Synonyms deoxyhypusine synthase, DHPS, DHS + [4] |
Introduction Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a critical lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue (PubMed:30661771). This is the first step of the post-translational modification of that lysine into an unusual amino acid residue named hypusine. Hypusination is unique to mature eIF-5A factor and is essential for its function. |
Target |
Mechanism DHPS inhibitors |
Active Org. |
Originator Org. |
Active Indication |
Inactive Indication- |
Drug Highest PhaseApproved |
First Approval Ctry. / Loc. US |
First Approval Date23 Dec 1996 |
Target |
Mechanism DHFR inhibitors [+1] |
Active Org. |
Originator Org. |
Active Indication |
Inactive Indication- |
Drug Highest PhaseApproved |
First Approval Ctry. / Loc. CN |
First Approval Date01 Jan 1994 |
Target |
Mechanism DHPS inhibitors |
Active Org. |
Originator Org. |
Active Indication |
Inactive Indication- |
Drug Highest PhaseApproved |
First Approval Ctry. / Loc. FR |
First Approval Date15 Jun 1992 |
Start Date01 Sep 2024 |
Sponsor / Collaborator |
Start Date30 Aug 2024 |
Sponsor / Collaborator- |
Start Date27 Jul 2024 |
Sponsor / Collaborator |