Last update 19 Sep 2024

STARD5

Last update 19 Sep 2024

Basic Info

Synonyms

MGC10327, StAR related lipid transfer domain containing 5, StAR-related lipid transfer protein 5

+ [2]

Introduction

May be involved in the intracellular transport of sterols or other lipids. May bind cholesterol or other sterols (By similarity).

Drugs associated with STARD5

STARD5 inhibitors(Virginia Commonwealth University)

Target

STARD5

Mechanism

STARD5 inhibitors

Active Org.

Virginia Commonwealth University

Originator Org.

Virginia Commonwealth University

Active Indication

Colorectal Cancer

Inactive Indication-

Drug Highest PhasePreclinical

First Approval Ctry. / Loc.-

First Approval Date20 Jan 1800

100 Clinical Results associated with STARD5

100 Translational Medicine associated with STARD5

0 Patents (Medical) associated with STARD5

Literatures (Medical) associated with STARD5

02 Aug 2024·Journal of Asthma

Decoding the genetic landscape of allergic rhinitis: a comprehensive network analysis revealing key genes and potential therapeutic targets

Article

Author: Lin, Xiaohong ; Liao, Ruosha ; Yuan, Chile

BACKGROUNDAllergic Rhinitis (AR), an inflammatory affliction impacting the upper respiratory tract, has been registering a substantial surge in incidence across the globe.METHODSWe embarked on examination of differentially expressed genes (DEGs) and the Weighted Gene Co-Expression Network Analysis (WGCNA). With this armory of genes identified, we engaged the tools of Gene Ontology (GO) and the Kyoto Encyclopedia of Genes and Genomes (KEGG). Our study continued with the establishment of a protein-protein interaction (PPI) network and the application of LASSO regression. Finally, we leveraged a docking model to elucidate potential drug-gene interactions involving these key genes.RESULTSThrough WGCNA and different express genes screening, PPI network was performed, identifying top 20 key genes, including CD44, CD69, CD274. LASSO regression identified three independent factors, STARD5, CST1, and CHAC1, that were significantly associated with AR. A predictive model was developed with an AUC value over 0.75. Also, 105 potential therapeutic agents were discovered, including Fluorouracil, Cyclophosphamide, Doxorubicin, and Hydrocortisone, offering promising therapeutic strategies for AR.CONCLUSIONBy fuzing DEGs with key genes derived from WGCNA, this study has illuminated a comprehensive network of gene interactions involved in the pathogenesis of AR, paving the way for future biomarker and therapeutic target discovery in AR.

01 Jun 2024·American Journal of Physiology-Gastrointestinal and Liver Physiology

StarD5 levels of expression correlate with onset and progression of steatosis and liver fibrosis

Article

Author: Pandak, William M ; Kakiyama, Genta ; Bai-Kamara, Nanah ; Rodriguez-Agudo, Daniel ; Minoiwa, Kei ; Hashiguchi, Taishi

We have found that deletion of the cholesterol transport protein StarD5 in mice leads to an increase in insulin resistance and lipid accumulation due to the upregulation of lipid synthesis and decrease VLDL secretion from the liver. In addition, deletion of StarD5 increased fibrosis when mice were fed a Western diet. This represents a novel pathway of fibrosis development in the liver.

01 Oct 2023·Molecular oncology

Integrative analysis of mRNA and miRNA expression profiles and somatic variants in oxysterol signaling in early-stage luminal breast cancer.

Article

Author: Souček, Pavel ; Brynychová, Veronika ; Vrána, David ; Mrhalová, Marcela ; Gatěk, Jiří ; Kopečková, Kateřina ; Haničinec, Vojtěch ; Trnková, Markéta ; Šeborová, Karolína ; Koževnikovová, Renata ; Holý, Petr

Oxysterols, oxidized derivatives of cholesterol, act in breast cancer (BC) as selective estrogen receptor modulators and affect cholesterol homeostasis, drug transport, nuclear and cell receptors, and other signaling proteins. Using data from three highly overlapping sets of patients (N = 162 in total) with early-stage estrogen-receptor-positive luminal BC-high-coverage targeted DNA sequencing (113 genes), mRNA sequencing, and full micro-RNA (miRNA) transcriptome microarrays-we describe complex oxysterol-related interaction (correlation) networks, with validation in public datasets (n = 538) and 11 databases. The ESR1-CH25H-INSIG1-ABCA9 axis was the most prominent, interconnected through miR-125b-5p, miR-99a-5p, miR-100-5p, miR-143-3p, miR-199b-5p, miR-376a-3p, and miR-376c-3p. Mutations in SC5D, CYP46A1, and its functionally linked gene set were associated with multiple differentially expressed oxysterol-related genes. STARD5 was upregulated in patients with positive lymph node status. High expression of hsa-miR-19b-3p was weakly associated with poor survival. This is the first study of oxysterol-related genes in BC that combines DNA, mRNA, and miRNA multiomics with detailed clinical data. Future studies should provide links between intratumoral oxysterol signaling depicted here, circulating oxysterol levels, and therapy outcomes, enabling eventual clinical exploitation of present findings.

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STARD5

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