Request Demo

Last update 23 Jan 2025

mammaglobin-A

Last update 23 Jan 2025

Basic Info

Synonyms

Mammaglobin-1, Mammaglobin-A, MGB1

+ [5]

Introduction-

Drugs associated with mammaglobin-A

Mammaglobin A DNA vaccine(GSK)

Target

mammaglobin-A

Mechanism

mammaglobin-A modulators

Active Org.

GSK Plc

Originator Org.

GSK Plc

Active Indication

Breast Cancer

Inactive Indication-

Drug Highest PhasePhase 1

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

100 Clinical Results associated with mammaglobin-A

100 Translational Medicine associated with mammaglobin-A

0 Patents (Medical) associated with mammaglobin-A

151

Literatures (Medical) associated with mammaglobin-A

04 Nov 2024·Revista medica del Instituto Mexicano del Seguro Social

[Detection of circulating tumor cells in women with early breast cancer].

Article

Author: López-Muñoz, Eunice ; Aguilar Rojas, Arturo ; López-Valle, Miguel Ángel ; Moncada-Morales, Angélica ; Márquez-García, José Eduardo ; García-Rivera, Coral

BackgroundThere are multiple methods and biomarkers with different detection rates to circulating tumor cells (CTCs) in women with breast cancer (BC). However, to the best our knowledge, no study has been carried out to detect CTCs in women with early BC in Mexico.ObjectiveCalculate the detection rate of CTCs in peripheral blood of Mexican women with early BC by quantification of the relative expression of KRT19, MUC1 and SCGB2A2.Material and methodsObservational, longitudinal, analytical study, which included 62 Mexican women, over 18 years of age, with BC clinical stage 0, I and II. Cells with a density < 1.077 g/ml were isolated from 4 mL of peripheral blood obtained 24 h before surgery, RNAS was extracted and RT-qPCR was performed to quantify the relative expression of KRT19, MUC1 and SCGB2A2.ResultsThe diagnosis of BC was confirmed in the definitive pathological study in 59 women. 1 case (1.7%), expressed KRT19, 18 cases (30.5%) MUC1, 2 cases (3.4%) SCGB2A2, and 19 cases (32.2%) expressed at least one of the three biomarkers.ConclusionsCTCs detection rates were like those reported in other populations when MUC1 was used, but lower when KRT19 and SCGB2A2 were used. Standardization of blood sample collection and processing, as well as biomarker expression analysis, is important to reduce variability in the detection of CTCs in specific populations.

01 Jul 2024·Advanced Science

De‐nitrosylation Coordinates Appressorium Function for Infection of the Rice Blast Fungus

Article

Author: He, Wenhui ; Dong, Xiang ; Huang, Junbin ; Hu, Hong ; Ren, Zhiyong ; Qu, Zhiguang ; Qin, Mengyuan ; Chen, Xiao‐Lin ; Liu, Hao ; Zheng, Lu

AbstractAs a signaling molecule, nitric oxide (NO) regulates the development and stress response in different organisms. The major biological activity of NO is protein S‐nitrosylation, whose function in fungi remains largely unclear. Here, it is found in the rice blast fungus Magnaporthe oryzae, de‐nitrosylation process is essential for functional appressorium formation during infection. Nitrosative stress caused by excessive accumulation of NO is harmful for fungal infection. While the S‐nitrosoglutathione reductase GSNOR‐mediated de‐nitrosylation removes excess NO toxicity during appressorium formation to promote infection. Through an indoTMT switch labeling proteomics technique, 741 S‐nitrosylation sites in 483 proteins are identified. Key appressorial proteins, such as Mgb1, MagB, Sps1, Cdc42, and septins, are activated by GSNOR through de‐nitrosylation. Removing S‐nitrosylation sites of above proteins is essential for proper protein structure and appressorial function. Therefore, GSNOR‐mediated de‐nitrosylation is an essential regulator for appressorium formation. It is also shown that breaking NO homeostasis by NO donors, NO scavengers, as well as chemical inhibitor of GSNOR, shall be effective methods for fungal disease control.

01 May 2024·Asian Journal of Surgery

SCGB2A2 as a predictor of prognosis and response to immune-checkpoint blockage in metastatic triple-negative invasive breast cancer

Letter

Author: Peng, Yunsong ; Zheng, Yu

Analysis

Perform a panoramic analysis of this field.

view full example data

Chat with Hiro

Get started for free today!

Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.

Start your data trial now!

Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.

Bio

Bio Sequences Search & Analysis

Chemical

Chemical Structures Search & Analysis

mammaglobin-A

Basic Info

Related

Analysis