Request Demo

Last update 08 May 2025

caspase 3 x caspase 9 x caspase 8

Last update 08 May 2025

Basic Info

Related Targets

caspase 3caspase 9caspase 8

Drugs associated with caspase 3 x caspase 9 x caspase 8

NO-Ursodeoxycholic Acid

Target

caspase 3 x caspase 8 x caspase 9

Mechanism

caspase 3 inhibitors [+2]

Active Org.-

Originator Org.

Nicox SA

Active Indication-

Inactive Indication

Hypertension, Portal

Drug Highest PhaseDiscontinued

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

Clinical Trials associated with caspase 3 x caspase 9 x caspase 8

EUCTR2005-003483-31-ES

/ Not yet recruitingPhase 2

Eficacia y tolerabilidad preliminar del NCX-1000 oral después de repetidas administraciones a pacientes con hipertensión portal. Estudio a doble ciego con dosis creciente

Start Date17 Nov 2005

Sponsor / Collaborator-

NCT00414869

/ TerminatedPhase 2

Preliminary Efficacy And Tolerability Of Oral NCX-1000 After Repeated Administrations In Patients With Portal Hypertension: A Double-Blind Dose Escalating Study

Chronic liver diseases are often characterized by portal hypertension, a major complication involving haemodynamic changes due to increased intrahepatic vascular resistance. It has become well established that nitric oxide (NO) plays a crucial role in the haemodynamic abnormalities that develop in chronic portal hypertension.
NCX-1000 is a NO-releasing derivative of ursodeoxycholic acid that would compensate for the defective liver NO production in cirrhosis.
This study intends to demonstrate the desired therapeutic activity (reduction in portal pressure) in a small number of target patients, to assess the safety and tolerability after repeated oral administrations of NCX-1000, and to get preliminary pharmacokinetic data in this population.

Start Date01 Nov 2005

Sponsor / Collaborator

Forest Laboratories, Inc.

100 Clinical Results associated with caspase 3 x caspase 9 x caspase 8

100 Translational Medicine associated with caspase 3 x caspase 9 x caspase 8

0 Patents (Medical) associated with caspase 3 x caspase 9 x caspase 8

2,427

Literatures (Medical) associated with caspase 3 x caspase 9 x caspase 8

01 Jun 2025·Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology

Purslane leaf powder dietary supplementation rescues cadmium-induced disruption of behavior, antioxidant status, and expression of tight junction genes, in the brain of Nile tilapia (Oreochromis niloticus)

Article

Author: Ibrahim, Rowida E ; Mohamed, Amany Abdel-Rahman ; El-Murr, Abd Elhakeem ; Alhegaili, Alaa S ; Alsubaie, Nawal ; Khamis, Tarek ; Alotaibi, Badriyah S ; Abd-Elhakim, Yasmina M ; Bawahab, Ahmed Abdulwahab ; Metwally, Mohamed M M

This study examined the effects of supplementing the Nile tilapia (Oreochromis niloticus) diet with purslane (Portulaca oleracea L.) leaf powder (PLNP, 10 g/kg) on neurobehavioral performance, brain oxidative status, tight junction mRNA expression, and brain histology in fish exposed to waterborne cadmium (Cd, 50 μg /L) for 60 days. Adding PLNP to the diet ameliorated the Cd-induced decline in ingestive behavior and swimming behavior, and reversed the Cd-induced increase in aggressive behavior. The significant decrease in the non-enzymatic (reduced glutathione) and enzymatic (catalase and superoxide dismutase) brain antioxidants detected in Cd-exposed fish was eliminated by dietary PLNP. PLNP supplementation also led to a decrease in brain malondialdehyde content, which was elevated by Cd exposure. In addition, dietary PLNP increased brain acetylcholinesterase content, upregulated mRNA expression of tight junction (zo-2, claudin-4, and zo-1) and oxidative stress genes (sod-2, gpx, and nrf-2), and downregulated apoptotic genes (p53, caspase-9, caspase-8, and caspase-3) in the brain, relative to the alterations in these parameters caused by Cd exposure. Furthermore, the Cd-induced histological changes in the Nile tilapia brain were ameliorated by PLNP dietary supplementation. In light of these findings, PLNP may be a useful dietary supplement for reducing the harmful effects of Cd on the brain and behavior of Nile tilapia.

01 Apr 2025·Bioorganic Chemistry

Novel inhibitors of oncogenic Wnt/TCF-4/β-catenin signaling pathway: Design, synthesis, molecular docking studies and apoptosis inducing activity of pyrimidothiazino-, dihydropyrimidotriazepino- and 1,3,4-thiadiazolopyrimido-indole hybrids

Article

Author: Mourad, Ahmed A E ; Elmaaty, Ayman Abo ; Al-Karmalawy, Ahmed A ; Khodir, Ahmed E ; Eldehna, Wagdy M ; Hofni, Amal ; Aboubakr, Esam M ; Mourad, Mai A E

Wnt pathway is vital for survival of cancer-initiating cells. β-catenin plays a crucial role in Wnt pathway through interaction with TCF-4 to transcribe oncogenes. β-catenin activation suppresses immune cell infiltration into cancer cells and promotes resistance to chemotherapeutic drugs. In order to target Wnt/TCF-4/β-catenin pathway, a novel series of pyrimidothiazino-, dihydropyrimidotriazepino- and 1,3,4 thiadiazolopyrimido-indole hybrids were designed, synthesized and evaluated for their β-catenin/TCF-4 inhibitory and apoptotic inducing activities. Cytotoxicity of the synthesized hybrids was evaluated against HCT-116, A549 and HepG2 cell lines. Of the synthesized hybrids, 6a, 8b and 12b hybrids elicited superior cytotoxic activity compared to quercetin against the tested cell lines. These hybrids were able to significantly suppress β-catenin and its down-stream signaling target TCF-4 in a dose-dependent manner in HCT-116 cell line. They up-regulated p53, caspase-3, caspase-8, caspase-9 levels and Bax protein expression as well as down-regulated Bcl-2 protein expression. They successfully arrested cell cycle in pre-G1 phase and G0/G1 phase. The synthesized hybrids achieved efficient binding pattern in molecular docking study and have acceptable drug likeness characters.

01 Apr 2025·Food Science & Nutrition

Effects of Thyme, Cumin, and Sumac Extracts on Apoptosis and Paraptosis in Hepatocellular Carcinoma: Synergistic, Antagonistic, or Additive Properties

Article

Author: Ozturk, Nurefsan Konyaligil ; Ilgun, Selen ; Firat, Yagmur Yasar ; Kara, Ayca ; Cicek, Betul

ABSTRACTThis study evaluated the effect of single, double, and triple combined doses of sumac, thyme, and cumin extracts on apoptosis and paraptosis in the HepG2 cell line. The effect of thyme and cumin extracts was higher in proteins (mTOR, caspase‐8, caspase‐9, Bax and bcl‐2) other than caspase‐3 protein. The expression of caspase‐3 protein was higher in the sumac extract‐treated groups. The expression levels of GRP78/Bip and DDIT3/Chop proteins, which are indicators of paraptosis, did not exert a significant difference between the extracts. Even though their protein expression is different, according to MTT results, sumac and thyme extracts showed an additive effect, thyme and cumin extracts showed an antagonistic effect, sumac and cumin extracts showed a synergistic effect, and sumac, thyme, and cumin extracts showed a synergistic effect. Sumac, thyme, and cumin extracts induced cell death by causing apoptosis in HepG2 cells, and they may have a supportive impact on the treatment of hepatocellular carcinoma.

Analysis

Perform a panoramic analysis of this field.

view full example data

AI Agents Built for Biopharma Breakthroughs

Accelerate discovery. Empower decisions. Transform outcomes.

Get started for free today!

Accelerate Strategic R&D decision making with Synapse, PatSnap’s AI-powered Connected Innovation Intelligence Platform Built for Life Sciences Professionals.

Start your data trial now!

Synapse data is also accessible to external entities via APIs or data packages. Empower better decisions with the latest in pharmaceutical intelligence.

Bio

Bio Sequences Search & Analysis

Chemical

Chemical Structures Search & Analysis