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Last update 08 May 2025

PDCD2

Last update 08 May 2025

Basic Info

Synonyms

PDCD2, programmed cell death 2, Programmed cell death protein 2

+ [4]

Introduction

May be a DNA-binding protein with a regulatory function. May play an important role in cell death and/or in regulation of cell proliferation.

Drugs associated with PDCD2

10e(Stanford University)

Target

PDCD2

Mechanism

PDCD2 inhibitors

Active Org.

Stanford University [+1]

Originator Org.

Stanford University [+1]

Active Indication

Neoplasms

Inactive Indication-

Drug Highest PhasePreclinical

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

10g(Stanford University)

Target

PDCD2

Mechanism

PDCD2 inhibitors

Active Org.

Dana-Farber Cancer Institute, Inc. [+1]

Originator Org.

Stanford University [+1]

Active Indication

Neoplasms

Inactive Indication-

Drug Highest PhasePreclinical

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

10d(Stanford University)

Target

PDCD2

Mechanism

PDCD2 inhibitors

Active Org.

Stanford University [+1]

Originator Org.

Stanford University [+1]

Active Indication

Neoplasms

Inactive Indication-

Drug Highest PhasePreclinical

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

100 Clinical Results associated with PDCD2

100 Translational Medicine associated with PDCD2

0 Patents (Medical) associated with PDCD2

Literatures (Medical) associated with PDCD2

15 Apr 2025·Proceedings of the National Academy of Sciences

Biallelic variants in the conserved ribosomal protein chaperone gene PDCD2 are associated with hydrops fetalis and early pregnancy loss

Article

Author: Bachand, François ; Jeffries, Lauren ; Landry-Voyer, Anne-Marie ; Holling, Tess ; Lakhani, Saquib A. ; Mis, Emily K. ; Alawi, Malik ; Ji, Weizhen ; Kutsche, Kerstin ; Mir Hassani, Zabih

Pregnancy loss is a major problem in clinical medicine with devastating consequences for families. Next generation sequencing has improved our ability to identify underlying molecular causes, though over half of all cases lack a clear etiology. Here, we began with clinical evaluation combined with exome sequencing across independent families to identify bi-allelic candidate genetic variants in the Programmed Cell Death 2 (PDCD2) gene in multiple fetuses with nonimmune hydrops fetalis (NIHF). PDCD2 is an evolutionarily conserved protein with no prior association with monogenic disorders. PDCD2 is known to act as a molecular chaperone for the ribosomal protein uS5, and this complex formation is important for incorporation of uS5 into the 40S subunit, a crucial step in ribosome biogenesis. Primary fibroblasts from an affected fetus and cell lines expressing PDCD2 patient variants demonstrated reduced levels of PDCD2, reduced PDCD2 binding to uS5, and altered ribosomal RNA processing. Xenopus tadpoles with Pdcd2 knockdown demonstrated developmental defects and edema, reminiscent of the NIHF seen in affected fetuses, and showed altered ribosomal RNA processing. Through genetic, biochemical, and in vivo approaches, we provide evidence that bi-allelic PDCD2 variants cause an autosomal recessive ribosomal biogenesis disorder resulting in pregnancy loss.

01 Sep 2024·Genes & Diseases

PDCD2 as a prognostic biomarker in glioma correlates with malignant phenotype

Article

Author: Cheng, Xing ; Zhou, Xiangyi ; Zhou, Li ; Hao, Jiaqi ; Zhao, Yi ; Dai, Fengsheng ; Tian, Rui ; Xiang, Tingxiu ; Yuan, Yixiao

Programmed cell death 2 (PDCD2) is related to cancer progression and chemotherapy sensitivity. The role of PDCD2 in solid cancers (excluding hematopoietic malignancies) and their diagnosis and prognosis remains unclear. The TCGA, CGGA, GEPIA, cBioPortal, and GTEx databases were analyzed for expression, prognostic value, and genetic modifications of PDCD2 in cancer patients. Functional enrichment analysis, CCK8, colony formation assay, transwell assay, and xenograft tumor model were undertaken to study the PDCD2's biological function in glioma (GBMLGG). The PDCD2 gene was associated with solid cancer progression. In the functional enrichment analysis results, PDCD2 was shown to participate in several important GBMLGG biological processes. GBMLGG cells may be inhibited in their proliferation, migration, invasion, and xenograft tumor growth by knocking down PDCD2. Our research can provide new insights into solid cancer prognostic biomarkers of PDCD2.

23 Oct 2023·Angewandte Chemie International Edition

Proteomics‐Based Discovery of First‐in‐Class Chemical Probes for Programmed Cell Death Protein 2 (PDCD2)

Article

Author: Che, Jianwei ; Fischer, Eric S. ; Gray, Nathanael S. ; Ji, Wenzhi ; Yuan, Linjie ; Zhu, Xijun ; Byun, Woong Sub ; Abulaiti, Xianmixinuer ; Zhang, Tinghu ; Donovan, Katherine A. ; Corsello, Steven M. ; Dwyer, Brendan G. ; Lu, Wenchao

AbstractChemical probes are essential tools for understanding biological systems and for credentialing potential biomedical targets. Programmed cell death 2 (PDCD2) is a member of the B‐cell lymphoma 2 (Bcl‐2) family of proteins, which are critical regulators of apoptosis. Here we report the discovery and characterization of 10 e, a first‐in‐class small molecule degrader of PDCD2. We discovered this PDCD2 degrader by serendipity using a chemical proteomics approach, in contrast to the conventional approach for making bivalent degraders starting from a known binding ligand targeting the protein of interest. Using 10 e as a pharmacological probe, we demonstrate that PDCD2 functions as a critical regulator of cell growth by modulating the progression of the cell cycle in T lymphoblasts. Our work provides a useful pharmacological probe for investigating PDCD2 function and highlights the use of chemical proteomics to discover selective small molecule degraders of unanticipated targets.

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PDCD2

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