum-Si, The Protein Sequencing Company™, is focused on revolutionizing the growing field of proteomics. The Company’s suite of technologies is powered by a first-of-its-kind semiconductor chip designed to enable next-generation single-molecule protein sequencing and digitize proteomic research in order to advance drug discovery and diagnostics beyond what has been possible with DNA sequencing. Learn more at quantum-si.com or follow us on LinkedIn or X.