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Last update 08 May 2025

ADAMTS8

Last update 08 May 2025

Basic Info

Synonyms

A disintegrin and metalloproteinase with thrombospondin motifs 8, a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 8, ADAM metallopeptidase with thrombospondin type 1 motif 8

+ [8]

Introduction

Has anti-angiogenic properties.

Drugs associated with ADAMTS8

HG-1210

Target

ADAMTS8

Mechanism

ADAMTS8 gene modulators

Active Org.-

Originator Org.

Human Genome Sciences, Inc.

Active Indication-

Inactive Indication

Cardiovascular Diseases [+1]

Drug Highest PhasePending

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

100 Clinical Results associated with ADAMTS8

100 Translational Medicine associated with ADAMTS8

0 Patents (Medical) associated with ADAMTS8

Literatures (Medical) associated with ADAMTS8

01 Dec 2025·Molecular Biology Reports

STAT-3, ELK-1, and c- Jun contributes IL-6 mediated ADAMTS-8 upregulation in colorectal cancer

Article

Author: Sav, Feyza Nur ; Keskin, Saliha Derya ; Eroğlu, Kübra Paspal ; Alper, Meltem ; Köçkar, Feray ; Keleş, Yasemin

BACKGROUNDADAMTSs are extracellular matrix metalloproteinases that mainly process extracellular matrix components and closely related tumorigenesis. ADAMTS-8 is an anti-angiogenic member of the family and is dysregulated in common cancers. The tumor suppressor function of the ADAMTS-8 has been demonstrated in colorectal cancer. Although ADAMTS-8 plays a critical role in tumor progression, transcriptional regulatory features haven't been studied yet.MATERIALS AND METHODSThe human ADAMTS-8 promoter was cloned into the pMetLuc Reporter vector. Basal promoter activity and the effect of the IL-6 on ADAMTS-8 promoter activity were determined by transient transfection assays in SW480 cells. QRT-PCR and Western blot analyses assessed the impact of IL-6 on ADAMTS-8 mRNA and protein expressions. Functional binding of the specific transcription factors to the ADAMTS-8 promoter region was evaluated by ChIP qPCR and EMSA.RESULTSOur results demonstrated that the ADAMTS-8 promoter includes multiple binding sites for transcription factors that could be activated in the inflammatory pathways. IL-6 stimulation increased ADAMTS-8 promoter activity, also mRNA, and protein expressions. Pathway inhibition studies showed that IL-6-mediated induction of ADAMTS-8 was achieved through p38/MAPK, NF-κB, PI3K, and SAPK/JNK pathways. STATs, Elk-1, and c-Jun functionally bind to the ADAMTS-8 promoter region.CONCLUSIONIt can be concluded that inflammation is a strong positive regulator of the ADAMTS-8 gene.

06 Jan 2025·GigaScience

Exploring the cellular and molecular basis of murine cardiac development through spatiotemporal transcriptome sequencing

Article

Author: Shen, Xunan ; Wang, Jizheng ; Wang, Yue ; Li, Qingsong ; Kang, Jingmin ; Liu, Fuyan ; Wu, Renhua ; Liu, Jie ; Song, Lei ; Liu, Xin ; Liu, Peng ; Wang, Ninghe ; Luo, Xujiao ; Du, Lin

AbstractBackgroundSpatial transcriptomics is a powerful tool that integrates molecular data with spatial information, thereby facilitating a deeper comprehension of tissue morphology and cellular interactions. In our study, we utilized cutting-edge spatial transcriptome sequencing technology to explore the development of the mouse heart and construct a comprehensive spatiotemporal cell atlas of early murine cardiac development.ResultsThrough the analysis of this atlas, we elucidated the spatial organization of cardiac cellular lineages and their interactions during the developmental process. Notably, we observed dynamic changes in gene expression within fibroblasts and cardiomyocytes. Moreover, we identified critical genes, such as Igf2, H19, and Tcap, as well as transcription factors Tcf12 and Plagl1, which may be associated with the loss of myocardial regeneration ability during early heart development. In addition, we successfully identified marker genes, like Adamts8 and Bmp10, that can distinguish between the left and right atria.ConclusionOur study provides novel insights into murine cardiac development and offers a valuable resource for future investigations in the field of heart research, highlighting the significance of spatial transcriptomics in understanding the complex processes of organ development.

01 Oct 2024·Cell Host & Microbe

Networks of human milk microbiota are associated with host genomics, childhood asthma, and allergic sensitization

Article

Author: Stickley, Sara A. ; Turvey, Stuart E ; Zacharias, Amanda M. ; Azad, Meghan B ; Moossavi, Shirin ; Fang, Zhi Yi ; Surette, Michael G. ; Miliku, Kozeta ; Subbarao, Padmaja ; Fehr, Kelsey ; Petersen, Charisse ; Sears, Malcolm R. ; Zhang, Yang ; Simons, Elinor ; Moraes, Theo J ; Ambalavanan, Amirthagowri ; Zacharias, Amanda M ; Stickley, Sara A ; Azad, Meghan B. ; Sears, Malcolm R ; Mandhane, Piushkumar J ; Turvey, Stuart E. ; Duan, Qingling ; Mandhane, Piushkumar J. ; Moraes, Theo J. ; Surette, Michael G

The human milk microbiota (HMM) is thought to influence the long-term health of offspring. However, its role in asthma and atopy and the impact of host genomics on HMM composition remain unclear. Through the CHILD Cohort Study, we followed 885 pregnant mothers and their offspring from birth to 5 years and determined that HMM was associated with maternal genomics and prevalence of childhood asthma and allergic sensitization (atopy) among human milk-fed infants. Network analysis identified modules of correlated microbes in human milk that were associated with subsequent asthma and atopy in preschool-aged children. Moreover, reduced alpha-diversity and increased Lawsonella abundance in HMM were associated with increased prevalence of childhood atopy. Genome-wide association studies (GWASs) identified maternal genetic loci (e.g., ADAMTS8, NPR1, and COTL1) associated with HMM implicated with asthma and atopy, notably Lawsonella and alpha-diversity. Thus, our study elucidates the role of host genomics on the HMM and its potential impact on childhood asthma and atopy.

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ADAMTS8

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